Results 1 to 10 of about 1,983,411 (100)

Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells

Journal of Biological Chemistry, 2020
Infection with the Gram-negative, microaerophilic bacterium Helicobacter pylori induces an inflammatory response and oxidative DNA damage in gastric epithelial cells that can lead to gastric cancer (GC).
I. Sayed, A. Şahan, T. Venkova, Anirban Chakraborty, Dibyabrata Mukhopadhyay, D. Bimczok, E. Beswick, V. Reyes, I. Pinchuk, D. Sahoo, P. Ghosh, T. Hazra, Soumita Das   +12 more
semanticscholar   +1 more source

The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

Nature Communications, 2020
Efficient search for DNA damage embedded in vast expanses of the DNA genome presents one of the greatest challenges to DNA repair enzymes. We report here crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase, hOGG1, that interact with the DNA ...
U. Shigdel, V. Ovchinnikov, Seung-Joo Lee, Jenny A Shih, M. Karplus, K. Nam, G. Verdine   +6 more
semanticscholar   +1 more source

Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity

eLife, 2016
Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The
A. Wibowo, C. Becker, G. Marconi, Julius Durr, Jonathan Price, J. Hagmann, Ranjith K. Papareddy, H. Putra, J. Kageyama, J. Becker, D. Weigel, J. Gutierrez-Marcos   +11 more
semanticscholar   +1 more source

Terminal Deoxynucleotidyl Transferase and T7 Exonuclease-Aided Amplification Strategy for Ultrasensitive Detection of Uracil-DNA Glycosylase.

Analytical Chemistry, 2018
As one of the key initiators of the base excision repair process, uracil-DNA glycosylase (UDG) plays an important role in maintaining genomic integrity. It has been found that aberrant expression of UDG is associated with a variety of diseases.
Yichen Du, Yunxi Cui, Xiaoyu Li, Guo-Ying Sun, Yu-Peng Zhang, An-Na Tang, Kwangil Kim, Deming Kong   +7 more
semanticscholar   +1 more source

Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase.

Journal of the American Chemical Society, 2018
The activity of DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1), which excises oxidized base 8-oxoguanine (8-OG) from DNA, is closely linked to mutagenesis, genotoxicity, cancer, and inflammation.
Y. Tahara, D. Auld, D. Ji, Andrew A Beharry, A. Kietrys, David L. Wilson, Marta Jimenez, D. King, Zachary Nguyen, E. Kool   +9 more
semanticscholar   +1 more source

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression*

Journal of Biological Chemistry, 2016
A large percentage of redox-responsive gene promoters contain evolutionarily conserved guanine-rich clusters; guanines are the bases most susceptible to oxidative modification(s).
L. Pan, B. Zhu, W. Hao, Xianlu Zeng, S. Vlahopoulos, T. Hazra, M. Hegde, Z. Radák, A. Bácsi, A. Brasier, Xueqing Ba, I. Boldogh   +11 more
semanticscholar   +1 more source

Excision Repair-Initiated Enzyme-Assisted Bicyclic Cascade Signal Amplification for Ultrasensitive Detection of Uracil-DNA Glycosylase.

Analytical Chemistry, 2017
Uracil-DNA glycosylase (UDG) is an important base excision repair (BER) enzyme responsible for the repair of uracil-induced DNA lesion and the maintenance of genomic integrity, while the aberrant expression of UDG is associated with a variety of cancers.
Li-juan Wang, Ming Ren, Qianyi Zhang, Bo Tang, Chun-yang Zhang   +4 more
semanticscholar   +1 more source

AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site Product.

Biochemistry, 2017
A major product of oxidative DNA damage is 8-oxoguanine. In humans, 8-oxoguanine DNA glycosylase (hOGG1) facilitates removal of these lesions, producing an abasic (AP) site in the DNA that is subsequently incised by AP-endonuclease 1 (APE1).
Alexandre Esadze, Gaddiel Rodriguez, Shannen L. Cravens, J. Stivers   +3 more
semanticscholar   +1 more source

Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.

Biochemistry, 2016
Thymine DNA glycosylase (TDG) is a base excision repair enzyme with key functions in epigenetic regulation. Performing a critical step in a pathway for active DNA demethylation, TDG removes 5-formylcytosine and 5-carboxylcytosine, oxidized derivatives of
L. Pidugu, Joshua W. Flowers, Christopher T. Coey, E. Pozharski, M. Greenberg, A. Drohat   +5 more
semanticscholar   +1 more source

A Catalytic Role for C-H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD.

Journal of the American Chemical Society, 2016
DNA glycosylases protect genomic integrity by locating and excising aberrant nucleobases. Substrate recognition and excision usually take place in an extrahelical conformation, which is often stabilized by π-stacking interactions between the lesion ...
Zachary D. Parsons, J. Bland, E. Mullins, B. Eichman   +3 more
semanticscholar   +1 more source