Results 71 to 80 of about 5,089,703 (351)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Improvement of Solubility and Dissolution of Niclosamide using Metal Organic Framework 5 (MOF-5)

Iraqi Journal of Pharmaceutical Sciences
Metal-organic frameworks-5 (MOF-5) were explored for enhancement of the solubility and dissolution of the drug niclosamide (NIC). MOF-5 was synthesized by solvothermal method and NIC was loaded into it (NIC@MOF-5).
Hayder Yahya Mansoor Al-Jarsha, Mowafaq M. Ghareeb   +1 more
doaj   +1 more source

In vitro dissolution study of atorvastatin binary solid dispersion

Journal of Advanced Pharmaceutical Technology & Research, 2013
The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV), a slight water-soluble drug, by solid dispersion (SD) technique using a hydrophilic carrier Poloxamer 188 (POL188).
Rahat Jahan, Md. Saiful Islam, Ahmad Tanwir, Jakir Ahmed Chowdhury   +3 more
doaj   +1 more source

Formulation and In-Vitro Evaluation of Meloxicam Solid Dispersion using Natural Polymers.

Iraqi Journal of Pharmaceutical Sciences, 2021
Meloxicam (MLX) is non-steroidal anti -inflammatory, poorly water soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract.
Hiba R. Al-Hassani, Eman B. H. Al-Khedairy   +1 more
doaj   +1 more source

Highly-crystallized quaternary chalcopyrite nanocrystals via a high-temperature dissolution–reprecipitation route [PDF]

, 2011
Quaternary chalcopyrite (Cu2CoSnS4, Cu2ZnSnS4) nanocrystals displaying high crystallization and controlled morphology were synthesized via a high-temperature growth regime achieved by dissolution–reprecipitation of tailored ultrafine precursors in the ...
Balocchi, Andréa, Chane-Ching, Jean-Yves, Gillorin, Arnaud, Marie, Xavier, Zaberca, Oana   +4 more
core   +2 more sources

Preparation of luliconazole nanocrystals loaded hydrogel for improvement of dissolution and antifungal activity

Heliyon, 2019
Superficial fungal infection in immunocompromised patients can lead to many disorders and complications. Currently, new topical treatment options are critically needed to treat these fungal infections.
Manish Kumar, N. Shanthi, A. Mahato, Shashank Soni, P. Rajnikanth   +4 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rivaroxaban solid dispersions for dissolution enhancement and formulation of mouth disintegrating tablets

Journal of Applied Pharmaceutical Research
Background: Work is carried out to improve rivaroxaban's dissolution rate (DR) and develop mouth-disintegrating tablets for rapid onset of action.
Kalki Ranjan Priyadarshan, Asish Sahu, Anjan Kumar Mahapatra, K. A Chowdary, Ajit Nahak, Ruchita Kumari Patra   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs

Pharmaceutics, 2023
Calcium carbonate is an excipient traditionally used in solid dosage forms with several functions such as a diluent, a quick dissolution agent, a buffer and an opacifier.
Valeria Ambrogi
doaj   +1 more source