Results 171 to 180 of about 96,036 (271)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, Volume 59, Issue 4, Page 590-613, April 2026.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

A Nanoparticle-Based Strategy to Stabilize 5-Azacytidine and Preserve DNA Demethylation Activity in Human Cardiac Fibroblasts. [PDF]

Pharmaceutics
Kheawfu K, Chittasupho C, Singh S, Okonogi S, Karuna N.   +4 more
europepmc   +1 more source

Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience

New Phytologist, Volume 250, Issue 2, Page 762-787, April 2026.
Summary B‐box (BBX) proteins were initially characterized as transcription factors connecting light signaling to the regulation of flowering time and seedling photomorphogenesis. However, over the last decade, increasing evidence has shown that they integrate light and hormone signaling, modulating multiple physiological processes during plant life. In
Bruno Silvestre Lira, Juliene Moreira, Luciano Freschi, Magdalena Rossi   +3 more
wiley   +1 more source

Loss of TET2 activity limits the ability of vitamin C to activate DNA demethylation in human HAP1 cells. [PDF]

Epigenetics Chromatin
Gawronski M, Starczak M, Wasilow A, Dziaman T, Olinski R, Gackowski D.   +5 more
europepmc   +1 more source

Structure, function and regulation of mammalian DNA methyltransferase [PDF]

, 1993
A Bolden, A Czank, A Lahm, AD Riggs, C. Lange, D Jahner, D Simon, D. Ingrosso, DV Santi, E Flatau, E Li, F Antequera, F Antequera, GP Pfeifer, GP Pfeifer, GP Pfeifer, J Posfai, J-P Jost, JC Wu, JR Chaillet, K. K. Hubrich, KE Zucker, KR Fox, L Chen, LA Sznyter, M Monk, M Monk, MN Schwartz, P Engler, P Renbaum, R Holliday, R. Lauster, RL Adams, RLP Adams, RR Meehan, S Klimasauskas, SK Howlett, SL Mansour, T Bestor, T Bestor, T Bestor, T Bestor, TH Bestor, TH Bestor, Y Gruenbaum, Y Gruenbaum, Y Uehara   +46 more
core   +1 more source

Mild Photoperiod and Temperature Fluctuations Elicit Tissue‐Specific DNA Methylation Changes in Arabidopsis

Plant, Cell &Environment, EarlyView.
Ji Hoon Rhee, Hyogi Kim, Hyodong Lee, Yunji Jeon, Yeonhee Choi   +4 more
wiley   +1 more source

Linking Superoxide Production and Scavenging in Plant Development

Plant, Cell &Environment, Volume 49, Issue 4, Page 2048-2068, April 2026.
ABSTRACT Due to their strong oxidizing potential, rapid membrane permeability, and high reactivity, reactive oxygen species (ROS) play essential roles in plant development and stress responses. Superoxide (O2•‐) is a primary product of molecular oxygen reduction and a crucial source of hydrogen peroxide, representing a ROS species of substantial ...
Jan Řehák, Maryna Tsinyk, Petr Dvořák, Tomáš Takáč   +3 more
wiley   +1 more source

DNA demethylation-mediated downregulation of MNX1 in acute myeloid leukemia. [PDF]

Leukemia
Kelekçi S, Kelly K, Goyal A, Wehrwein N, Riedel A, Weichenhan D, Scherer M, Michels BE, Körner C, Orzella I, Hakobyan M, Bähr M, Everatt E, Dunford J, Lipka DB, Lutsik P, Oppermann U, Plass C.   +17 more
europepmc   +1 more source