Results 71 to 80 of about 479,747 (308)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Angiosarcoma of the scalp associated with Xeroderma pigmentosum

Indian Journal of Medical and Paediatric Oncology, 2012
Xeroderma pigmentosum (XP) is a rare autosomal recessive genodermatosis associated with hypersensitivity to ultraviolet light due to defects in Deoxyribonucleic acid (DNA) repair.
Shilpi Sharma, Anuja D Deshmukh, Munita M Bal, Devendra A Chaukar, Anil K Dcruz   +4 more
doaj   +1 more source

DNA structures at chromosomal translocation sites

, 2006
It has been unclear why certain defined DNA regions are consistently sites of chromosomal translocations. Some of these are simply sequences of recognition by endogenous recombination enzymes, but most are not.
Raghavan, Sathees C., Lieber, Michael R.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

FLT3-ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways

Haematologica, 2019
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm, and patients with an internal tandem duplication (ITD) mutation of the FMS-like tyrosine kinase-3 (FLT3) receptor gene have a poor prognosis.
Min Wu, Li Li, Max Hamaker, Donald Small, Amy S. Duffield   +4 more
doaj   +1 more source

Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by dissemination to the bone marrow and other organs.
Chteinberg, Emil,, Busch, Hauke,, Fischer, Anja,, Witte, Hanno M., Sueltmann, Holger,, Schwarting, Julian,, Kusch, Kathrin, Schwarting, Julian, Fischer, Anja, von Bubnoff, Nikolas, Kuenstner, Axel, Lohneis, Philipp, Chteinberg, Emil, Lohneis, Philipp,, Salehi, Maede, Janke, Florian,, Stölting, Stephanie, Siebert, Reiner,, Bernard, Veronica, Salehi, Maede,, Merz, Hartmut, Kuenstner, Axel,, Chen, Xingqi,, Xing, Pengwei, Sueltmann, Holger, Siebert, Reiner, Gebauer, Niklas,, Künstner, Axel, Janke, Florian, Chen, Xingqi, Busch, Hauke, Xing, Pengwei,, Merz, Hartmut,, von Bubnoff, Nikolas,, Sültmann, Holger, Stoelting, Stephanie, Witte, Hanno M.,, WITTE, HANNO, Stoelting, Stephanie,, Bernard, Veronica,, Gebauer, Niklas, Feller, Alfred C., Kusch, Kathrin,, Feller, Alfred C.,   +43 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Exceptional response to neoadjuvant capecitabine and temozolomide in TSC2-mutant pancreatic neuroendocrine tumor

Current Problems in Cancer: Case Reports, 2020
Tuberous Sclerosis 1/2 (TSC1/2) functions as a negative regulator of the mammalian target of rapamycin (mTOR) pathway, one of the key oncogenic pathways described in neuroendocrine neoplasm (NEN) carcinogenesis. While loss-of-function mutations in TSC1/2
Robin Park, Deyali Chatterjee, Manik Amin, Nikolaos A. Trikalinos   +3 more
doaj   +1 more source

Analytical validation of a multi-cancer early detection test with cancer signal origin using a cell-free DNA-based targeted methylation assay.

PLoS ONE, 2023
The analytical validation is reported for a targeted methylation-based cell-free DNA multi-cancer early detection test designed to detect cancer and predict the cancer signal origin (tissue of origin).
Gregory E Alexander, Wendy Lin, Fabian E Ortega, Madhuvanthi Ramaiah, Byoungsok Jung, Lijuan Ji, Ekaterina Revenkova, Payal Shah, Christian Croisetiere, Jennifer R Berman, Lane Eubank, Gunjan Naik, Jacqueline Brooks, Andrea Mich, Seyedmehdi Shojaee, Neda Ronaghi, Hemanshi Chawla, Xinyi Hou, Qinwen Liu, Christopher-James A V Yakym, Patriss Wais Moradi, Meredith Halks-Miller, Alexander M Aravanis, Sonya Parpart-Li, Nathan Hunkapiller   +24 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source