Results 31 to 40 of about 1,564,144 (179)

A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus [PDF]

open access: yes, 2012
The removal of chemically damaged DNA bases such as 3-methyladenine (3-MeA) is an essential process in all living organisms and is catalyzed by the enzyme 3-MeA DNA glycosylase I.
Zhu, Xiaofeng   +7 more
core   +1 more source

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

open access: yesFrontiers in Immunology, 2019
Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil.
Ryan Costello   +2 more
doaj   +1 more source

A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]

open access: yes, 2013
The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core   +1 more source

An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected]. [PDF]

open access: yesPLoS Genetics, 2015
Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases.
Yan Li   +8 more
doaj   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

open access: yes, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie   +13 more
core   +1 more source

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +2 more sources

A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells [PDF]

open access: yes, 2007
MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase tumorigenesis in mismatch repair ...
Bader, S A   +6 more
core   +1 more source

Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents

open access: yesFrontiers in Oncology, 2022
Recently, biallelic germline variants of the DNA glycosylase genes MUTYH and NTHL1 were linked to polyposis susceptibility. Significant fractions remain without a molecular explanation, warranting searches for underlying causes.
Alisa Petriina Olkinuora   +23 more
doaj   +1 more source

MBD4 Interacts with and Recruits USP7 to heterochromatic foci [PDF]

open access: yes, 2014
MBD4 is the only methyl-CpG binding protein that possesses a C-terminal glycosylase domain. It has been associated with a number of nuclear pathways including DNA repair, DNA damage response, the initiation of apoptosis, transcriptional repression, and ...
Richard R. Meehan   +9 more
core   +1 more source

Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision

open access: yesScientific Reports, 2017
Thymine DNA glycosylase (TDG) and Nei-like 1 (NEIL1) have both been implicated in the base excision repair step of active DNA demethylation. The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (
Anton Slyvka   +2 more
doaj   +1 more source

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