Results 91 to 100 of about 44,346 (216)

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases [PDF]

DNA Repair, 2009
Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three-dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg proteins recognizing formamidopyrimidines, 8-oxoguanine (8-oxoG) and its oxidation products ...
Scott D, Kathe, Ramiro, Barrantes-Reynolds, Pawel, Jaruga, Michael R, Newton, Cynthia J, Burrows, Viswanath, Bandaru, Miral, Dizdaroglu, Jeffrey P, Bond, Susan S, Wallace   +8 more
openaire   +2 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]

, 2015
Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei, Gao, Lei, Kim, Yun Ju, Li, Shaofang, Li, Shengben, Liu, Lin, Zhao, Yuanyuan   +6 more
core   +2 more sources

Structure of Formamidopyrimidine-DNA Glycosylase Covalently Complexed to DNA [PDF]

Journal of Biological Chemistry, 2002
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. The Schiff base intermediate formed during this reaction between Escherichia coli Fpg and DNA was trapped by reduction with sodium borohydride, and the structure of the resulting covalently cross-linked complex was determined at a 2.1-A ...
Rotem, Gilboa, Dmitry O, Zharkov, Gali, Golan, Andrea S, Fernandes, Sue Ellen, Gerchman, Eileen, Matz, Jadwiga H, Kycia, Arthur P, Grollman, Gil, Shoham   +8 more
openaire   +2 more sources

Predators of the two paropsine leaf beetles Paropsisterna cloelia and Paropsis charybdis in eucalypt plantations in Marlborough, New Zealand Prädatoren der zwei Blattkäfer Paropsisterna cloelia and Paropsis charybdis in Eukalyptusplantagen in Marlborough, Neuseeland

Agricultural and Forest Entomology, EarlyView.
Coccinellidae (Coleoptera), Miridae (Hemiptera), Hemerobiidae (Neuroptera), Pentatomidae (Hemiptera), Anystidae (Acari), Erythraeidae (Acari) and spiders (Araneidae, Oxyopidae and Salticidae) fed on the invasive paropsine leaf beetles in Marlborough, New Zealand.
Carolin Weser, Manpreet K. Dhami, Elena Moltchanova, Ana Podolyan, Toni M. Withers, Stephen M. Pawson   +5 more
wiley   +1 more source

Lesion Recognition and Cleavage of Damage-Containing Quadruplexes and Bulged Structures by DNA Glycosylases

Frontiers in Cell and Developmental Biology, 2020
Human telomeres as well as more than 40% of human genes near the promoter regions have been found to contain the sequence that may form a G-quadruplex structure.
Alexandra A. Kuznetsova, Olga S. Fedorova, Olga S. Fedorova, Nikita A. Kuznetsov, Nikita A. Kuznetsov   +4 more
doaj   +1 more source

XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. [PDF]

, 2010
PurposeEpidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage.
Chen, Pei-Liang, Cheng, Ya-Wen, Koeh, Hank, Lee, Huei, Liu, Yu-Ling, Tsai, Yi-Yu, Yeh, Kun-Tu   +6 more
core   +1 more source

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG) [PDF]

, 2009
The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N[superscript 6]-ethenoadenine (εA).
Aas P. A., Abner C. W., Adhikari S., Berti P. J., Bjelland S., Chakravarti D., Delaney J. C., Delaney J. C., Dianov G., Dosanjh M. K., Eftedal I., el Ghissassi F., Elder R. H., Engelward B. P., Falnes P. O., Falnes P. O., Falnes P. O., Frick L. E., Friedberg E. C., Gallagher P. E., Goodenough A. K., Guengerich F. P., Guengerich F. P., Guengerich F. P., Guliaev A. B., Hang B., Haushalter K. A., Hitchcock T. M., Koivisto P., Kusmierek J. T., Kusmierek J. T., Lau A. Y., Lau A. Y., Leonard N. J., Ludlum D. B., Miao F., Mishina Y., Nilsen H., Ougland R., O’Brien P. J., O’Brien P. J., O’Connor T. R., O’Connor T. R., O’Neill R. J., Pearl L. H., Pendlebury A., Ringvoll J., Roy R., Samson L., Saparbaev M., Saparbaev M., Saparbaev M., Singer B., Trewick S. C., Wang H., Westbye M. P., Wuenschell G. E., Wyatt M. D.   +57 more
core   +1 more source

Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation [PDF]

Journal of Biological Chemistry, 2016
In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases and excision of these two oxidized bases by thymine DNA glycosylase (TDG). Although TDG is essential for active demethylation in embryonic stem cells and induced pluripotent stem cells, it is ...
Jian-Huang, Xue, Gui-Fang, Xu, Tian-Peng, Gu, Guo-Dong, Chen, Bin-Bin, Han, Zhi-Mei, Xu, Magnar, Bjørås, Hans E, Krokan, Guo-Liang, Xu, Ya-Rui, Du   +9 more
openaire   +2 more sources

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source