Results 21 to 30 of about 1,030,824 (346)
DNA Damage/Repair Management in Cancers
Cancers, 2020 DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.
Jehad F Alhmoud +3 more
semanticscholar +1 more source
Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation
Cell Death and Disease, 2023 DNA repair is a tightly coordinated stress response to DNA damage, which is critical for preserving genome integrity. Accruing evidence suggests that metabolic pathways have been correlated with cellular response to DNA damage.
Seungyeon Yang +5 more
doaj +1 more source
DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
Gut, 2020 Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years.
L. Perkhofer +7 more
semanticscholar +1 more source
RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]
, 2020 Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe +4 more
core +1 more source
eLife, 2019 Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot +5 more
doaj +1 more source
Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures
DNA, 2022 Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can
Tonia T. Li, Karen M. Vasquez
doaj +1 more source
Nucleic Acids Research, 2020 The genetic etiology of premature ovarian insufficiency (POI) has been well established to date, however, the role of long noncoding RNAs (lncRNAs) in POI is largely unknown.
Xiaoyan Wang +9 more
semanticscholar +1 more source
eLife, 2018 TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus act
Matthew Day +5 more
doaj +1 more source
Frontiers in Oncology, 2022 Cells experience both endogenous and exogenous DNA damage daily. To maintain genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a series of repair functions, termed DNA damage response (DDR), to repair DNA damage and ...
Huimin Lei +7 more
doaj +1 more source
DNA Damage, Repair, and Diseases [PDF]
BioMed Research International, 2002 DNA is the essential carrier of genetic information in all living cells. How is the huge amount of DNA in organisms from bacteria to humans maintained and protected from the ravages of noxious agents in the environment? The chemical stability of the DNA molecule is not unusually great, DNA undergoes several types of spontaneous modifications, and it ...
Wiesmüller, Lisa +2 more
openaire +2 more sources