Results 11 to 20 of about 95,440 (308)

DNMT1 (DNA (cytosine-5-)-methyltransferase 1)) [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on DNMT1 (DNA (cytosine-5-)-methyltransferase 1)), with data on DNA, on the protein encoded, and where the gene is implicated.
Arai, E, Kanai, Y
openaire   +2 more sources

Repeats as global DNA methylation marker in bovine preimplantation embryos [PDF]

open access: yes, 2017
DNA methylation undergoes dynamic changes and is a crucial part of the epigenetic regulation during mammalian early development. To determine the DNA methylation levels in bovine embryos, we applied a bisulfite sequencing based method aimed at repetitive
Li, Wenwen, Peelman, Luc, Van Soom, Ann
core   +2 more sources

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]

open access: yes, 2017
Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina   +3 more
core   +1 more source

Mammalian DNA cytosine‐5 methyltransferase interacts with p23 protein [PDF]

open access: yesFEBS Letters, 1996
In higher eukaryotic genomes, methylated cytosine residues (m5C) are distributed in heritable, cell‐type‐specific patterns, which are believed to be involved in the control of gene expression, developmental regulation and genomic imprinting. These methylation patterns are established and maintained by DNA cytosine‐5 methyltransferase (MTase), a ∼1500 ...
Zhang, Xiaoyan, Verdine, Gregory L.
openaire   +2 more sources

Investigations into the molecular effects of single nucleotide polymorphism [PDF]

open access: yes, 2000
Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe
core   +1 more source

Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer [PDF]

open access: yes, 2013
Change of DNA cytosine methylation (5mC) is an early event in the development of cancer, and the recent discovery of a 5-hydroxymethylated form (5hmC) of cytosine suggests a regulatory epigenetic role that might be different from 5-methylcytosine.
Matthias, Wielscher   +7 more
core   +1 more source

DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha) [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Kuo, YY, Li, LY, Tien, HF
openaire   +2 more sources

Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair [PDF]

open access: yes, 1992
The abundance of all tetra- and pentanucleotide sequences is calculated for a set of DNA sequence data comprising 767,393 nucleotides of the E. coli K-12 genome. Observed frequencies are compared to those expected from a Markov chain prediction algorithm.
Merkl, Rainer   +3 more
core   +1 more source

Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing.

open access: yesPLoS ONE, 2013
5-methylcytosine (5-mC) can be sequentially oxidized to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), and finally to 5-carboxylcytosine (5-caC), which is thought to function in active DNA cytosine demethylation in mammals. Although the roles
Xi-Wen Xing   +6 more
doaj   +1 more source

{BiQ} Analyzer {HiMod}: An Interactive Software Tool for High-throughput Locus-specific Analysis of 5-Methylcytosine and its Oxidized Derivatives [PDF]

open access: yes, 2014
Recent data suggest important biological roles for oxidative modifications of methylated cytosines, specifically hydroxymethylation, formylation and carboxylation. Several assays are now available for profiling these DNA modifications genome-wide as well
Becker, D.   +5 more
core   +2 more sources

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