DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters? [PDF]
Cancers, 2019 Gene regulation through DNA methylation is a well described phenomenon that has a prominent role in physiological and pathological cell-states. This epigenetic modification is usually grouped in regions denominated CpG islands, which frequently co-localize with gene promoters, silencing the transcription of those genes.
Raquel Ordoñez +3 more
openaire +3 more sources
Dependence of DNA-Histograms on The Sampling Techniques in Fine Needle Aspirates of the Breast
Analytical Cellular Pathology, 2002 48 fine needle aspiration biopsy (FNAB) samples from 25 breast cancer cases, originally used for cytodiagnosis were subjected to DNA cytometry. There were air dried smears stained with the MGG method, and samples stained with HE or PAP stain after 50 ...
A. Elzagheid, Y. Collan
doaj +1 more source
BMC Cancer, 2018 Background The Epstein-Barr virus (EBV) is closely associated with several types of malignancies. EBV is normally present in the latent state in the peripheral blood B cell compartment.
Pengfei Cao +11 more
doaj +1 more source
SINONASAL VERRUCOUS CARCINOMA Case series and review of literature [PDF]
, 2012 Verrucous carcinoma is a low grade malignancy and is a variant of squamous cell carcinoma. It is a rare tumour of the Sino nasal tract. The neoplasm occurs in older people usually in the seventh or eighth decade of life.
Iqbal, Irfan +3 more
core +3 more sources
Atypical fibroxanthoma: An unusual skin neoplasm in xeroderma pigmentosum
Indian Journal of Dermatology, 2012 Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder related to defective deoxyribonucleic acid (DNA) repair. Various cutaneous manifestations related to ultraviolet (UV) damage characterize the clinical course.
Ranjana Bandyopadhyay +3 more
doaj +1 more source
A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia [PDF]
, 2016 We report the findings from a patient who presented with a concurrent mediastinal germ cell tumor (GCT) and acute myeloid leukemia (AML). Bone marrow pathology was consistent with a diagnosis of acute megakaryoblastic leukemia (AML M7), and biopsy of an ...
Demeter, Ryan T +12 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Co-occurrence and mutual exclusivity (COME) of DNA methylation refer to two or more genes that tend to be positively or negatively correlated in DNA methylation among different samples.
Wubin Ding +6 more
doaj +1 more source
Intrahepatic cholangiocarcinoma: review and update [PDF]
, 2018 Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that could develop at any level from the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar and distal on the basis of its anatomical location.
Alvaro, Domenico +7 more
core +1 more source
Association between DNA methylation profile and malignancy in follicular-patterned thyroid neoplasms [PDF]
Endocrine-Related Cancer, 2019 Molecular differentiation between benign (follicular thyroid adenoma (FTA)) and malignant (follicular thyroid carcinoma (FTC)) thyroid neoplasms is challenging. Here, we explored the genome-wide DNA methylation profile of FTA (n.10) and FTC (n.11) compared to normal thyroid (NT) (n.7) tissues.
Affinito, Ornella +11 more
openaire +5 more sources
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: integrated analysis of data from Study 10 and ARIEL2 [PDF]
, 2017 Objective: An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC). Methods: Eligible
Bell-McGuinn, Katherine +24 more
core +1 more source