Results 21 to 30 of about 1,564,144 (179)

Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

Biochemistry and Biophysics Reports, 2021
Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair.
Avani Mehta, Prateek Raj, Sandeep Sundriyal, Balasubramanian Gopal, Umesh Varshney   +4 more
doaj   +1 more source

Inhibition of DNA glycosylases via small molecule purine analogs. [PDF]

PLoS ONE, 2013
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed.
Aaron C Jacobs, Marcus J Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd   +9 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome

Cell Discovery, 2023
The engagement of a DNA glycosylase with a damaged DNA base marks the initiation of base excision repair. Nucleosome-based packaging of eukaryotic genome obstructs DNA accessibility, and how DNA glycosylases locate the substrate site on nucleosomes is ...
Lvqin Zheng, Bin Tsai, Ning Gao
doaj   +1 more source

Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process

Acta Biochimica et Biophysica Sinica, 2022
DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways ...
Wang Lingyan, Song Kaiyuan, Yu Jin, Da Lin-Tai   +3 more
doaj   +1 more source

Characterization of a conserved interaction between DNA glycosylase and ParA in Mycobacterium smegmatis and M. tuberculosis. [PDF]

PLoS ONE, 2012
The chromosome partitioning proteins, ParAB, ensure accurate segregation of genetic materials into daughter cells and most bacterial species contain their homologs. However, little is known about the regulation of ParAB proteins.
Feng Huang, Zheng-Guo He
doaj   +1 more source

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Biomolecules, 2020
8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision repair.
Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz   +2 more
doaj   +1 more source

Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297)

Biochemistry and Biophysics Reports, 2017
Nei2 (Rv3297) is a DNA Base Excision Repair (BER) glycosylase that is essential for survival of Mycobacterium tuberculosis in primates. We show that MtbNei2 is a bifunctional glycosylase that specifically acts on oxidized pyrimidine-containing single ...
Kiran Lata, Mohammad Afsar, Ravishankar Ramachandran   +2 more
doaj   +1 more source

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]

, 2010
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
R. Rozalski, A. Szpila, B. Tudek, Speina, Elzbieta, Oliński, Ryszard, Janowska, Beata, J. Janik, Obtułowicz, Tomasz, Janik, Justyna, T. Dziaman, Dziaman, Tomasz, Szpila, Anna, J. M. Ciesla, Siomek, Agnieszka, A. Siomek, Cieśla, Jarosław M., Jawien, Arkadiusz, Gackowski, Daniel, M. Swoboda, E. Speina, R. Olinski, Swoboda, Maja, D. Gackowski, Guz, Jolanta, B. Janowska, J. Guz, Z. Banaszkiewicz, A. Jawien, Rozalski, Rafał, T. Obtulowicz, Tudek, Barbara, Banaszkiewicz, Zbigniew   +31 more
core   +2 more sources

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]

, 2013
Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
Cole, Ambrose R., Savva, Renos, Baltulionis, Gediminas, Ofer, S, Hornyak, P, Ryzhenkova, K, Baltulionis, G, Cole, AR, Ofer, Sapir, Savva, R, Ryzhenkova, Ksenia, Hornyak, Peter   +11 more
core   +1 more source