Results 61 to 70 of about 5,089,703 (351)

Lime stabilisation for earthworks: a UK perspective [PDF]

, 2014
Lime stabilisation is a versatile technique applied during earthworks operations. Modern soil recycling units are much more efficient at pulverising fill material and intermixing the added binder/water than machinery available 20 years ago.
Beetham P, Bell FG, Bergado DT, Bin S, Bohn HL, BSI, BSI, BSI, Davidson LK, Diamond S, Eades JE, Greaves HM, Highways Agency, Highways Agency, Highways Agency, Holt CC, Ingles OG, John Bateman, Longworth I, McAllister LD, Mitchell JK, Neil Dixon, Paul Beetham, Paul Fleming, Perry J, Petry TM, Reeves GM, Robert Hutchison, Rowell DL, Sherwood PT, Sherwood PT, Snedker EA, Stocker PT, Sweeney DA, Taylor HFW, Tom Dijkstra, Van Olphen H, Winter NB   +37 more
core   +2 more sources

Optimization of Cefixime Nanosuspension to Improve Drug Dissolution [PDF]

Pharmaceutical Sciences, 2015
Background: The aim of this study was to prepare and characterize cefixime nanosuspensions in order to enhance the dissolution rate and solubility of this drug. Methods: Nanosuspensions were prepared using sonoprecipitation method and the effects of surfactant type, surfactant and solid content, sonication power input and interval of acid addition
Elham Ghasemian, Behnaz Rezaeian, Samaneh Alaei, Alireza Vatanara, Vahid Ramezani   +4 more
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Synthesis, Characterization, and Intrinsic Dissolution Studies of Drug–Drug Eutectic Solid Forms of Metformin Hydrochloride and Thiazide Diuretics

Pharmaceutics, 2021
The mechanochemical synthesis of drug–drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported.
Guadalupe Coyote-Dotor, José C. Páez-Franco, Daniel Canseco-González, Alejandra Núñez-Pineda, Alejandro Dorazco-González, Inés Fuentes-Noriega, Alfredo R. Vilchis-Néstor, Joelis Rodríguez-Hernández, David Morales-Morales, Juan Manuel Germán-Acacio   +9 more
doaj   +1 more source

DEVELOPMENT OF NANOCRYSTAL FORMULATION WITH IMPROVED DISSOLUTION

Journal of Drug Delivery and Therapeutics, 2018
With the advancement in modern pharmaceutical technologies, Nanotechnology is the one of the most establish technology which is used to improve the therapeutic index and to overcome the formulation challenges of poorly water-soluble compounds. Nanocrystals, in nano range, is the interesting approach for poorly soluble drugs.
Sandeep Kumar, Jaspreet Kaur Saini
openaire   +2 more sources

Surface Stabilization and Dissolution Rate Improvement of Amorphous Compacts with Thin Polymer Coatings: Can We Have It All?

Molecular Pharmaceutics, 2020
The distinction between surface and bulk crystallization of amorphous pharmaceuticals, as well as the importance of surface crystallization for pharmaceutical performance, is becoming increasingly evident.
D. Novakovic, L. Peltonen, A. Isomäki, S. Fraser‐Miller, L. Nielsen, T. Laaksonen, C. Strachan   +6 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Polyetherimide foams filled with low content of graphene nanoplatelets prepared by scCO2 dissolution [PDF]

, 2019
Polyetherimide (PEI) foams with graphene nanoplatelets (GnP) were prepared by supercritical carbon dioxide (scCO2) dissolution. Foam precursors were prepared by melt-mixing PEI with variable amounts of ultrasonicated GnP (0.1–2.0 wt %) and foamed by one ...
Abbasi, Hooman, Antunes, Marcelo de Sousa Pais, Velasco Perero, José Ignacio   +2 more
core   +2 more sources

MCM-41 for Meloxicam Dissolution Improvement: in vitro Release and in vivo Bioavailability Studies

, 2015
In this study, MCM-41 was prepared as a carrier for poorly water soluble drugs. Meloxicam (MLX) was selected as model compound. Textural and chemical characterizations were carried out by thermal gravimetric analysis (TGA), scanning electron microscope ...
A. Hassan, S. Helmy, A. Donia
semanticscholar   +1 more source

Dissolution Improvement of Atorvastatin Calcium using Modified Locust Bean Gum by the Solid Dispersion Technique

Scientia Pharmaceutica, 2013
The present research was aimed at the enhancement of the dissolution rate of atorvastatin calcium by the solid dispersion technique using modified locust bean gum.
Dharmila Panghal, M. Nagpal, G. Thakur, S. Arora   +3 more
semanticscholar   +1 more source