Results 51 to 60 of about 3,128,275 (354)
G-Quadruplex Dynamics Contribute To Regulation Of Mitochondrial Gene Expression [PDF]
, 2019 Single-stranded DNA or RNA sequences rich in guanine (G) can adopt non-canonical structures known as G-quadruplexes (G4). Mitochondrial DNA (mtDNA) sequences that are predicted to form G4 are enriched on the heavy-strand and have been associated with ...
Alder, J. K. +18 more
core +3 more sources
Complete mitochondrial genomes of two marine monogonont rotifer Brachionus manjavacas strains
Mitochondrial DNA. Part B. Resources, 2021 The complete mitochondrial genomes of Brachionus manjavacas German strain were 10,721 bp (mitochondrial DNA I) and 12,274 bp (mitochondrial DNA II) in size, while the complete mitochondrial genomes of B.
Min-Sub Kim +7 more
doaj +1 more source
Modeling Mito-nuclear Compatibility and its Role in Species Identification [PDF]
Systematic Biology 70(1) pp.133-144, 2021, 2020 Mitochondrial genetic material is widely used for phylogenetic reconstruction and as a barcode for species identification. Here we study how mito-nuclear interactions affect the accuracy of species identification by mtDNA, as well as the speciation process itself.
arxiv +1 more source
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing.
openaire +3 more sources
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. [PDF]
, 2007 The mechanism of mitochondrial DNA replication is a subject of intense debate. One model proposes a strand-asynchronous replication in which both strands of the circular genome are replicated semi-independently while the other model proposes both a ...
Goffart, S +4 more
core +1 more source
BMC Psychiatry, 2023 Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease.
Jiewen Huang +6 more
doaj +1 more source
Frontiers in Bioscience, 2017 Plants possess mitochondrial genomes that are large and complex compared to animals. Nearly all animal mitochondrial genomes are about 16.5. kbp in length, whereas plant mitochondrial genomes range between 200-2,000 kbp. This is curious if we assume modern mitochondria originated from a common alpha-proteobacterial ancestor.
Stewart A. Morley, Brent L. Nielsen
openaire +3 more sources
Mitochondrial DNA in Sepsis [PDF]
Current Opinion in Critical Care, 2017 Purpose of review Our understanding of critical illness is transforming as we develop a better understanding of the impact pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) have on the pathogenesis of disease. Of the known DAMPs, there is a growing interest in mitochondrial DNA (mtDNA) as a
Kiichi Nakahira +2 more
openaire +3 more sources
Archaic mitochondrial DNA inserts in modern day nuclear genomes
, 2019 Traces of interbreeding of Neanderthals and Denisovans with modern humans in the form of archaic DNA have been detected in the genomes of present-day human populations outside sub-Saharan Africa.
Bücking, R. +5 more
core +1 more source