Results 91 to 100 of about 2,258,474 (352)
High-Mobility-Group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus Type 1 proviral promoter [PDF]
, 2000 HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner and with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces.
Henderson, A. +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Identifying the “stripe” transcription factors and cooperative binding related to DNA methylation
Communications BiologyDNA methylation plays a critical role in gene regulation by modulating the DNA binding of transcription factors (TFs). This study integrates TFs’ ChIP-seq profiles with WGBS profiles to investigate how DNA methylation affects protein interactions ...
Ximei Luo, Quan Zou
doaj +1 more source
Frontiers in Microbiology, 2012 Single-stranded DNA binding proteins play an essential role in DNA replication and repair. They use oligosaccharide-binding folds, a five-stranded ß-sheet coiled into a closed barrel, to bind to single-stranded DNA thereby protecting and stabilizing
Amy eStroud +2 more
doaj +1 more source
The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function [PDF]
, 2015 Poly (ADP-ribose) is synthesized at DNA single-strand breaks and can promote the recruitment of the scaffold protein, XRCC1. However, the mechanism and importance of this process has been challenged.
Breslin, Claire +6 more
core +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]
, 2006 DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J +5 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
To Bind or not to Bind: Understanding how CooA Activates [PDF]
, 2018 CooA, a gas-sensing heme protein found in several organisms, binds to DNA in the presence of carbon monoxide (CO) to regulate important metabolic functions.
Clark, Marcus, McGhiey, Celia
core +1 more source
Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA [PDF]
, 2015 SMC5/6 is a highly conserved protein complex related to cohesin and condensin, which are the key components of higher-order chromatin structures. The SMC5/6 complex is essential for proliferation in yeast and is involved in replication fork stability and
Adamus, Marek +10 more
core +2 more sources