Results 231 to 240 of about 1,846,477 (392)

Multiple myeloma risk linked to DNA damage response genes. [PDF]

J Hematol Oncol
Conry M, Ostrovnaya I, Kemel Y, Sinha S, Baughn LB, Avery B, Maclachlan K, Groner V, Banaszak L, Norman A, Boddicker NJ, Clay-Gilmour A, Kumar S, Kim E, Dandiker S, Waghmare M, Slager S, Sborov DW, Garber J, Brown EE, Hildebrandt M, Hari P, Camp N, Vachon C, Usmani S, Offit K, Joseph V.   +26 more
europepmc   +1 more source

The human intra-S checkpoint response to UVC-induced DNA damage [PDF]

, 2009
William K. Kaufmann
openalex   +1 more source

Cytolethal Distending Toxin: from mitotic DNA damage to cGAS-dependent pro-inflammatory response [PDF]

, 2020
Benoît J. Pons, Aurélie Pettes-Duler, Claire Naylies, Frédéric Taïeb, Saleha Hashim, Soraya Tadrist, Yannick Lippi, Gladys Mirey, Julien Vignard   +8 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Thyroid Hormone T3 Induces DNA Damage Response in Breast Cancer Cells. [PDF]

Int J Mol Sci
Movshovitz S, Sinberger LA, Trabelsi K, Bar-On A, Sonnenblick A, Salmon-Divon M, Listovsky T.   +6 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition. [PDF]

Front Cell Dev Biol
Giuntini F, Whitfield JR, Massó-Vallés D, Soucek L.   +3 more
europepmc   +1 more source

Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: Transcriptional regulation and DNA damage response

, 2020
Elżbieta Poręba, Julia Durzyńska
openalex   +1 more source

DNA2—An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein? [PDF]

, 2017
Elżbieta Pawłowska, Joanna Szczepańska, Janusz Błasiak   +2 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source