Results 1 to 10 of about 496,846 (295)

TUBA1A-GLI1 fusion in a soft tissue myoepithelial neoplasm

Human Pathology: Case Reports, 2021
Several types of benign and malignant neoplasms harboring GLI1 gene fusions with various partner genes, including ACTB, MALAT1 and PTCH1, have been described.
Yajuan J. Liu, Michael J. Wagner, Edward Y. Kim, Eleanor Y. Chen   +3 more
doaj   +1 more source

Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease

Diagnostics, 2022
Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal ...
Gregor Hoermann
doaj   +1 more source

HYPERMETHYLATION OF DNA REPAIR GENES IS LINKED TO PROGNOSIS OF MYELODYSPLASTIC NEOPLASM

Hematology, Transfusion and Cell Therapy, 2023
Introduction: Myelodysplastic Neoplasm (MDS) is an age-associated neoplasia characterized by frequent epigenetic abnormalities. Hypermethylation of gene promoter sites is common in MDS and increases in advanced stages of the disease, which may be related
MA Viana, RTG Oliveira, MB Costa, CS Monte, DP Borges, RFP Filho, FJAB Ribeiro, HLR Junior, SMM Magalhães, RF Pinheiro   +9 more
doaj   +1 more source

DNA Copy Number Losses in Human Neoplasms [PDF]

The American Journal of Pathology, 1999
This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.
S, Knuutila, Y, Aalto, K, Autio, A M, Björkqvist, W, El-Rifai, S, Hemmer, T, Huhta, E, Kettunen, S, Kiuru-Kuhlefelt, M L, Larramendy, T, Lushnikova, O, Monni, H, Pere, J, Tapper, M, Tarkkanen, A, Varis, V M, Wasenius, M, Wolf, Y, Zhu   +18 more
openaire   +2 more sources

Diagnosis of lung squamous cell carcinoma based on metagenomic Next-Generation Sequencing

BMC Pulmonary Medicine, 2022
Background The clinical treatment of patients suspected of pulmonary infections often rely on empirical antibiotics. However, preliminary diagnoses were based on clinical manifestations and conventional microbiological tests, which could later be proved ...
Ping Wei, Yang Gao, Jing Zhang, Jianlong Lin, Huibin Liu, Keqiang Chen, Weikai Lin, Xiaojia Wang, Chune Wang, Chao Liu   +9 more
doaj   +1 more source

Systematic Investigation of DNA Methylation Associated With Platinum Chemotherapy Resistance Across 13 Cancer Types

Frontiers in Pharmacology, 2021
Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic
Ruizheng Sun, Ruizheng Sun, Chao Du, Chao Du, Jiaxin Li, Jiaxin Li, Yanhong Zhou, Yanhong Zhou, Wei Xiong, Wei Xiong, Juanjuan Xiang, Juanjuan Xiang, Jiheng Liu, Zhigang Xiao, Li Fang, Zheng Li, Zheng Li   +16 more
doaj   +1 more source

DNA repair and damage pathways in mesothelioma development and therapy

Cancer Cell International, 2022
Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis.
Faezeh Malakoti, Niloufar Targhazeh, Erfan Abadifard, Reza Zarezadeh, Sahar Samemaleki, Zatollah Asemi, Simin Younesi, Reza Mohammadnejad, Seyed Hadi Hossini, Ansar Karimian, Forough Alemi, Bahman Yousefi   +11 more
doaj   +1 more source

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation

BMC Cancer, 2023
SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across ...
Hira Javaid, Alessandro Barberis, Olga Chervova, Isar Nassiri, Vitaly Voloshin, Yusuke Sato, Seishi Ogawa, Benjamin Fairfax, Francesca Buffa, Timothy C. Humphrey   +9 more
doaj   +1 more source

DNA copy number amplification profiling of human neoplasms [PDF]

Oncogene, 2006
DNA copy number amplifications activate oncogenes and are hallmarks of nearly all advanced tumors. Amplified genes represent attractive targets for therapy, diagnostics and prognostics. To investigate DNA amplifications in different neoplasms, we performed a bibliomics survey using 838 published chromosomal comparative genomic hybridization studies and
S, Myllykangas, J, Himberg, T, Böhling, B, Nagy, J, Hollmén, S, Knuutila   +5 more
openaire   +2 more sources

SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM

Hematology, Transfusion and Cell Therapy, 2023
Introduction: Myelodysplastic Neoplasm (MDS) is characterized by cytogenetic alterations in 40-60% of cases and 94% have at least one oncogenic mutation.
RTG Oliveira, ME Escócia, LR Sampaio, DP Borges, JVC Goes, MA Viana, RDB Dias, NFAM Mendonça, SMM Magalhães, RF Pinheiro   +9 more
doaj   +1 more source