Results 51 to 60 of about 15,361 (230)

Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis. [PDF]

PLoS ONE, 2011
Neo-blood vessel growth (angiogenesis), which may involve the activation of pre-existing endothelial cells (EC) and/or the recruitment of bone marrow-derived vascular precursor cells (BM-VPC), is essential for tumor growth.
Carla Real, Leonor Remédio, Francisco Caiado, Cátia Igreja, Cristina Borges, Alexandre Trindade, Perpétua Pinto-do-Ó, Hideo Yagita, Antonio Duarte, Sérgio Dias   +9 more
doaj   +1 more source

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

iScience, 2022
Summary: Spatial regulation of angiogenesis is important for the generation of functional engineered vasculature in regenerative medicine. The Notch ligands Jag1 and Dll4 show distinct expression patterns in endothelial cells and, respectively, promote ...
Laura A. Tiemeijer, Tommaso Ristori, Oscar M.J. A. Stassen, Jaakko J. Ahlberg, Jonne J.J. de Bijl, Christopher S. Chen, Katie Bentley, Carlijn V.C. Bouten, Cecilia M. Sahlgren   +8 more
doaj   +1 more source

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development, Implications for the Treatment of Vein Graft Failure [PDF]

, 2015
Objective—Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease.
Aikawa, Masanori, Anderson, Daniel Griffith, Aster, Jon C., Dahlman, James E., Decano, Julius, Figueiredo, Jose-Luiz, Iwata, Hiroshi, Khan, Omar F., Koga, Jun-ichiro, Nakano, Toshiaki, Niida, Tomiharu, Ozaki, C. Keith, Yagita, Hideo, Zhang, Hengmin   +13 more
core   +1 more source

miR-153-3p inhibits renal cancer cell growth and angiogenesis by negatively regulating the DLL4-mediated Notch pathway

徐州医科大学学报
Objective To investigate the effects of miR-153-3p on cell proliferation and angiogenesis in renal cell carcinoma (RCC) and its underlying mechanism.Methods The expression of miR-153-3p in RCC adjacent and tumor tissues was analyzed based on the TCGA ...
WAN Xiaoxiang, XU Yaozong, ZHANG Jun, WANG Yang, SHI Guowei, WANG Xilong   +5 more
doaj   +1 more source

Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

eLife, 2020
Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superiority
Ken-ichi Hirano, Akiko Suganami, Yutaka Tamura, Hideo Yagita, Sonoko Habu, Motoo Kitagawa, Takehito Sato, Katsuto Hozumi   +7 more
doaj   +1 more source

Computational Modeling to Quantify the Contributions of VEGFR1, VEGFR2, and Lateral Inhibition in Sprouting Angiogenesis [PDF]

, 2019
Sprouting angiogenesis is a necessary process in regeneration and development as well as in tumorigenesis. VEGF-A is the main pro-angiogenic chemoattractant and it can bind to the decoy receptor VEGFR1 or to VEGFR2 to induce sprouting.
Checa, Sara, Kühn, Clemens
core   +12 more sources

MPDZ promotes DLL4-induced Notch signaling during angiogenesis

eLife, 2018
Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch signaling, receptors and ligands are clustered at adherens junctions. However, little is known about factors that control Notch activity by influencing the cellular localization of Notch ligands.
Fabian Tetzlaff, M Gordian Adam, Anja Feldner, Iris Moll, Amitai Menuchin, Juan Rodriguez-Vita, David Sprinzak, Andreas Fischer   +7 more
openaire   +3 more sources

The delta-like ligand 4-notch signaling inhibits tumor angiogenesis but promotes tumor growth in primary glioblastoma: An immunohistochemical study

Glioma, 2018
Background: Delta-like ligand 4 (DLL4) is a key Notch ligand implicated in tumor angiogenesis. However, previous studies have shown that the DLL4-Notch signaling inhibits tumor angiogenesis but promotes tumor progression in primary glioblastoma.
Yao Chen, Zhi-Xiong Lin, Jin-Tao Chen, Ming-Cheng Zheng   +3 more
doaj   +1 more source

The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Journal of Investigative Surgery, 2020
Objective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline.
Chaoyang Qi, Yuting Lin, Dingsheng Lin
doaj   +1 more source

The significance of Notch ligand expression in the peripheral blood of children with hand, foot and mouth disease (HFMD) [PDF]

, 2014
BACKGROUND: Hand, foot and mouth disease (HFMD), a virus-induced infectious disease that usually affects infants and children, has an increased incidence in China in recent years.
Bai, Zhen Jiang, Huang, Jie, Kong, Xiao Xing, Li, Yi Ping, Lu, Chun Yu, Tian, Jian Mei, Wang, Jian, Wang, Jiang Huai, Xiang, Yong Jun   +8 more
core   +2 more sources