Results 21 to 30 of about 95,440 (308)
DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta), with data on DNA, on the protein encoded, and where the gene is implicated.
Ben, Gacem R +3 more
openaire +2 more sources
Base Flip in DNA Studied by Molecular Dynamics Simulations of Differently-Oxidized Forms of Methyl-Cytosine [PDF]
, 2014 : Distortions in the DNA sequence, such as damage or mispairs, are specifically recognized and processed by DNA repair enzymes. Many repair proteins and, in particular, glycosylases flip the target base out of the DNA helix into the enzyme’s active site.
Helabad, Mahdi Bagherpoor +2 more
core +3 more sources
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Epigenetics & Chromatin, 2018 Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao +5 more
doaj +1 more source
Changes in liver cell DNA methylation status in diabetic mice affect its FT-IR characteristics. [PDF]
PLoS ONE, 2014 Lower levels of cytosine methylation have been found in the liver cell DNA from non-obese diabetic (NOD) mice under hyperglycemic conditions. Because the Fourier transform-infrared (FT-IR) profiles of dry DNA samples are differently affected by DNA base ...
Benedicto de Campos Vidal +2 more
doaj +1 more source
The contribution of Alu exons to the human proteome. [PDF]
, 2016 BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng +7 more
core +1 more source
Nature Communications, 2020 Circulating DNA detected in plasma can be used for diagnostic purposes. Here, the authors show that the 5-hydroxymethyl cytosine biomarker from plasma-derived cell free DNA can be used to detect early stage pancreatic cancer.
Gulfem D. Guler +15 more
doaj +1 more source
Intramolecular folding in human ILPR fragment with three C-rich repeats. [PDF]
PLoS ONE, 2012 Enrichment of four tandem repeats of guanine (G) rich and cytosine (C) rich sequences in functionally important regions of human genome forebodes the biological implications of four-stranded DNA structures, such as G-quadruplex and i-motif, that can form
Soma Dhakal +4 more
doaj +1 more source
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome [PDF]
, 2019 DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability.
Allison, Rachal M +5 more
core +1 more source
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Frontiers in Genetics, 2018 Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants. Though much attention is given to the conventional epigenetic signature 5-methylcytosine (5-mC), the field of epigenetics is attracting ...
Suresh Kumar +2 more
doaj +1 more source