Results 51 to 60 of about 108,714 (328)

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Environmentally sensitive molecular probes reveal mutations and epigenetic 5-methyl cytosine in human oncogenes [PDF]

, 2017
There is currently an unmet need for reliable tools that allow for direct detection and quantification of modifications in genomic DNA.
Astakhova, K., Barducci, M. C., Taskova, M.   +2 more
core   +2 more sources

5-bromo- and 5-iodo-N-1-sulfonylated cytosine derivatives. Exclusive formation of keto-imino tautomers [PDF]

, 1999
N-1-Sulfonylated cytosine 5 and 5-halogeno-N-1-sulfonylated cytosine derivatives 1 and 2 were synthesized by condensation of silylated cytosine or 5-halogenocytosine bases with tosylchloride in acetonitrile, or by the reaction of cytosine or 5 ...
Krizmanić, Irena, Vikić-Topić, Dražen, Žinić, Biserka, Žinić, Mladen   +3 more
core   +1 more source

Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas [PDF]

, 2017
5-Hydroxymethylcytosine (5hmC) is an important, yet poorly understood epigenetic DNA modification, especially in invertebrates. Aberrant genome-wide 5hmC levels have been associated with cadmium (Cd) exposure in humans, but such information is lacking ...
A Garcia, A Gomot, A Itziou, A Itziou, A Murata, A Sanders, ATSDR, B Wang, C Zhang, CJ Pirola, Cristina Popescu, CW Hanna, D Globisch, D Strepetkaite, DJ Spurgeon, Dragos Nica, DV Nica, E Hödl, EM Rasmussen, European Comission, F Gimbert, F Gimbert, F Hispard, F Lyko, F Pierron, G Jiang, G Riviere, George Draghici, H Wang, I Feliciello, Ionela Privistirescu, J Liu, J Zhang, JA Head, Jörg Oehlmann, LK Russell, LL Moroz, LL Moroz, M Coeurdassier, M Höckner, M Notten, M Takiguchi, M Tellez-Plaza, Marek Wojciechowski, Maria Suciu, MB Hossain, MP Kerney, MR Branco, P Cingolani, PA Jones, PE Baurand, PW Hill, R Dallinger, R Dallinger, R Dallinger, R Dallinger, R Kucharski, R Laskowski, RD Hood, Reinhard Stöger, RM Erdmann, S Fneich, S Lian, S Pells, S Wattanaphansak, T Dao, W Li, WB Rabitsch, Y Bergman, Òscar Palacios   +69 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with graphene oxide [PDF]

, 2014
Metal containing polymers have expanded the property of polymers by involving covalently associated metal complexes. DNA is a special block copolymer.
Liu, Juewen, Wang, Feng
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

The Effect of Sulphur Atom on the Structure of Biomolecule 2-Thiocytosine in the Gas-Phase, Solid-State, and Hydrated Forms and in DNA–DNA Microhelices as Compared to Canonical Ones

Molecules
This study is focused on the effects of the sulphur atom in position 2 of the cytosine molecule, 2-thiocytosine (2TC), on the molecular structural parameters in the isolated state, as well as in the hydration, solid state arrangement, Watson–Crick pairs,
Mauricio Alcolea Palafox, Valentin Alba Aparicio, Sergio Toninelli Rodriguez, Josefa Isasi Marín, Jitendra Kumar Vats, Vinod Kumar Rastogi   +5 more
doaj   +1 more source

Mutation of a major CG methylase alters genome-wide lncRNA expression in rice

G3: Genes, Genomes, Genetics, 2021
Plant long non-coding RNAs (lncRNAs) function in diverse biological processes, and lncRNA expression is under epigenetic regulation, including by cytosine DNA methylation. However, it remains unclear whether 5-methylcytosine (5mOsMET1-2OsMET1-2−
Juzuo Li, Ning Li, Ling Zhu, Zhibin Zhang, Xiaochong Li, Jinbin Wang, Hongwei Xun, Jing Zhao, Xiaofei Wang, Tianya Wang, Hongyan Wang, Bao Liu, Yu Li, Lei Gong   +13 more
doaj   +1 more source