Results 1 to 10 of about 3,161,098 (232)
MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.
PLoS Genetics, 2016 MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic ...
Ilaria Dalla Rosa +18 more
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SYBR Gold dye enables preferential labelling of mitochondrial nucleoids and their time-lapse imaging by structured illumination microscopy. [PDF]
PLoS ONE, 2018 Mitochondrial DNA molecules coated with proteins form compact particles called mitochondrial nucleoids. They are redistributed within mitochondrial network undergoing morphological changes. The straightforward technique to characterize nucleoids' motions
Visnja Jevtic +2 more
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Mitochondrial DNA and Disease [PDF]
Annals of Medicine, 1997 Mitochondrial diseases are a group of disorders characterized by morphological or functional defects of the mitochondria, the organelles producing most of our cellular energy. As the only extranuclear site carrying genetic information, the mitochondria add an important chapter into the inheritance patterns of genetic diseases. Mitochondrial DNA (mtDNA)
openaire +2 more sources
Frontiers in AgingAging is the major risk factor in most of the leading causes of mortality worldwide, yet its fundamental causes mostly remain unclear. One of the clear hallmarks of aging is mitochondrial dysfunction.
Charlotte Sprason +2 more
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CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair
Cell Reports, 2015 Nuclear DNA repair capacity is a critical determinant of cell fate under genotoxic stress conditions. DNA repair is a well-defined energy-consuming process.
Lili Qin +8 more
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Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment
Scientific Reports, 2021 Mitochondrial diseases currently have no cure regardless of whether the cause is a nuclear or mitochondrial genome mutation. Mitochondrial dysfunction notably affects a wide range of disorders in aged individuals, including neurodegenerative diseases ...
Hideki Maeda +4 more
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The alternative reality of plant mitochondrial DNA: One ring does not rule them all
bioRxiv, 2019 Plant mitochondrial genomes are usually assembled and displayed as circular maps based on the widely-held view across the broad community of life scientists that circular genome-sized molecules are the primary form of plant mitochondrial DNA, despite the
A. Kozik +6 more
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Replicating animal mitochondrial DNA [PDF]
Genetics and Molecular Biology, 2013 The field of mitochondrial DNA (mtDNA) replication has been experiencing incredible progress in recent years, and yet little is certain about the mechanism(s) used by animal cells to replicate this plasmid-like genome. The long-standing strand-displacement model of mammalian mtDNA replication (for which single-stranded DNA intermediates are a hallmark)
McKinney, Emily A., Oliveira, Marcos T.
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Cell Death and Disease, 2023 Mitochondrial dysfunction is important in various chronic degenerative disorders, and aberrant immune responses elicited by cytoplasmic mitochondrial DNA (mtDNA) may be related.
June Heo +10 more
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Mitochondrial DNA: Distribution, Mutations, and Elimination
Cells, 2019 Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial ...
Chaojun Yan +4 more
semanticscholar +1 more source