Results 11 to 20 of about 151,067 (292)
HYPERMETHYLATION OF DNA REPAIR GENES IS LINKED TO PROGNOSIS OF MYELODYSPLASTIC NEOPLASM
Hematology, Transfusion and Cell Therapy, 2023 Introduction: Myelodysplastic Neoplasm (MDS) is an age-associated neoplasia characterized by frequent epigenetic abnormalities. Hypermethylation of gene promoter sites is common in MDS and increases in advanced stages of the disease, which may be related
MA Viana +9 more
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Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms [PDF]
Genome Research, 2021 Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA methylation. Examining the global mechanism of action of HC in the context of myeloproliferative neoplasms (MPNs), for ...
Stephania Contreras Castillo +9 more
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DNA Copy Number Losses in Human Neoplasms [PDF]
The American Journal of Pathology, 1999 This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.
Maija Wolf +18 more
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DNA copy number amplification profiling of human neoplasms [PDF]
Oncogene, 2006 DNA copy number amplifications activate oncogenes and are hallmarks of nearly all advanced tumors. Amplified genes represent attractive targets for therapy, diagnostics and prognostics. To investigate DNA amplifications in different neoplasms, we performed a bibliomics survey using 838 published chromosomal comparative genomic hybridization studies and
Jaakko Hollmén +5 more
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Molecular Identification of Human Papillomavirus DNA in Thyroid Neoplasms: Association or Serendipity? [PDF]
Cureus, 2021 Human papillomavirus (HPV) is recognized as the most important cofactor in the etiology of cancers of the cervix, esophagus, larynx, and nasopharynx. Experimental evidence suggests that HPV could have an oncogenic influence on thyroid follicular cells; however, to the best of our knowledge, there is no record of its role in human thyroid gland ...
Alfonso E. Bencomo-Alvarez +9 more
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BMC Cancer, 2021 Background Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported.
Cheng Chen +8 more
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DNA methylation and carcinogenesis in digestive neoplasms
World Journal of Gastroenterology, 1998 . Newly replicated DNA lacks thismethylation in the nascent strand. Shortly after thepassage of the replication fork, a maintenanceDNA-MTase methylates CpG dinucleotides on thenewly synthesized strand, thereby recreating thespectrum of methyl groups that existed prior toreplication.
Zheng Zhang +3 more
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Mediterranean Journal of Hematology and Infectious Diseases, 2017 Therapy-related leukemia or therapy-related myeloid neoplasm are widely-used terms to designate leukemia developing in persons who previously received anti-cancer therapy (for example, see references 1, 2), especially if the prior anti-cancer therapy ...
Robert Gale +2 more
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Frontiers in Bioengineering and Biotechnology, 2021 Here we show that surface-enhanced Raman scattering (SERS) analysis captures the relative hypomethylation of DNA from patients with acute leukemia associated with Down syndrome (AL-DS) compared with patients diagnosed with transient leukemia associated ...
Vlad Moisoiu +24 more
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Medical treatment of early stage and rare histological variants of epithelial ovarian cancer [PDF]
, 2015 Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours ...
Biglia, Nicoletta +6 more
core +3 more sources