Results 81 to 90 of about 479,747 (308)

Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to GNAS and KRAS Status

Cancer Medicine
Background and Aim Pseudomyxoma peritonei (PMP) is an unusual condition with unique behaviour caused by a mucinous neoplasm, usually arising from the appendix.
Jane Gibson, Reuben J. Pengelly, Amatta Mirandari, Konstantinos Boukas, Sophia Stanford, Thomas Desmond Cecil, Faheez Mohamed, Sanjeev Paul Dayal, Alexios Tzivanakis, Brendan John Moran, Alex Mirnezami, Norman John Carr, Sarah Ennis   +12 more
doaj   +1 more source

Population-based screening for colorectal cancer in Wuhan, China

Frontiers in Oncology
Fecal DNA test has emerged as a non-invasive alternative for colorectal cancer (CRC) screening in average-risk population. However, there is currently insufficient evidence in China to demonstrate the effectiveness of population-based CRC screening using
Song Liu, Song Liu, Yifan Wang, Yifan Wang, Yuying Wang, Chaofan Duan, Chaofan Duan, Fan Liu, Fan Liu, Heng Zhang, Xia Tian, Xiangwu Ding, Manling Zhang, Manling Zhang, Dan Cao, Dan Cao, Yi Liu, Yi Liu, Ruijingfang Jiang, Duan Zhuo, Jiaxi Peng, Shida Zhu, Lijian Zhao, Jian Wang, Li Wei, Zhaohong Shi, Zhaohong Shi   +26 more
doaj   +1 more source

Long Non-coding RNAs as Functional and Structural Chromatin Modulators in Acute Myeloid Leukemia

Frontiers in Oncology, 2019
Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood.
Alexander A. Wurm, Cristina Pina
doaj   +1 more source

DNA Repair Deficiency Associated with Hematological Neoplasms

, 2011
The genome of living organisms is constantly subjected to conditions that induce damage to DNA. A wide variety of DNA lesions are produced either as the result of normal metabolic processes or exogenous sources (ionizing radiation, UV light) (Seviour and Lin 2010).
Panagiota Economopoulou, Vassiliki Pappa, Sotirios Papageorgiou, John Dervenoulas, Theofanis Economopoulos   +4 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Mismatch Repair (MMR) Status among Colorectal Cancer Patients in a Philippine Tertiary Hospital

Philippine Journal of Pathology
Background. Approximately 15% of colorectal cancers exhibit deficient mismatch repair (dMMR) status, and these cases have a better prognosis and are less prone to metastasis.
Rafael Anthon Nonato, Marissa Krizelda Santos   +1 more
doaj   +1 more source

Clinical resistance to platinum chemotherapy in ovarian cancer [PDF]

, 2009
Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established.
Newton, C., Newton, C
core  

A Comprehensive Microarray-Based DNA Methylation Study of 367 Hematological Neoplasms

PLoS ONE, 2009
Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities, and comprehensive studies are required.Here, we report for the first time a microarray-based DNA methylation ...
Martin-Subero, Jose Ignacio, Ammerpohl, Ole, Bibikova, Marina, Wickham-Garcia, Eliza, Agirre, Xabier, Alvarez, Sara, Brüggemann, Monika, Bug, Stefanie, Calasanz, Maria J., Deckert, Martina, Dreyling, Martin, Du, Ming Q., Dürig, Jan, Dyer, Martin J. S., Fan, Jian-Bing, Gesk, Stefan, Hansmann, Martin-Leo, Harder, Lana, Hartmann, Sylvia, Klapper, Wolfram, Küppers, Ralf, Montesinos-Rongen, Manuel, Nagel, Inga, Pott, Christiane, Richter, Julia, Román-Gómez, José, Seifert, Marc, Stein, Harald, Suela, Javier, Trümper, Lorenz, Vater, Inga, Prosper, Felipe, Haferlach, Claudia, Cruz Cigudosa, Juan, Siebert, Reiner   +34 more
openaire   +8 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A comprehensive prognostic and immunological analysis of hexokinase domain containing protein-1 (HKDC1) in pan-cancer [PDF]

PeerJ
Background Currently, research on the role of hexokinase domain-containing protein-1 (HKDC1) in neoplasm metabolism remains sparse. This study seeks to conduct a thorough investigation of HKDC1’s potential functions across thirty-three different tumor ...
Zhi Liang, Tianhao Zhang, Jiajia Huang, Zhixin Huang, Zeyu Zhao, Shirong Cai, Jinping Ma   +6 more
doaj   +2 more sources