Results 61 to 70 of about 2,773,935 (245)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Population-based screening for colorectal cancer in Wuhan, China

Frontiers in Oncology
Fecal DNA test has emerged as a non-invasive alternative for colorectal cancer (CRC) screening in average-risk population. However, there is currently insufficient evidence in China to demonstrate the effectiveness of population-based CRC screening using
Song Liu, Song Liu, Yifan Wang, Yifan Wang, Yuying Wang, Chaofan Duan, Chaofan Duan, Fan Liu, Fan Liu, Heng Zhang, Xia Tian, Xiangwu Ding, Manling Zhang, Manling Zhang, Dan Cao, Dan Cao, Yi Liu, Yi Liu, Ruijingfang Jiang, Duan Zhuo, Jiaxi Peng, Shida Zhu, Lijian Zhao, Jian Wang, Li Wei, Zhaohong Shi, Zhaohong Shi   +26 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Second primary malignancies of cancer patients: treatment-related carcinogenesis

Успехи молекулярной онкологии, 2016
Cytostatic drugs used in chemotherapy cause secondary tumors in some patients cured of the antecedent neoplasm. Thus the incidence of second neoplasia for cancer survivors compared with the general population represents a 4-fold to 6-fold increased risk ...
G. A. Belitskiy, E. A. Lesovaya, K. I. Kirsanov, M. G. Yakubovskaya   +3 more
doaj   +1 more source

Genomic and epigenomic insights into the origin, pathogenesis and clinical behavior of mantle cell lymphoma subtypes.

Blood, 2020
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearrangement with two molecular subtypes, conventional (cMCL) and leukemic non-nodal (nnMCL), that differ in their clinicobiological behavior.
F. Nadeu, D. Martín-García, G. Clot, A. Díaz-Navarro, M. Duran-Ferrer, A. Navarro, Roser Vilarrasa-Blasi, M. Kulis, R. Royo, J. Gutiérrez-Abril, R. Valdés-Mas, C. López, V. Chapaprieta, Montserrat Puiggrós, G. Castellano, D. Costa, M. Aymerich, P. Jares, B. Espinet, A. Muntañola, Inmaculada Ribera‐Cortada, R. Siebert, D. Colomer, D. Torrents, E. Giné, A. López-Guillermo, R. Küppers, J. Martín-Subero, X. Puente, S. Beá, E. Campo   +30 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to GNAS and KRAS Status

Cancer Medicine
Background and Aim Pseudomyxoma peritonei (PMP) is an unusual condition with unique behaviour caused by a mucinous neoplasm, usually arising from the appendix.
Jane Gibson, Reuben J. Pengelly, Amatta Mirandari, Konstantinos Boukas, Sophia Stanford, Thomas Desmond Cecil, Faheez Mohamed, Sanjeev Paul Dayal, Alexios Tzivanakis, Brendan John Moran, Alex Mirnezami, Norman John Carr, Sarah Ennis   +12 more
doaj   +1 more source

Mismatch Repair (MMR) Status among Colorectal Cancer Patients in a Philippine Tertiary Hospital

Philippine Journal of Pathology
Background. Approximately 15% of colorectal cancers exhibit deficient mismatch repair (dMMR) status, and these cases have a better prognosis and are less prone to metastasis.
Rafael Anthon Nonato, Marissa Krizelda Santos   +1 more
doaj   +1 more source

FLT3-ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways

Haematologica, 2019
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm, and patients with an internal tandem duplication (ITD) mutation of the FMS-like tyrosine kinase-3 (FLT3) receptor gene have a poor prognosis.
Min Wu, Li Li, Max Hamaker, Donald Small, Amy S. Duffield   +4 more
doaj   +1 more source

Exceptional response to neoadjuvant capecitabine and temozolomide in TSC2-mutant pancreatic neuroendocrine tumor

Current Problems in Cancer: Case Reports, 2020
Tuberous Sclerosis 1/2 (TSC1/2) functions as a negative regulator of the mammalian target of rapamycin (mTOR) pathway, one of the key oncogenic pathways described in neuroendocrine neoplasm (NEN) carcinogenesis. While loss-of-function mutations in TSC1/2
Robin Park, Deyali Chatterjee, Manik Amin, Nikolaos A. Trikalinos   +3 more
doaj   +1 more source