Results 191 to 200 of about 1,846,477 (392)

Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells [PDF]

, 2021
Tonghui Bi, Xiaohong Niu, Chunping Qin, Wei Xiao   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A novel DNA damage detection method based on a distinct DNA damage response system

Microbial Biotechnology
DNA damage occurs when cells encounter exogenous and endogenous stresses such as long periods of desiccation, ionizing radiation and genotoxic chemicals.
Shitong Zhong, Shuang Song, Linjia Wang, Yufeng Liu, Hong Xu, Liangyan Wang, Huizhi Lu, Yuejin Hua   +7 more
doaj   +1 more source

DNA damage response and cell cycle regulation in bacteria: a twist around the paradigm

Frontiers in Microbiology
The co-protease activity in the RecA-ssDNA complex cleaves the autorepressor LexA, resulting in the derepression of a large number of genes under LexA control.
Hari Sharan Misra, Yogendra Singh Rajpurohit, Yogendra Singh Rajpurohit   +2 more
doaj   +1 more source

MOESM1 of A potential role for protein palmitoylation and zDHHC16 in DNA damage response

, 2016
Na Cao, Jia-Kai Li, Yuqing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng, Jing Li   +8 more
openalex   +2 more sources

Targeting the DNA Damage Response to Increase Anthracycline-Based Chemotherapy Cytotoxicity in T-Cell Lymphoma [PDF]

, 2022
Martina Magni, Chiara Paolizzi, Chiara Monfrini, Cristina Vella, Paolo Corradini, Cristiana Carniti   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Ubiquitin Ligase Activity in the DDB2 and CSA Complexes Is Differentially Regulated by the COP9 Signalosome in Response to DNA Damage [PDF]

, 2003
Regina Groisman, Jolanta Polanowska, Isao Kuraoka, Jun‐ichi Sawada, Masafumi Saijo, Ronny Drapkin, Alexei F. Kisselev, Kiyoji Tanaka, Yoshihiro Nakatani   +8 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo [PDF]

, 2013
Sandra Morandell, Hans Christian Reinhardt, Ian G. Cannell, Jacob S. Kim, Daniela M. Ruf, Tanya Mitra, Anthony D. Couvillon, Tyler Jacks, Michael B. Yaffe   +8 more
openalex   +1 more source