Results 21 to 30 of about 3,128,275 (354)
Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report
Frontiers in Neurology, 2022 Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini +1 more
doaj +1 more source
Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA [PDF]
, 2017 In the absence of infection, the pathophysiology of endotracheal tube-induced sore throat pain is unclear. Activated neutrophils release elastase, reactive oxygen species, and inflammatory cytokines known to contribute to neuropathic pain. Sterile tissue
Earhart, Alexander +9 more
core +2 more sources
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death
Autophagy, 2020 Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates.
Changfeng Li +5 more
semanticscholar +1 more source
Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]
, 2004 Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H +10 more
core +2 more sources
Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]
, 2009 Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K. +2 more
core +2 more sources
Mitochondrial DNA copy number in human disease: the more the better?
FEBS Letters, 2020 Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative phosphorylation (OXPHOS). In mammals, a gene‐dense
R. Filograna +3 more
semanticscholar +1 more source
Analysis of Nuclear Mitochondrial DNA Segments of Nine Plant Species: Size, Distribution, and Insertion Loci [PDF]
Genomics & Informatics, 2016 Nuclear mitochondrial DNA segment (Numt) insertion describes a well-known phenomenon of mitochondrial DNA transfer into a eukaryotic nuclear genome. However, it has not been well understood, especially in plants. Numt insertion patterns vary from species
Young-Joon Ko, Sangsoo Kim
doaj +1 more source
Brain Pathology, 1992 In the past few years several syndromes have been associated with lesions of the human mitochondrial DNA. MtDNA is a small, circular extra‐nuclear chromosome encoding essential components of the respiratory chain. MtDNA‐related syndromes can be divided into two groups: mitochondrial encephalomyopathies, characterized by the presence of ragged‐red ...
Zeviani M., Antozzi C.
openaire +3 more sources
BioMed Research International, 2014 Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and ...
P. Garagnani +15 more
semanticscholar +1 more source
Spermatozoon and mitochondrial DNA [PDF]
Reproductive Medicine and Biology, 2002 In eukaryotic cells, mitochondria are the major site of ATP production, which is achieved through the electron‐transport chain and oxidative phosphorylation, according to the energy demand. Mitochondria contain their own genome (mitochondrial DNA, mtDNA) on which a limited number of genes are encoded. In the human sperm, mitochondria helically wrap the
Shuji Hirata +3 more
openaire +3 more sources