Results 41 to 50 of about 158,012 (291)

Mechanism of T-Cell Lymphomagenesis: Transformation of Growth-Factor-Dependent T-Lymphoblastoma Cells to Growth-Factor-Independent T-Lymphoma Cells [PDF]

, 1984
In a previous paper we described the induction by x-irradiation or radiation-induced leukemia virus-in-oculation of two classes of lymphoid T-cell neoplasms: The first class, designated T-cell lymphoblastoma (TCLB), consists of growth-factor-dependent ...
Altman, Amnon, Bogart, Mark H., Haas, Martin, Jones, O. W., Rothenberg, Ellen   +4 more
core   +1 more source

Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: integrated analysis of data from Study 10 and ARIEL2 [PDF]

, 2017
Objective: An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC). Methods: Eligible
Bell-McGuinn, Katherine, Brenton, James D., Castro, Cesar M., Chen, Lee-may, Coleman, Robert L., Giordano, Heidi, Goble, Sandra, Konecny, Gottfried E., Kristeleit, Rebecca S., Leary, Alexandra, Lin, Kevin K., Ma, Ling, Maloney, Lara, Mcneish, Iain A., Oaknin, Ana, Oza, Amit M., O’Malley, David M., Provencher, Diane, Raponi, Mitch, Ray-Coquard, Isabelle, Rolfe, Lindsey, Shapira-Frommer, Ronnie, Sun, James, Swisher, Elizabeth M., Tinker, Anna V.   +24 more
core   +1 more source

SINONASAL VERRUCOUS CARCINOMA Case series and review of literature [PDF]

, 2012
Verrucous carcinoma is a low grade malignancy and is a variant of squamous cell carcinoma. It is a rare tumour of the Sino nasal tract. The neoplasm occurs in older people usually in the seventh or eighth decade of life.
Iqbal, Irfan, K, SHEETAL, Mirza, Aneesa A, QAZI, SAJAD   +3 more
core   +3 more sources

Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms

Frontiers in Oncology, 2020
The purpose of the present study was to investigate whether former childhood cancer patients who developed a subsequent secondary primary neoplasm (SPN) are characterized by elevated spontaneous chromosomal instability or cellular and chromosomal ...
Sebastian Zahnreich, Alicia Poplawski, Carola Hartel, Lukas Stefan Eckhard, Danuta Galetzka, Thomas Hankeln, Markus Löbrich, Manuela Marron, Johanna Mirsch, Sylvia Ritter, Peter Scholz-Kreisel, Claudia Spix, Heinz Schmidberger   +12 more
doaj   +1 more source

DACH1 suppresses breast cancer as a negative regulator of CD44. [PDF]

, 2017
Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack ...
Kuang, Dong, Pestell, Richard, Wu, Kongming, Xiong, Jing, Xu, Hanxiao, Yu, Shengnan, Yuan, Xun   +6 more
core   +2 more sources

Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

Clinical Epigenetics, 2022
AbstractEpigenetic abnormalities in DNA hydroxymethylation (5hmC) have been detected in patients with myeloid neoplasms, suggesting that 5hmC might act as a valuable epigenetic mark to reflect the disease status of myeloid neoplasms. Here, we report systematic genome-wide mapping of the DNA hydroxymethylomes in over 70 patients with myeloid neoplasms ...
Li, Jia, Hong, Tingting, Wei, Yue, Guo, Lei, Lee, Minjung, Yang, Hui, Class, Caleb, Yang, Yaling, Wang, Xiaoqiong, He, Hua, Siwko, Stefan, You, M. James, Zhou, Yubin, Garcia-Manero, Guillermo, Huang, Yun   +14 more
openaire   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Evaluation of Methylation Status in the 5'UTR Promoter Region of the DBC2 Gene as a Biomarker in Sporadic Breast Cancer [PDF]

Cell Journal, 2012
Objective: Breast cancer is one of the most common malignancies in women worldwide. It is caused by a number of genetic and epigenetic factors. Aberrant hypermethylation of the promoter regions in specific genes is a key event in the formation and ...
Ali Bidmeshki-Pour, Mousa Keyhanee, Yousef Shafeghati, Hamid Karbassian, Mehrdad Noruzinia, Mehri Hajikhan Mirzaei   +5 more
doaj  

Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease

Current Issues in Molecular Biology, 2022
Breast cancer is the leading cause of cancer death among women worldwide. Multiple extrinsic and intrinsic factors are associated with this disease’s development.
Erika Maldonado-Rodríguez, Marisa Hernández-Barrales, Adrián Reyes-López, Susana Godina-González, Perla I. Gallegos-Flores, Edgar L. Esparza-Ibarra, Irma E. González-Curiel, Jesús Aguayo-Rojas, Adrián López-Saucedo, Gretel Mendoza-Almanza, Jorge L. Ayala-Luján   +10 more
doaj   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +2 more sources