Results 51 to 60 of about 15,452 (227)

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development, Implications for the Treatment of Vein Graft Failure [PDF]

, 2015
Objective—Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease.
Aikawa, Masanori, Anderson, Daniel Griffith, Aster, Jon C., Dahlman, James E., Decano, Julius, Figueiredo, Jose-Luiz, Iwata, Hiroshi, Khan, Omar F., Koga, Jun-ichiro, Nakano, Toshiaki, Niida, Tomiharu, Ozaki, C. Keith, Yagita, Hideo, Zhang, Hengmin   +13 more
core   +1 more source

miR-153-3p inhibits renal cancer cell growth and angiogenesis by negatively regulating the DLL4-mediated Notch pathway

徐州医科大学学报
Objective To investigate the effects of miR-153-3p on cell proliferation and angiogenesis in renal cell carcinoma (RCC) and its underlying mechanism.Methods The expression of miR-153-3p in RCC adjacent and tumor tissues was analyzed based on the TCGA ...
WAN Xiaoxiang, XU Yaozong, ZHANG Jun, WANG Yang, SHI Guowei, WANG Xilong   +5 more
doaj   +1 more source

The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Journal of Investigative Surgery, 2020
Objective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline.
Chaoyang Qi, Yuting Lin, Dingsheng Lin
doaj   +1 more source

Association of Dll4/notch and HIF-1a -VEGF signaling in the angiogenesis of missed abortion. [PDF]

PLoS ONE, 2013
Dll4/Notch and HIF-1a-VEGF have been shown to play an important role during angiogenesis, but there are no data about their roles and association in missed abortion.
Yan Fang, Shuang Yu, Yuyan Ma, Ping Sun, Daoxin Ma, Chunyan Ji, Beihua Kong   +6 more
doaj   +1 more source

Inhibition of delta-like ligand 4 induces luteal hypervascularization followed by functional and structural luteolysis in the primate ovary [PDF]

, 2012
Using specific inhibitors established that angiogenesis in the ovarian follicle and corpus luteum is driven by vascular endothelial growth factor. Recently, it has been demonstrated that the Notch ligand, delta-like ligand 4 (Dll4) negatively regulates ...
Allan, Deborah, Fraser, Hamish M, Hastings, Julie M, Morris, Keith D, Rudge, John S, Wiegand, Stanley J   +5 more
core   +1 more source

The delta-like ligand 4-notch signaling inhibits tumor angiogenesis but promotes tumor growth in primary glioblastoma: An immunohistochemical study

Glioma, 2018
Background: Delta-like ligand 4 (DLL4) is a key Notch ligand implicated in tumor angiogenesis. However, previous studies have shown that the DLL4-Notch signaling inhibits tumor angiogenesis but promotes tumor progression in primary glioblastoma.
Yao Chen, Zhi-Xiong Lin, Jin-Tao Chen, Ming-Cheng Zheng   +3 more
doaj   +1 more source

Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. [PDF]

PLoS ONE, 2011
Neo-blood vessel growth (angiogenesis), which may involve the activation of pre-existing endothelial cells (EC) and/or the recruitment of bone marrow-derived vascular precursor cells (BM-VPC), is essential for tumor growth.
Carla Real, Leonor Remédio, Francisco Caiado, Cátia Igreja, Cristina Borges, Alexandre Trindade, Perpétua Pinto-do-Ó, Hideo Yagita, Antonio Duarte, Sérgio Dias   +9 more
doaj   +1 more source

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.: DLL4's opposing effects in choroidal neovascularization [PDF]

, 2012
International audienceInflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence
Calippe, Bertrand, Camelo, Serge, Cristofaro, Brunella, Devevre, Estelle, Duarte, Antonio, Eichmann, Anne, Guillonneau, Xavier, Houssier, Marianne, Jonet, Laurent, Klein, Christophe, Lavalette, Sophie, Leconte, Laurence, Levy, Olivier, Raoul, William, Sennlaub, Florian, Sulpice, Eric, Thuret, Gilles   +16 more
core   +4 more sources

MPDZ promotes DLL4-induced Notch signaling during angiogenesis

eLife, 2018
Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch signaling, receptors and ligands are clustered at adherens junctions. However, little is known about factors that control Notch activity by influencing the cellular localization of Notch ligands.
Fabian Tetzlaff, M Gordian Adam, Anja Feldner, Iris Moll, Amitai Menuchin, Juan Rodriguez-Vita, David Sprinzak, Andreas Fischer   +7 more
openaire   +3 more sources

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

eLife, 2020
Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority
Ken-ichi Hirano, Akiko Suganami, Yutaka Tamura, Hideo Yagita, Sonoko Habu, Motoo Kitagawa, Takehito Sato, Katsuto Hozumi   +7 more
doaj   +1 more source