Results 21 to 30 of about 94,067 (257)
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Frontiers in Genetics, 2018 Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants. Though much attention is given to the conventional epigenetic signature 5-methylcytosine (5-mC), the field of epigenetics is attracting ...
Suresh Kumar +2 more
doaj +1 more source
Fluorescent Method for the Detection of Biothiols Using an Ag+-Mediated Conformational Switch
Sensors, 2019 In this work, a novel, simple, and time-saving fluorescence approach for the detection of biothiols (glutathione and cysteine) was developed by employing a DNA probe labeled with 2-aminopurine.
Han Zhao, Mingjian Chen, Changbei Ma
doaj +1 more source
DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Kuo, YY, Li, LY, Tien, HF
openaire +2 more sources
PLoS ONE, 2014 The epigenetic DNA modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in eukaryotes are recognized either in the context of double-stranded DNA (e.g., by the methyl-CpG binding domain of MeCP2), or in the flipped-out state (e.g., by ...
Evelina Zagorskaitė +1 more
doaj +1 more source
ComputationMetal-mediated base pairs in DNA double helix molecules open up broad opportunities for biosensors based on DNA clusters with silver due to their low toxicity and applicability in drug design.
Elena B. Gusarova, Natalya A. Kovaleva
doaj +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. [PDF]
PLoS Genetics, 2017 Transcriptional silencing by heritable cytosine-5 methylation is an ancient strategy to repress transposable elements. It was previously thought that mammals possess four DNA methyltransferase paralogs-Dnmt1, Dnmt3a, Dnmt3b and Dnmt3l-that establish and ...
Devanshi Jain +7 more
doaj +1 more source
DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta), with data on DNA, on the protein encoded, and where the gene is implicated.
Ben, Gacem R +3 more
openaire +2 more sources
Discovery of Bacterial Deaminases That Convert 5-Fluoroisocytosine Into 5-Fluorouracil
Frontiers in Microbiology, 2018 Cytosine is one of the four letters of a standard genetic code, found both in DNA and in RNA. This heterocyclic base can be converted into uracil upon the action of the well-known cytosine deaminase.
Agota Aučynaitė +5 more
doaj +1 more source
Scientific Reports, 2023 DNA methylation is an epigenetic modification detected in both prokaryotic and eukaryotic genomic DNAs. In bacteria, the importance of 5-methylcytosine (m5C) in gene expression has been less investigated than in eukaryotic systems.
Annalisa Pisciotta +5 more
doaj +1 more source