Results 91 to 100 of about 15,452 (227)

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome [PDF]

The American Journal of Human Genetics, 2015
Adams-Oliver syndrome (AOS) is a rare developmental disorder characterized by the presence of aplasia cutis congenita (ACC) of the scalp vertex and terminal limb-reduction defects. Cardiovascular anomalies are also frequently observed. Mutations in five genes have been identified as a cause for AOS prior to this report.
Meester, JAN, Southgate, L, Stittrich, A-B, Venselaar, H, Beekmans, SJA, den Hollander, N, Bijlsma, EK, den Enden, AH-V, Verheij, JBGM, Glusman, G, Roach, JC, Lehman, A, Patel, MS, de Vries, BBA, Ruivenkamp, C, Itin, P, Prescott, K, Clarke, S, Trembath, R, Zenker, M, Sukalo, M, Van Laer, L, Loeys, B, Wuyts, W   +23 more
openaire   +8 more sources

Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni, Paride Pelucchi, Erika Paolini, Miriam Longo, Ada Sula, Michele Battistin, Alice Chiodi, Deborah Mattinzoli, Masami Ikehata, Elena Trombetta, Daniele Dondossola, Alessandra Mezzelani, Gianluca Martino Tartaglia, Giuseppe Castellano, Anna Ludovica Fracanzani, Flora Peyvandi, Stefano Gatti, Ettore Mosca, Paola Dongiovanni   +18 more
wiley   +1 more source

Hepatitis B Virus HBx Activates Notch Signaling via Delta-Like 4/Notch1 in Hepatocellular Carcinoma. [PDF]

PLoS ONE, 2016
Hepatitis virus B (HBV) infection is one of the major causes of hepatocellular carcinomas (HCC). HBx protein encoded in HBV genome is one of the key viral factors leading to malignant transformation of infected cells.
Pornrat Kongkavitoon, Pisit Tangkijvanich, Nattiya Hirankarn, Tanapat Palaga   +3 more
doaj   +1 more source

Targeting Angiogenesis in Cancer Therapy [PDF]

, 2011
Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a ...
Ichihara, Eiki, Kiura, Katsuyuki, Tanimoto, Mitsune   +2 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

miR-124 promotes proliferation and differentiation of neuronal stem cells through inactivating Notch pathway

Cell & Bioscience, 2017
Background Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation.
Shujie Jiao, Yaling Liu, Yaobing Yao, Junfang Teng   +3 more
doaj   +1 more source

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms [PDF]

, 2018
Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue ...
Alitalo, Kari, Frye, Maike, Martinez-Corral, Ines, Mäkinen, Taija, Stanczuk, Lukas, Ulvmar, Maria H., Zhang, Yan   +6 more
core   +1 more source

Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers? [PDF]

, 2020
The signal for maternal recognition of pregnancy (MRP) has still not been identified in the horse. High-throughput molecular biology at the embryo-maternal interface has substantially contributed to the knowledge on pathways affected during MRP, but an ...
Deforce, Dieter, Gansemans, Yannick, Gerits, Ilse, Govaere, Jan, Peelman, Luc, Roels, Kim, Smits, Katrien, Tilleman, Laurentijn, Van de Velde, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Ververs, Cyrillus   +11 more
core   +2 more sources

Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4.

PLoS ONE, 2013
BackgroundEndothelial DLL4 plays an important role in controlling of tumor angiogenesis, which is required for tumor invasive growth and metastasis.
Qing Bo Huang, Xin Ma, Xu Zhang, Shang Wen Liu, Qing Ai, Tao Ping Shi, Yu Zhang, Yu Gao, Yang Fan, Dong Ni, Bao Jun Wang, Hong Zhao Li, Tao Zheng   +12 more
doaj   +1 more source