Results 201 to 210 of about 315,433 (266)

Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability. [PDF]

Nat Commun
Gutierrez C, Kwok M, Ruthen N, Waddicor P, Curran C, Ouspenskaia T, Fu D, Smalec B, Sedor S, Knisbacher BA, Biran A, Nagler A, Garbicz F, Sewastianik T, Penailillo J, Lucas F, Yin S, Liani A, Chen S, Lazarian G, Witten E, Dangle N, Brunsting EL, Zheng M, Lin ES, Lee MJ, Wells B, Pomerance L, Hernández-Sánchez M, Li S, Lin Z, Al'Khafaji A, Wang L, Thakurela S, Livak KJ, Neuberg D, Cymbalista F, Getz G, Regev A, Churchman S, Ten Hacken E, Carrasco R, Shao S, Wu CJ.   +43 more
europepmc   +1 more source

Antechokinetics, the kinetics of antimicrobial resistance molecules. [PDF]

Front Pharmacol
Baquero F, Cantón R, Alves Gama J, Rodríguez-Beltrán J.   +3 more
europepmc   +1 more source

Analytical and clinical performance of in-house and commercial real-time PCR assays for diagnosing <i>L. infantum</i> visceral leishmaniasis: a study from a hub center in Northern Italy. [PDF]

J Clin Microbiol
Gritti T, Mola B, Argnani L, Granozzi B, Bacchiega M, Melchionda F, Dondi A, Nigrisoli G, Castaldini S, Prodi L, Lazzarotto T, Denwood M, Varani S, Ortalli M.   +13 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Profiling the Athletes' Gut Microbiome: A Critical Methodological Perspective on 16S Metabarcoding and Shotgun Metagenomics. [PDF]

Biology (Basel)
Carlone J, Ribeiro ÁCDS, Parisi A, Giampaoli S, Fasano A.   +4 more
europepmc   +1 more source

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Structural modeling and docking analysis of canonical and novel resistance-associated missense mutations in Sudanese Escherichia coli. [PDF]

Sci Rep
Sage EE, Ibrahim SAE, Firdaus-Raih M, Samhoon SOA, Mohamed AAM, Ahmed TME, Saadaldin MM, Suliman OH, Mohamed O, Mohamed SB, Ali QM.   +10 more
europepmc   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

Beyond Inhibition: Sublethal Rifampicin-Induced Molecular Adaptations Confer Phenotypic Drug Tolerance in Mycobacteria. [PDF]

ACS Infect Dis
Stuart BD, van der Merwe A, Chengalroyen MD, Moosa A, Warner DF, Blackburn JM, Ganief TA.   +6 more
europepmc   +1 more source