Results 11 to 20 of about 2,773,935 (245)
Frontiers in Pharmacology, 2021 Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic
Ruizheng Sun +16 more
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Cancers, 2021 Simple Summary Mutation and protein-level profiling has expanded our understanding of the pathogenesis of blastic plasmacytoid dendritic cell neoplasm (BPDCN) and offered insights into potential therapeutic vulnerabilities. However, the prognostic impact
C. Yin +11 more
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DNA repair and damage pathways in mesothelioma development and therapy
Cancer Cell International, 2022 Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis.
Faezeh Malakoti +11 more
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A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation
BMC Cancer, 2023 SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across ...
Hira Javaid +9 more
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Clinical experience of immune checkpoint inhibitor for a metastatic jejunal cancer patient with a high tumor mutational burden and low expression of programmed death-ligand 1 [PDF]
Korean Journal of Clinical Oncology, 2020 Recent data showed that DNA mismatch repair deficiency can be a predictive biomarker for a favorable response of immune checkpoint inhibitors regardless of tumor type due to give rise to high tumor mutational burden (TMB) and microsatellite instability ...
Seo Ree Kim +6 more
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Aggressive NK-cell leukemia: A rare entity with diagnostic and therapeutic challenge
Human Pathology: Case Reports, 2016 Aggressive natural killer cell leukemia (ANKL) is a rare neoplasm of mature natural killer cells, with an extremely poor overall survival, which is almost always EBV related, with majority of cases reported in East Asia.
Alia Nazarullah +4 more
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Hematology, Transfusion and Cell Therapy, 2023 Introduction: Myelodysplastic Neoplasm (MDS) is characterized by cytogenetic alterations in 40-60% of cases and 94% have at least one oncogenic mutation.
RTG Oliveira +9 more
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Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia. [PDF]
PLoS ONE, 2015 Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is an intractable pediatric myeloid neoplasm. Epigenetic regulation of transcription, particularly by CpG methylation, plays an important role in tumor ...
Hirotoshi Sakaguchi +18 more
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Mediterranean Journal of Hematology and Infectious Diseases, 2017 Therapy-related leukemia or therapy-related myeloid neoplasm are widely-used terms to designate leukemia developing in persons who previously received anti-cancer therapy (for example, see references 1, 2), especially if the prior anti-cancer therapy ...
Robert Gale +2 more
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BMC Cancer, 2021 Background Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported.
Cheng Chen +8 more
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