Results 41 to 50 of about 108,714 (328)
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids [PDF]
, 2012 A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids.
Bialkowski, Karol +9 more
core +1 more source
PLoS ONE, 2014 The epigenetic DNA modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in eukaryotes are recognized either in the context of double-stranded DNA (e.g., by the methyl-CpG binding domain of MeCP2), or in the flipped-out state (e.g., by ...
Evelina Zagorskaitė +1 more
doaj +1 more source
Chemical Science, 2020 DNA methylation at cytosine/guanine dinucleotide islands (CpGIs) is the most prominent epigenetic modification in prokaryotic and eukaryotic genomes. DNA methyltransferases (MTases) are responsible for genomic methylation, and their aberrant activities ...
Li-juan Wang +4 more
semanticscholar +1 more source
Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase [PDF]
Proceedings of the National Academy of Sciences, 2002 DNA methylation, various DNA repair mechanisms, and possibly early events in the opening of DNA as required for transcription and replication are initiated by flipping of a DNA base out of the DNA double helix. The energetics and structural mechanism of base flipping in the presence of the DNA-processing enzyme, cytosine 5 ...
Niu, Huang +2 more
openaire +2 more sources
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis [PDF]
, 2018 DNA methylation is an important epigenetic modification that is known to be altered in rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter DNA methylation of SF from patients with very early RA with SF from patients
Buckley, Christopher D +6 more
core +4 more sources
ComputationMetal-mediated base pairs in DNA double helix molecules open up broad opportunities for biosensors based on DNA clusters with silver due to their low toxicity and applicability in drug design.
Elena B. Gusarova, Natalya A. Kovaleva
doaj +1 more source
15N NMR study of a mixture of uniformly labeled tRNAs [PDF]
, 1982 15N NMR spectra were taken of 15N-enriched tRNA extracted from bakers yeast; ammonium sulfate was used as a nitrogen source. The increase in the degree of denaturation of tRNA, which occurs with increase in temperature from 30 degrees C to 70 degrees C ...
Birdseye, Theresa R. +3 more
core +1 more source
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. [PDF]
PLoS Genetics, 2017 Transcriptional silencing by heritable cytosine-5 methylation is an ancient strategy to repress transposable elements. It was previously thought that mammals possess four DNA methyltransferase paralogs-Dnmt1, Dnmt3a, Dnmt3b and Dnmt3l-that establish and ...
Devanshi Jain +7 more
doaj +1 more source
Discovery of Bacterial Deaminases That Convert 5-Fluoroisocytosine Into 5-Fluorouracil
Frontiers in Microbiology, 2018 Cytosine is one of the four letters of a standard genetic code, found both in DNA and in RNA. This heterocyclic base can be converted into uracil upon the action of the well-known cytosine deaminase.
Agota Aučynaitė +5 more
doaj +1 more source
Scientific Reports, 2023 DNA methylation is an epigenetic modification detected in both prokaryotic and eukaryotic genomic DNAs. In bacteria, the importance of 5-methylcytosine (m5C) in gene expression has been less investigated than in eukaryotic systems.
Annalisa Pisciotta +5 more
doaj +1 more source