Results 21 to 30 of about 976,559 (349)

DNA Damage/Repair Management in Cancers

Cancers, 2020
DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.
Jehad F Alhmoud, J. Woolley, A. Al Moustafa, M. I. Malki   +3 more
semanticscholar   +1 more source

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Genetic variants in genes involved in maintenance of genomic stability are modifiers of Huntington’s disease (HD) age of onset. This study shows a connection between the E3 SUMO ligase PIAS1, DNA damage repair protein PNKP, and HD-associated
Eva L. Morozko, Charlene Smith-Geater, A. M. Monteys, Subrata Pradhan, Ryan G. Lim, P. Langfelder, Marketta Kachemov, A. Hill, Jennifer T. Stocksdale, P. Cullis, Jie Wu, Joseph Ochaba, Ricardo Miramontes, Anirban Chakraborty, T. Hazra, Alice L. Lau, S. St-cyr, Iliana Orellana, L. Kopan, Keona Q. Wang, Sylvia Y. Yeung, B. Leavitt, Jack C. Reidling, X. W. Yang, J. Steffan, B. Davidson, P. Sarkar, L. Thompson   +27 more
semanticscholar   +1 more source

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives

Gut, 2020
Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years.
L. Perkhofer, J. Gout, E. Roger, Fernando Kude de Almeida, Carolina Baptista Simões, L. Wiesmüller, T. Seufferlein, A. Kleger   +7 more
semanticscholar   +1 more source

OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair

Cell Death and Disease, 2021
Accumulated evidence shows that OGT-mediated O-GlcNAcylation plays an important role in response to DNA damage repair. However, it is unclear if the “eraser” O-GlcNAcase (OGA) participates in this cellular process.
Yaqi Cui, Rong Xie, Xue-fang Zhang, Yi Liu, Yixuan Hu, Yuan Li, Xiuhua Liu, Xiaochun Yu, Chen Wu   +8 more
semanticscholar   +1 more source

Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation

Cell Death and Disease, 2023
DNA repair is a tightly coordinated stress response to DNA damage, which is critical for preserving genome integrity. Accruing evidence suggests that metabolic pathways have been correlated with cellular response to DNA damage.
Seungyeon Yang, Sunsook Hwang, Byungjoo Kim, Seungmin Shin, Minjoong Kim, Seung Min Jeong   +5 more
doaj   +1 more source

Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures

DNA, 2022
Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can
Tonia T. Li, Karen M. Vasquez
doaj   +1 more source

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

eLife, 2019
Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl   +5 more
doaj   +1 more source

Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma

Frontiers in Oncology, 2022
Cells experience both endogenous and exogenous DNA damage daily. To maintain genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a series of repair functions, termed DNA damage response (DDR), to repair DNA damage and ...
Huimin Lei, Ading He, Yingying Jiang, Min Ruan, Min Ruan, Min Ruan, Nannan Han, Nannan Han   +7 more
doaj   +1 more source

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]

, 2020
Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe, García Domínguez, Mario, Herrero Ruiz, Andrés M., Moreno Oñate, Marta, Ruiz Pérez, José Francisco   +4 more
core   +1 more source

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

Nature Communications, 2020
DNA damage contributes to brain aging and neurodegenerative diseases. However, the factors stimulating DNA repair to stave off functional decline remain obscure. We show that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) repair in the brain.
P. Pao, P. Pao, D. Patnaik, L. A. Watson, L. A. Watson, Fan Gao, Fan Gao, Fan Gao, Ling Pan, Ling Pan, Jun Wang, Jun Wang, Chinnakkaruppan Adaikkan, Chinnakkaruppan Adaikkan, Jay Penney, Jay Penney, Hugh P Cam, Hugh P Cam, Wen-Chin Huang, Wen-Chin Huang, Lorena Pantano, Lorena Pantano, Audrey Lee, Audrey Lee, Alexi Nott, Alexi Nott, Alexi Nott, Trongha X. Phan, Trongha X. Phan, Elizabeta Gjoneska, Elizabeta Gjoneska, Elizabeta Gjoneska, Sara Elmsaouri, Sara Elmsaouri, S. Haggarty, Li-Huei Tsai, Li-Huei Tsai   +36 more
semanticscholar   +1 more source