Results 61 to 70 of about 32,964 (245)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Oligoethylene Glycol Side‐Chain Engineering of Y6‐Derived Nonfullerene Acceptors for Thermally Induced Spontaneous Pseudo‐Planar Heterojunction Organic Photodetectors

Advanced Functional Materials, EarlyView.
OEG‐functionalized Y6‐derived acceptors induce thermally driven vertical phase separation, enabling pseudo‐planar heterojunction organic photodetectors. The resulting PM6:YTEG‐4F and PM6:YTEG‐4Cl organic photodetectors suppress dark current density by approximately 260‐fold and 210‐fold, respectively, while maintaining efficient photoresponse ...
Se Jeong Park, Sang Young Jeong, Yunji Eom, Yelim Kang, Yeonsu Choi, Seunghyun Rhee, Bo Ram Lee, Bong Joo Kang, Nam Joong Jeon, Jae Won Shim, Han Young Woo, Seo‐Jin Ko   +11 more
wiley   +1 more source

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

Angewandte Chemie, EarlyView.
The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch, Yitzhak Tor, Claudia Höbartner   +2 more
wiley   +2 more sources

Dynamische Entwicklung. Die DMT 1992

, 1993
Es wird berichtet ueber die Taetigkeit der DMT im Berichtsjahr auf folgenden Gebieten: Engineering, Beratung, Sachverstaendigen- und Prueftaetigkeit, Forschung und Entwicklung, Aus- und Fortbildung.
Deutsche MontanTechnologie fuer Rohstoff - Energie - Umwelt e.V. (DMT), Bochum (Germany)
core  

Scallop DMT functions as a Ca2+ transporter [PDF]

, 2005
We identified a DMT (divalent metal transporter) homologous protein that functions as a Ca2+ transporter. Scallop DMT cDNA encodes a 539-amino-acid protein with 12 putative membrane-spanning domains and has a consensus transport motif in the fourth ...
Nakao, Kenji, Yamamoto, Sayuri, Kaneko, Shuji, Hayashi, Isao, Toyohara, Haruhiko, Hosoi, Masatomi, Takagi, Masaya   +6 more
core   +1 more source

Dental Microwear Texture Analysis on Radular Teeth

Advanced Materials Interfaces, EarlyView.
3D microwear textures reveal how gastropod radular teeth respond to controlled abrasive contact. Distinct surface signatures distinguish regular abrasion from fracture‐dominated material removal, showing how mineralized coatings, fibrous cores, and substrate properties jointly shape wear and failure in a biological scraping interface.
Wencke Krings, Stanislav N. Gorb, Ellen Schulz‐Kornas   +2 more
wiley   +1 more source

Disparities in patient share and characteristics between disease-modifying therapy-treated and -untreated people with multiple sclerosis in Germany: a claims data analysis from 2017 to 2022

Frontiers in Neurology
IntroductionDespite significant advances in multiple sclerosis (MS) treatment, a substantial proportion of people with MS (pwMS) remains untreated with disease-modifying therapies (DMTs).
Ann-Sophie Stratil, Steffeni Papukchieva, Nils-Henning Neß, Inge Wolf, Antonios Bayas, Peter Flachenecker, Benjamin Friedrich   +6 more
doaj   +1 more source

Seil-Kolloquium (Sonderausgabe) DMT-Kompetenz rund um das Seil

, 1996
After a backward glance at 20 years' research on transport ropes, the future main points of work in shaft transport technique, the non-destructive testing of ropes, conveyor belts and parts of plant, as well as component testing and analysis of damage ...
DMT-Institut fuer Foerderung und Transport, Bochum (Germany). Seilpruefstelle
core  

Hamaker Constants of van der Waals Materials under Clean‐Interface Conditions

Advanced Science, EarlyView.
Clean‐interface adhesion in representative van der Waals materials is quantified by Ultra High Vacuum (UHV) Atomic Force Microscopy (AFM) with in situ cleaning and calibrated probes. Benchmark Hamaker constants for graphene, MoS2, and SiO2 are established, while humidity is shown to reversibly amplify adhesion, explaining much of the scatter in ...
Daniel Gallego‐Fuente, Jaime Colchero, Julio Gomez‐Herrero, Pablo Ares   +3 more
wiley   +1 more source

Helical Single Crystals of Porous Hydrogen‐Bonded Organic Frameworks as a Candidate for Morphologically Functional Organic Materials

Angewandte Chemie, EarlyView.
Helical‐shaped crystals of a hydrogen‐bonded organic framework (HOF) with permanent porosity have been developed. The helical HOF shows expansion and contraction, respectively, upon desorption and adsorption of solvents. Moreover, doping of additive molecules can modulate the photophysical properties and morphology of the helical HOF, showing the ...
Yuzuki Murata, Taito Hashimoto, Ryusei Oketani, Miki Naruoka, Yuuya Nagata, Ryosuke Tamura, Masayuki Morimoto, Mio Yamashita, Daisuke Sakamaki, Norimitsu Tohnai, Hitoshi Asakawa, Ichiro Hisaki   +11 more
wiley   +2 more sources