Results 181 to 190 of about 54,943 (215)
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Repair of double-strand DNA breaks in Drosophila
Mutation Research, 1982This study describes the repair kinetics of DNA double-strand breaks in primary and established cell cultures of Drosophila melanogaster. Double-strand breaks, induced by X-irradiation, were monitored by neutral elution. In primary cell cultures 50% of the double-strand breaks induced by 10 kR of X-rays are repaired within 45 min and 80% of the breaks ...
W, Dezzani, P V, Harris, J B, Boyd
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DksA and DNA double-strand break repair
Current Genetics, 2019We use genetic assays to suggest that transcription-coupled repair or new origin formation in Escherichia coli involves removal of RNAP to create an RNA primer for DNA synthesis. Transcription factor DksA was shown to play a role in numerous reactions involving RNA polymerase.
Kamila K. Myka, Max E. Gottesman
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DNA Double-Strand Breaks and their Relation to Cytoxicity
1988In previous publications we have proposed that DNA double strand breaks were the crucial lesions leading to radiation induced cell death, chromosomal aberrations and mutations, and furthermore we have argued that the double strand breaks were induced according to linear-quadratic dose kinetics.
Chadwick, KH +3 more
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Regulation and Repair of Double-Strand DNA Breaks
Critical Reviews in Eukaryotic Gene Expression, 1996Double-strand break (DSB) repair in mammalian cells involves in DNA-dependent protein kinase (DNA-PK). DNA-PK is composed of three subunits, a catalytic kinase subunit (DNA-PKcs) mutated in the mouse scid complementation group and the Ku heterodimer. Ku-deficient and DNA-PKcs-deficient cell lines and an animal model have illuminated important features ...
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In Vitro Rejoining of Double Strand Breaks in Genomic DNA
2012Recent genetic and biochemical studies have provided important insights into the mechanism of nonhomologous end joining (NHEJ) pathways in higher eukaryotes, and have facilitated the functional characterization of several of its components including DNA-PKcs, Ku, DNA ligase IV, XRCC4, XLF/Cernunnos, and Artemis.
Iliakis, G., Mladenov, E., Cheong, N.
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Chromatin compartments at DNA double-stranded breaks
Cell Research, 2023Jaewon, Min, Jean, Gautier
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Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro
Nucleic Acids Research, 2020Xiaonong Zhang +2 more
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