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Measurement of Apoptosis by DNA Fragmentation
2004Classical apoptotic cell death can be defined by certain morphological and biochemical characteristics that distinguish it from other forms of cell death. One such feature, which is a hallmark of apoptosis, is DNA fragmentation. In dying cells, DNA is cleaved by an endonuclease that fragments the chromatin into nucleosomal units, which are multiples of
Demetrius, Matassov +4 more
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Nucleosomal DNA Fragments in Autoimmune Diseases
Annals of the New York Academy of Sciences, 2006Abstract: The inadequate response of immune cells to circulating apoptotic products, such as nucleosomal DNA fragments, is assumed to be a potent stimulus for the production of autoantibodies during the pathogenesis and progression of systemic lupus erythematosus (SLE). Here, we analyzed the levels of circulating nucleosomes, caspases, and C‐reactive
Holdenrieder, Stefan +7 more
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Radiolabeling of DNA with the Klenow Fragment of DNA Polymerase
2003The Klenow fragment of DNA polymerase I is a proteolytic fragment obtained by the treatment of DNA polymerase I with subtilisin. The fragment still has the polymerase and 3'-5' exonuclease activity, but lacks the 5'-3' exonuclease activity of the holoenzyme (1). Radiolabeling of DNA fragments is most efficient with DNA fragments that contain recessed 3'
W, Gaastra, J, Josephsen
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Sperm DNA Fragmentation and Fertility
Elevated levels of sperm deoxyribonucleic acid (DNA) fragmentation (SDF) have been associated with several adverse reproductive outcomes, including: lower natural and assisted reproductive technology (ART) pregnancy rates, abnormal embryo development, and recurrent pregnancy loss.Jessica, Marinaro, Peter N, Schlegel
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The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB
American Journal of Human Genetics, 2020Rossa Chiu, Kathy O Lui, Meng Ni
exaly
Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations
Andrologia, 2021Sheena Lewis +2 more
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Fragmentation of DNA in morphologically normal human spermatozoa
Fertility and Sterility, 2009Sérgio Oehninger +2 more
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