Results 1 to 10 of about 3,240,653 (337)

Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair. [PDF]

Theranostics, 2022
The efficiency of gene therapy is often dictated by the gene delivery system. Cationic polymers are essential elements of gene delivery systems. The relatively cheap cationic polymer, polyethyleneimine, has high gene delivery efficiency and is often used
Kim HJ, Cho HB, Lee S, Lyu J, Kim HR, Lee S, Park JI, Park KH.   +7 more
europepmc   +2 more sources

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Experimental and Molecular Medicine, 2023
Inflammatory diseases: Understanding mitochondrial DNA release Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeonghan Kim, Ho-Shik Kim, Jay H. Chung
doaj   +2 more sources

The Mitochondrial Response to DNA Damage

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong, Peipei Tu, Peiqi Xu, Yan Sun, Fangfang Yu, Na Tu, Lixia Guo, Yanan Yang   +7 more
doaj   +2 more sources

Mitochondrial DNA: the overlooked oncogenome? [PDF]

BMC Biology, 2019
Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected source is that of the mitochondrial ...
P. Gammage, C. Frezza
semanticscholar   +7 more sources

Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness

bioRxiv, 2023
Somatic variation contributes to biological heterogeneity by modulating cellular proclivity to differentiate, expand, adapt, or die. While large-scale sequencing efforts have revealed the foundational role of somatic variants to drive human tumor ...
Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez, R. Dhindsa, Anne-Sophie Gribling-Burrer, Yu-Hsin Hsieh, Lena Nitsch, Frank A Buquicchio, Tsion Abay, Sebastian Zielinski, Robert R. Stickels, Jacob C. Ulirsch, Patrick K. Yan, Fangyi Wang, Zhuang Miao, Katalin D. Sandor, Bence Dániel, Vincent Liu, Quanli Wang, Fengyuan Hu, Katherine R Smith, S. V. Deevi, P. Maschmeyer, S. Petrovski, R. Smyth, William J. Greenleaf, Anshul B Kundaje, Mathias Munschauer, Leif S. Ludwig, Ansuman T. Satpathy   +29 more
semanticscholar   +1 more source

Whole-Exome Sequencing Identifies a Novel POLG Frameshift Variant in an Adult Patient Presenting with Progressive External Ophthalmoplegia and Mitochondrial DNA Depletion

Case Reports in Genetics, 2021
Mitochondrial DNA (mtDNA) depletion syndromes are a group of autosomal recessive disorders associated with a spectrum of clinical diseases, which include progressive external ophthalmoplegia (PEO).
Justin Kurtz, Joseph Americo Fernandes, Mahesh Mansukhani, William C. Copeland, Ali B. Naini   +4 more
doaj   +1 more source

Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner

Frontiers in Immunology, 2023
One of the most proliferative periods for T cells occurs during their development in the thymus. Increased DNA replication can result in increased DNA mutations in the nuclear genome, but also in mitochondrial genomes.
Candice B. Limper, Narda Bondah, Daphne Zhu, Alanis N. Villanueva, Uchenna K. Chukwukere, Weishan Huang, Weishan Huang, Avery August, Avery August   +8 more
doaj   +1 more source

The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome

Biomolecules, 2023
Nuclear-mitochondrial DNA segments (NUMTs) are mitochondrial DNA (mtDNA) fragments that have been inserted into the nuclear genome. Some NUMTs are common within the human population but most NUMTs are rare and specific to individuals. NUMTs range in size
Liying Xue, Jesse D. Moreira, Karan K. Smith, Jessica L. Fetterman   +3 more
doaj   +1 more source

Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

Genome Biology, 2020
Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan, Matthew J. Longley, Margaret H. Humble, Christopher A. Lavender, Adam Burkholder, Emma L. Blakely, Charlotte L. Alston, Grainne S. Gorman, Doug M. Turnbull, Robert McFarland, Robert W. Taylor, Thomas A. Kunkel, William C. Copeland   +12 more
doaj   +1 more source

Whole Mitochondrial Genome Analysis in Turkish Patients With Mitochondrial Diseases

Balkan Medical Journal, 2022
Background: Mitochondrial diseases are a clinically heterogeneous group of rare hereditary disorders that are defined by a genetic defect predominantly affecting mitochondrial oxidative phosphorylation.
Emine Begüm Gencer Öncül, Duygu Duman, Fatma Tuba Eminoğlu, Süleyman Aktuna, Mustafa Türker Duman   +4 more
doaj   +1 more source