Results 11 to 20 of about 94,067 (257)
eLife, 2021 Shotgun metagenomic sequencing is a powerful approach to study microbiomes in an unbiased manner and of increasing relevance for identifying novel enzymatic functions.
Weiwei Yang +9 more
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Mammalian DNA cytosine‐5 methyltransferase interacts with p23 protein [PDF]
FEBS Letters, 1996 In higher eukaryotic genomes, methylated cytosine residues (m5C) are distributed in heritable, cell‐type‐specific patterns, which are believed to be involved in the control of gene expression, developmental regulation and genomic imprinting. These methylation patterns are established and maintained by DNA cytosine‐5 methyltransferase (MTase), a ∼1500 ...
Zhang, Xiaoyan, Verdine, Gregory L.
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DNMT1 (DNA (cytosine-5-)-methyltransferase 1)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on DNMT1 (DNA (cytosine-5-)-methyltransferase 1)), with data on DNA, on the protein encoded, and where the gene is implicated.
Arai, E, Kanai, Y
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PLoS ONE, 2013 5-methylcytosine (5-mC) can be sequentially oxidized to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), and finally to 5-carboxylcytosine (5-caC), which is thought to function in active DNA cytosine demethylation in mammals. Although the roles
Xi-Wen Xing +6 more
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Epigenetics & Chromatin, 2018 Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao +5 more
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Changes in liver cell DNA methylation status in diabetic mice affect its FT-IR characteristics. [PDF]
PLoS ONE, 2014 Lower levels of cytosine methylation have been found in the liver cell DNA from non-obese diabetic (NOD) mice under hyperglycemic conditions. Because the Fourier transform-infrared (FT-IR) profiles of dry DNA samples are differently affected by DNA base ...
Benedicto de Campos Vidal +2 more
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Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase [PDF]
Proceedings of the National Academy of Sciences, 2002 DNA methylation, various DNA repair mechanisms, and possibly early events in the opening of DNA as required for transcription and replication are initiated by flipping of a DNA base out of the DNA double helix. The energetics and structural mechanism of base flipping in the presence of the DNA-processing enzyme, cytosine 5 ...
Niu, Huang +2 more
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Nature Communications, 2020 Circulating DNA detected in plasma can be used for diagnostic purposes. Here, the authors show that the 5-hydroxymethyl cytosine biomarker from plasma-derived cell free DNA can be used to detect early stage pancreatic cancer.
Gulfem D. Guler +15 more
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Intramolecular folding in human ILPR fragment with three C-rich repeats. [PDF]
PLoS ONE, 2012 Enrichment of four tandem repeats of guanine (G) rich and cytosine (C) rich sequences in functionally important regions of human genome forebodes the biological implications of four-stranded DNA structures, such as G-quadruplex and i-motif, that can form
Soma Dhakal +4 more
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Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA [PDF]
Nucleic Acids Research, 2012 DNA methyltransferases catalyse the transfer of a methyl group from the ubiquitous cofactor S-adenosyl-L-methionine (AdoMet) onto specific target sites on DNA and play important roles in organisms from bacteria to humans. AdoMet analogs with extended propargylic side chains have been chemically produced for methyltransferase-directed transfer of ...
G. Lukinavicius +4 more
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