Results 201 to 210 of about 1,846,477 (392)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The relationship between DNA single-stranded damage response and double-stranded damage response [PDF]

, 2017
Aiqing Ma, Xianhua Dai
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

The multifaceted world of the DNA damage response

Frontiers in Genetics, 2016
Antonio ePorro
doaj   +1 more source

The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation

Cell Death and Disease
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and consequently mRNA translation elongation, in response to hypoxia and nutrient deprivation. EEF2K is also involved in
Jonathan K. M. Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J. Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H. Sorensen   +11 more
doaj   +1 more source

Dmp53 Activates the Hippo Pathway to Promote Cell Death in Response to DNA Damage [PDF]

, 2006
Julien Colombani, Cédric Polesello, Filipe Josué, Nicolas Tapon   +3 more
openalex   +1 more source

Association Between DNA Damage Response, Fibrosis and Type I Interferon Signature in Systemic Sclerosis [PDF]

, 2020
Nikolaos I. Vlachogiannis, Μαρία Παππά, Panagiotis A. Ntouros, Adrianos Nezos, Clio P. Mavragani, Vassilis L. Souliotis, Petros P. Sfikakis   +6 more
openalex   +1 more source

Supplementary Figure 4 from Functional Interplay of p53 and Mus81 in DNA Damage Responses and Cancer [PDF]

, 2023
Ashwin Pamidi, Renato Cardoso, Anne Hakem, Elzbieta Matysiak‐Zablocki, Anuradha Poonepalli, Laura Tamblyn, Bayardo Perez‐Ordoñez, M. Prakash Hande, Otto Sánchez, Razqallah Hakem   +9 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source