Results 91 to 100 of about 108,714 (328)

Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues [PDF]

Proceedings of the National Academy of Sciences, 1999
Thus far, only one major form of vertebrate DNA (cytosine-5) methyltransferase (CpG MTase, EC 2.1.1.37 ) has been identified, cloned, and extensively studied. This enzyme, dnmt1, has been hypothesized to be responsible for most of the maintenance as well as the de novo methylation activities ...
D W, Hsu, M J, Lin, T L, Lee, S C, Wen, X, Chen, C K, Shen   +5 more
openaire   +2 more sources

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus [PDF]

Journal of Biological Chemistry, 2006
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of enduring cellular memory. Stable patterns of DNA methylation are established during development, resulting in creation of persisting cellular phenotypes. There is growing evidence that the nervous system has co-opted a number of cellular mechanisms used during development
Jonathan M, Levenson, Tania L, Roth, Farah D, Lubin, Courtney A, Miller, I-Chia, Huang, Priyanka, Desai, Lauren M, Malone, J David, Sweatt   +7 more
openaire   +2 more sources

Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment [PDF]

, 2015
Cancer inducible molecular chaperone HSP90 is of great importance as an anticancer target. Proteomic analysis showed that inhibiting HSP90 by the geldanamycin derivative, 17-AAG elevated the expression of the co-chaperone Hsp70.
Patil, Harshada Shashikant, Shervington, Amal A, Shervington, Leroy Alexander   +2 more
core   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics

Cell Reports, 2015
Ten eleven translocation (Tet) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC can be further excised by thymine-DNA glycosylase (Tdg).
Francesco Neri, Danny Incarnato, Anna Krepelova, Stefania Rapelli, Francesca Anselmi, Caterina Parlato, Claudio Medana, Federica Dal Bello, Salvatore Oliviero   +8 more
doaj   +1 more source

Fluorescence-based high-throughput assay for human DNA (cytosine-5)-methyltransferase 1 [PDF]

Analytical Biochemistry, 2010
We have developed the first economical and rapid nonradioactive assay method that is suitable for high-throughput screening of the important pharmacological target human DNA (cytosine-5)-methyltransferase 1 (DNMT1). The method combines three key innovations: the use of a truncated form of the enzyme that is highly active on a 26-bp hemimethylated DNA ...
Yu, Ye, James T, Stivers
openaire   +2 more sources

Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish [PDF]

, 2010
Background Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays
Canario, Adelino V. M., Matsumura, H., Pinto, Patricia IS, Power, Deborah, Reinhardt, Richard, Terauchi, Ryohei, Thorne, Michael A. S.   +6 more
core   +5 more sources

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Semi-quantitative proteomics of mammalian cells upon short-term exposure to nonionizing electromagnetic fields [PDF]

, 2017
The potential effects of non-ionizing electromagnetic fields (EMFs), such as those emitted by power-lines (in extremely low frequency range), mobile cellular systems and wireless networking devices (in radio frequency range) on human health have been ...
Bezstarosti, K. (Karel), Dekkers, D.H. (Dick), Demmers, J.A.A. (Jeroen), Eppink, B. (Berina), Kanaar, R. (Roland), Kuzniar, A. (Arnold), Laffeber, C., Lebbink, J.H.G. (Joyce), Woelders, H. (Henri), Zwamborn, A.P.M. (Adrianus)   +9 more
core   +1 more source