Results 1 to 10 of about 2,773,935 (245)

Genomic analysis of pancreatic juice DNA assesses malignant risk of intraductal papillary mucinous neoplasm of pancreas

Cancer Medicine, 2019
Intraductal papillary mucinous neoplasm (IPMN) of pancreas has a high risk to develop into invasive cancer or co‐occur with malignant lesion. Therefore, it is important to assess its malignant risk by less‐invasive approach.
Raúl N. Mateos, Hidewaki Nakagawa, Seiko Hirono, Shinichi Takano, Mitsuharu Fukasawa, Akio Yanagisawa, Satoru Yasukawa, Kazuhiro Maejima, Aya Oku‐Sasaki, Kaoru Nakano, Munmee Dutta, Hiroko Tanaka, Satoru Miyano, Nobuyuki Enomoto, Hiroki Yamaue, Kenta Nakai, Masashi Fujita   +16 more
doaj   +2 more sources

Comparison of performance of two Stool DNA Tests and a Faecal Immunochemical Test in Detecting Colorectal Neoplasm: a Multicentre Diagnostic Study.

Cancer Epidemiology, Biomarkers and Prevention, 2021
BACKGROUND The most widely used non-invasive screening tests for colorectal cancer (CRC) are faecal occult blood tests. Stool DNA test was developed in recent years. However, direct comparative analyses of these tests within the same population are still
P. Jin, P. You, Jingyuan Fang, Q. Kang, Fang Gu, Yunlong Cai, Huihong Zhai, Bangmao Wang, Yanqing Li, Junfeng Xu, Jiheng Wang, Yuqi He, Yang Wang, M. Dai, J. Sheng   +14 more
semanticscholar   +1 more source

TUBA1A-GLI1 fusion in a soft tissue myoepithelial neoplasm

Human Pathology: Case Reports, 2021
Several types of benign and malignant neoplasms harboring GLI1 gene fusions with various partner genes, including ACTB, MALAT1 and PTCH1, have been described.
Yajuan J. Liu, Michael J. Wagner, Edward Y. Kim, Eleanor Y. Chen   +3 more
doaj   +1 more source

Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease

Diagnostics, 2022
Liquid profiling uses circulating tumor DNA (ctDNA) for minimal invasive tumor mutational profiling from peripheral blood. The presence of somatic mutations in peripheral blood cells without further evidence of a hematologic neoplasm defines clonal ...
Gregor Hoermann
doaj   +1 more source

Cell-free DNA analysis in current cancer clinical trials: a review

British Journal of Cancer, 2022
Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment selection and clinical follow-up of cancer patients. Although its general methodological feasibility and usefulness has been demonstrated, several issues related to
M. Cisneros-Villanueva, L. Hidalgo-Pérez, M. Ríos-Romero, A. Cedro-Tanda, C. A. Ruiz-Villavicencio, K. Page, R. Hastings, D. Fernandez-Garcia, R. Allsopp, M. A. Fonseca-Montaño, S. Jiménez-Morales, V. Padilla-Palma, J. Shaw, A. Hidalgo-Miranda   +13 more
semanticscholar   +1 more source

HYPERMETHYLATION OF DNA REPAIR GENES IS LINKED TO PROGNOSIS OF MYELODYSPLASTIC NEOPLASM

Hematology, Transfusion and Cell Therapy, 2023
Introduction: Myelodysplastic Neoplasm (MDS) is an age-associated neoplasia characterized by frequent epigenetic abnormalities. Hypermethylation of gene promoter sites is common in MDS and increases in advanced stages of the disease, which may be related
MA Viana, RTG Oliveira, MB Costa, CS Monte, DP Borges, RFP Filho, FJAB Ribeiro, HLR Junior, SMM Magalhães, RF Pinheiro   +9 more
doaj   +1 more source

A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure

Leukemia, 2022
Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment ...
M. Kutyna, C. Kok, Y. Lim, Elizabeth Ngoc Hoa Tran, David Campbell, S. Paton, C. Thompson-Peach, Kelly Lim, Dimitrios Cakouros, A. Arthur, T. Hughes, Sharad Kumar, D. Thomas, S. Gronthos, D. Hiwase   +14 more
semanticscholar   +1 more source

Diagnosis of lung squamous cell carcinoma based on metagenomic Next-Generation Sequencing

BMC Pulmonary Medicine, 2022
Background The clinical treatment of patients suspected of pulmonary infections often rely on empirical antibiotics. However, preliminary diagnoses were based on clinical manifestations and conventional microbiological tests, which could later be proved ...
Ping Wei, Yang Gao, Jing Zhang, Jianlong Lin, Huibin Liu, Keqiang Chen, Weikai Lin, Xiaojia Wang, Chune Wang, Chao Liu   +9 more
doaj   +1 more source

Fecal microbial DNA markers serve for screening colorectal neoplasm in asymptomatic subjects

Journal of Gastroenterology and Hepatology, 2020
We have previously shown that fecal microbial markers might be useful for non‐invasive diagnosis of colorectal cancer (CRC) and adenoma. Here, we assessed the application of microbial DNA markers, as compared with and in combination with fecal ...
J. Q. Liang, S. Wong, C. Szeto, E. Chu, Harry C Lau, Yingxuan Chen, Jingyuan Fang, Jun Yu, J. Sung   +8 more
semanticscholar   +1 more source

Detection of Leptomeningeal Disease Using Cell-Free DNA From Cerebrospinal Fluid

JAMA Network Open, 2021
Key Points Question Can cell-free DNA analysis of cerebrospinal fluid provide additional diagnostic utility beyond cytologic assessment? Findings In this diagnostic study of 43 cerebrospinal fluid samples from 22 patients with leptomeningeal disease ...
Michael D. White, Robert H. Klein, Brian L. Shaw, Albert E Kim, Megha Subramanian, J. Mora, A. Giobbie-Hurder, Deepika Nagabhushan, Aarushi Jain, Mohini Singh, Benjamin M Kuter, Naema Nayyar, Mia S Bertalan, Jackson H Stocking, Samuel C. Markson, Matthew Lastrapes, Christopher A. Alvarez-Breckenridge, D. Cahill, G. Gydush, J. Rhoades, D. Rotem, V. Adalsteinsson, M. Mahar, Alexander Kaplan, K. Oh, R. Sullivan, E. Gerstner, S. Carter, P. Brastianos   +28 more
semanticscholar   +1 more source