Results 21 to 30 of about 3,314,237 (327)

Mitochondrial DNA in inflammation and immunity

EMBO Reports, 2020
Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation.
Joel S. Riley, S. Tait
semanticscholar   +1 more source

Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report

Frontiers in Neurology, 2022
Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini, Paloma Gonzalez-Perez   +1 more
doaj   +1 more source

Mitochondrial DNA copy number in human disease: the more the better?

FEBS Letters, 2020
Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative phosphorylation (OXPHOS). In mammals, a gene‐dense
R. Filograna, M. Mennuni, David Alsina, N. Larsson   +3 more
semanticscholar   +1 more source

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]

, 2018
BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin, Burelle, Yan, Coccia, Michael, Cuillerier, Alexanne, Epel, Elissa S, Picard, Martin, Prather, Aric A, Puterman, Eli   +7 more
core   +1 more source

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Autophagy, 2020
Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates.
Changfeng Li, Ying Zhang, Jiao Liu, R. Kang, D. Klionsky, D. Tang   +5 more
semanticscholar   +1 more source

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

BioMed Research International, 2014
Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and ...
P. Garagnani, C. Pirazzini, C. Giuliani, M. Candela, P. Brigidi, F. Sevini, D. Luiselli, M. Bacalini, S. Salvioli, M. Capri, D. Monti, D. Mari, S. Collino, M. Delledonne, P. Descombes, C. Franceschi   +15 more
semanticscholar   +1 more source

Analysis of Nuclear Mitochondrial DNA Segments of Nine Plant Species: Size, Distribution, and Insertion Loci [PDF]

Genomics & Informatics, 2016
Nuclear mitochondrial DNA segment (Numt) insertion describes a well-known phenomenon of mitochondrial DNA transfer into a eukaryotic nuclear genome. However, it has not been well understood, especially in plants. Numt insertion patterns vary from species
Young-Joon Ko, Sangsoo Kim
doaj   +1 more source

DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging

Journal of Aging Research, 2011
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
doaj   +1 more source

DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction

Journal of Advanced Research, 2022
Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou, Jun Tao, Junxiong Qiu, Huimin Lu, Jianhua Wu, Hang Zhu, Ruibing Li, David Mui, Sam Toan, Xing Chang, Hao Zhou, Xiaoping Fan   +11 more
doaj   +1 more source

Mitochondrial DNA sequencing of a wet-collection syntype demonstrates the importance of type material as genetic resource for lantern shark taxonomy (Chondrichthyes: Etmopteridae)

Royal Society Open Science, 2021
After initial detection of target archival DNA of a 116-year-old syntype specimen of the smooth lantern shark, Etmopterus pusillus, in a single-stranded DNA library, we shotgun-sequenced additional 9 million reads from this same DNA library.
Nicolas Straube, Michaela Preick, Gavin J. P. Naylor, Michael Hofreiter   +3 more
doaj   +1 more source