Results 91 to 100 of about 15,361 (230)

TMZ regulates GBM stemness via MMP14‐DLL4‐Notch3 pathway [PDF]

International Journal of Cancer, 2019
Glioblastoma (GBM) is one of the most aggressive primary brain tumors with frequent recurrences following the standard methods of treatment—temozolomide (TMZ), ionizing radiation and surgical resection. The objective of our study was to investigate GBM resistance mediated via MMP14 (matrix metalloproteinase 14).
Ilya V. Ulasov, Olja Mijanovic, Solomiia Savchuk, Edgar Gonzalez‐Buendia, Adam Sonabend, Ting Xiao, Petr Timashev, Maciej S. Lesniak   +7 more
openaire   +2 more sources

M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn's Disease [PDF]

, 2016
Background: The Notch signalling pathway plays an essential role in mucosal regeneration, which constitutes a key goal of Crohn's disease (CD) treatment.
Alós Company, Rafael, Barrachina Sancho, María Dolores, Calatayud Romero, Sara, Cosín Roger, Jesús, Esplugues Mota, Juan Vicente, Hernández, C., Hinojosa, Joaquin, Ortiz Masiá, María Dolores   +7 more
core   +1 more source

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

Cell Proliferation, EarlyView.
This review highlights emerging strategies to engineer vascularized brain organoids—including endothelial co‐culture, genetic induction, perfusion systems, and in vivo transplantation—and their applications in modelling neurovascular diseases, evaluating BBB drug delivery, and advancing regenerative medicine.
Yeajin Song, Hyejin Jo, Seokchan Jeong, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome [PDF]

The American Journal of Human Genetics, 2015
Adams-Oliver syndrome (AOS) is a rare developmental disorder characterized by the presence of aplasia cutis congenita (ACC) of the scalp vertex and terminal limb-reduction defects. Cardiovascular anomalies are also frequently observed. Mutations in five genes have been identified as a cause for AOS prior to this report.
Meester, JAN, Southgate, L, Stittrich, A-B, Venselaar, H, Beekmans, SJA, den Hollander, N, Bijlsma, EK, den Enden, AH-V, Verheij, JBGM, Glusman, G, Roach, JC, Lehman, A, Patel, MS, de Vries, BBA, Ruivenkamp, C, Itin, P, Prescott, K, Clarke, S, Trembath, R, Zenker, M, Sukalo, M, Van Laer, L, Loeys, B, Wuyts, W   +23 more
openaire   +8 more sources

Targeting Angiogenesis in Cancer Therapy [PDF]

, 2011
Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a ...
Ichihara, Eiki, Kiura, Katsuyuki, Tanimoto, Mitsune   +2 more
core   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Expression of DLL4 and VEGF in Lung Adenocarcinoma and their Relationship with Angiogenesis in Tumor

Chinese Journal of Lung Cancer, 2009
Background and objective Angiogenesis depends on the interaction of a variety of promoting factors and inhibiting factors. Vascular endothelial growth factor (VEGF) and Notch signaling pathway take part in this process.
Xiaoping LI, Qingfu ZHANG, Bin LU, Xueshan QIU, Yang LUO, Weidong ZHANG, Shun XU   +6 more
doaj  

miR-124 promotes proliferation and differentiation of neuronal stem cells through inactivating Notch pathway

Cell & Bioscience, 2017
Background Neural stem cells (NSCs) are able to differentiate into neurons and astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation and differentiation.
Shujie Jiao, Yaling Liu, Yaobing Yao, Junfang Teng   +3 more
doaj   +1 more source

Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle [PDF]

, 2013
Articles in International JournalsThe transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key ...
A Fischer, a Hess R, a Hess R, Alexandre Trindade, António Duarte, AR Bellvi, B Bielesz, BR Nebel, C Afonso, C Firlit, C Zeng, Daniel Murta, Domingos Henrique, E Assa-Kunik, E Silva, E Silva, EF OAKBERG, EJ Lambie, EJ Ward, Elisabete Silva, F Batista, G Dirami, H Takanaga, H-T Cheng, HB Ariyaratne, I Sörensen, J Boucher, J Kimble, J Lu, J Zavadil, Jean-Marc A. Lobaccaro, K Hasegawa, K Shimizu, KL Hahn, LT Krebs, Luís Lopes-da-Costa, M Lupien, M Morimoto, M Rahmana, M Stahl, M-C Hofmann, Marta Batista, Mruk Wong, EWP Dolores D, R Bultje, R Habert, RM Das, S Artavanis-Tsakonas, S Kimmins, S Mori, SS Saravanamuthu, T Borggrefe, T DeFalco, T Hayashi, T Hayashi, T Kitamoto, TX Garcia, V Von Schönfeldt, X Feng, X Song, Y Clermont, Y Kitadate, Y Niwa, Y Wang, Z Sahin, Z Yuan   +64 more
core   +3 more sources

Targeting the Notch receptor dimerization domain to inhibit Notch signalling—A new avenue of therapeutics

The FEBS Journal, EarlyView.
Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to genetic mutations that occur within the negative regulatory region of the Notch 1 gene is linked to the development of ...
Gerard F Hoyne
wiley   +1 more source