Results 31 to 40 of about 94,090 (163)

The Effect of Sulphur Atom on the Structure of Biomolecule 2-Thiocytosine in the Gas-Phase, Solid-State, and Hydrated Forms and in DNA–DNA Microhelices as Compared to Canonical Ones

Molecules
This study is focused on the effects of the sulphur atom in position 2 of the cytosine molecule, 2-thiocytosine (2TC), on the molecular structural parameters in the isolated state, as well as in the hydration, solid state arrangement, Watson–Crick pairs,
Mauricio Alcolea Palafox, Valentin Alba Aparicio, Sergio Toninelli Rodriguez, Josefa Isasi Marín, Jitendra Kumar Vats, Vinod Kumar Rastogi   +5 more
doaj   +1 more source

Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

Biochemistry and Biophysics Reports, 2021
Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair.
Avani Mehta, Prateek Raj, Sandeep Sundriyal, Balasubramanian Gopal, Umesh Varshney   +4 more
doaj   +1 more source

CRISPR/Cas9-mediated phage resistance is not impeded by the DNA modifications of phage T4.

PLoS ONE, 2014
Bacteria rely on two known DNA-level defenses against their bacteriophage predators: restriction-modification and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated (Cas) systems.
Stephanie J Yaung, Kevin M Esvelt, George M Church   +2 more
doaj   +1 more source

A plant-based diet differentially affects the global hepatic methylome in rainbow trout depending on genetic background

Epigenetics, 2022
Replacing fish meal and oil in trout diets with plant-derived ingredients is a contemporary challenge to move towards more sustainable aquaculture practices.
Marandel L, Heraud C, Véron V, Laithier J, Marchand M, Quillet E, Callet T, Dupont-Nivet M, Médale F   +8 more
doaj   +1 more source

Mutation of a major CG methylase alters genome-wide lncRNA expression in rice

G3: Genes, Genomes, Genetics, 2021
Plant long non-coding RNAs (lncRNAs) function in diverse biological processes, and lncRNA expression is under epigenetic regulation, including by cytosine DNA methylation. However, it remains unclear whether 5-methylcytosine (5mOsMET1-2OsMET1-2−
Juzuo Li, Ning Li, Ling Zhu, Zhibin Zhang, Xiaochong Li, Jinbin Wang, Hongwei Xun, Jing Zhao, Xiaofei Wang, Tianya Wang, Hongyan Wang, Bao Liu, Yu Li, Lei Gong   +13 more
doaj   +1 more source

Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression

Epigenetics, 2017
Differentially methylated or hydroxymethylated regions (DMRs) in mammalian DNA are often associated with tissue-specific gene expression but the functional relationships are still being unraveled.
V. K. Chaithanya Ponnaluri, Kenneth C. Ehrlich, Guoqiang Zhang, Michelle Lacey, Douglas Johnston, Sriharsa Pradhan, Melanie Ehrlich   +6 more
doaj   +1 more source

Recent Progress in Electrochemical Biosensors for Detection of DNA Methylation and Methyltransferase Activity

International Journal of Electrochemical Science, 2019
DNA methylation is one of the most studied epigenetic modifications of DNA. The methylation at C-5 position of cytosine has been proved to be related to a wide range of biological phenomena. Therefore, it is very important to develop a simple, sensitive,
Ning Xia, Yuanqiang Hao
doaj   +1 more source

Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus [PDF]

Journal of Biological Chemistry, 2006
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of enduring cellular memory. Stable patterns of DNA methylation are established during development, resulting in creation of persisting cellular phenotypes. There is growing evidence that the nervous system has co-opted a number of cellular mechanisms used during development
Jonathan M, Levenson, Tania L, Roth, Farah D, Lubin, Courtney A, Miller, I-Chia, Huang, Priyanka, Desai, Lauren M, Malone, J David, Sweatt   +7 more
openaire   +2 more sources

Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field

iScience
Summary: 4-Methylcytosine (4mC) and 6-methyladenine (6mA) are the most prevalent types of DNA modifications in prokaryotes. However, whether there is crosstalk between 4mC and 6mA remain unknown.
Zhenhua Shi, Yingrong Zhang, Wanqiu Chen, Zhen Yu   +3 more
doaj   +1 more source

Scalable screening of ternary-code DNA methylation dynamics associated with human traits

Cell Genomics
Summary: Epigenome-wide association studies (EWASs) are transforming our understanding of the interplay between epigenetics and complex human traits.
David C. Goldberg, Cameron Cloud, Sol Moe Lee, Bret Barnes, Steven Gruber, Elliot Kim, Anita Pottekat, Maximillian S. Westphal, Luana McAuliffe, Elisa Majounie, Manesh Kalayil Manian, Qingdi Zhu, Christine Tran, Mark Hansen, Jelena Stojakovic, Jared B. Parker, Rahul M. Kohli, Rishi Porecha, Nicole Renke, Wanding Zhou   +19 more
doaj   +1 more source