Results 51 to 60 of about 827,580 (290)

In Vitro Analysis of the Thyroid Hormone Receptor in Mitochondrial Transcription [PDF]

, 2017
The central dogma theory relates how DNA is transcribed into messenger RNA (mRNAs) and then translated into proteins. Since the nucleus contains the majority of the DNA in cells, research related to transcription and translation focuses on these ...
Bestwick, Megan, Bruce, Kelsey, LeGrady, Dylan, Martinez, Adan A.   +3 more
core   +1 more source

Ribonucleotides in mitochondrial DNA [PDF]

FEBS Letters, 2019
The incorporation of ribonucleotides (rNMPs) into DNA during genome replication has gained substantial attention in recent years and has been shown to be a significant source of genomic instability. Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with regard to their rNMP ...
Wanrooij, Paulina H., Chabes, Andrei
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Inhibition of mTOR prevents ROS production initiated by ethidium bromide-induced mitochondrial DNA depletion.

Frontiers in Endocrinology, 2014
The regulation of mitochondrial mass and DNA content involves a complex interaction between mitochondrial DNA replication machinery, functional components of the electron transport chain, selective clearance of mitochondria, and nuclear gene expression ...
Timothy eNacarelli, Ashley eAzar, Christian eSell   +2 more
doaj   +1 more source

Immunological evaluation of patients with Alzheimer's disease based on mitogen-stimulated cytokine productions and mitochondrial DNA indicators

BMC Psychiatry, 2023
Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease.
Jiewen Huang, Zhen Song, Beiwen Wei, Qingtian Li, Ping Lin, Hui Li, Ke Dong   +6 more
doaj   +1 more source

MitoNeoD:a mitochondria-targeted superoxide probe [PDF]

, 2017
Mitochondrial superoxide (O2⋅−) underlies much oxidative damage and redox signaling. Fluorescent probes can detect O2⋅−, but are of limited applicability in vivo, while in cells their usefulness is constrained by side reactions and DNA intercalation.
Anderson, Robert F., Arndt, Sabine, Bright, Thomas P., Cairns, Andrew G., Caldwell, Stuart T., Cobley, James N., Hall, Andrew R., Hartley, Richard C., James, Andrew M., Krieg, Thomas, Logan, Angela, Mulvey, John F., Murphy, Michael P., Pell, Victoria R., Prag, Hiran A., Prime, Tracy A., Senn, Hans M., Shchepinova, Maria M., Vidoni, Sara, Yadav, Pooja   +19 more
core   +4 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

SYBR Gold dye enables preferential labelling of mitochondrial nucleoids and their time-lapse imaging by structured illumination microscopy. [PDF]

PLoS ONE, 2018
Mitochondrial DNA molecules coated with proteins form compact particles called mitochondrial nucleoids. They are redistributed within mitochondrial network undergoing morphological changes. The straightforward technique to characterize nucleoids' motions
Visnja Jevtic, Petra Kindle, Sergiy V Avilov   +2 more
doaj   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Craig, Elisabeth A., Herrmann, Johannes M., Neupert, Walter, Stuart, Rosemary A.   +3 more
core   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source