Results 41 to 50 of about 2,011,431 (260)
Defects Can Increase the Melting Temperature of DNA-Nanoparticle Assemblies [PDF]
J. Phys. Chem. B, 110 (2006) 16393-16396, 2007 DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable detection technology.
arxiv +1 more source
A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage
Angewandte Chemie, EarlyView.This work advances methodology by addressing challenges in mimicking the complex in vivo spatial relationships of histone acetylation and DNA damage. The combination of an abiotic/enzymatic hybrid catalyst system (ABEHCS) and the plug‐and‐play method has constituted a versatile platform to construct nucleosome arrays with precise histone acetylation ...
Ziyun Liu +6 more
wiley +2 more sources
FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC. [PDF]
PLoS Genetics, 2016 FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair.
John Lalith Charles Richard +11 more
doaj +1 more source
Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana
BMC Plant Biology, 2022 Background MicroRNAs (miRNAs) and other epigenetic modifications play fundamental roles in all eukaryotic biological processes. DNA damage repair is a key process for maintaining the genomic integrity of different organisms exposed to diverse stresses ...
Juan Du +8 more
doaj +1 more source
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).
ACS Chemical Biology, 2015 The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination.
N. Donley +5 more
semanticscholar +1 more source
Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
Molecular Cancer, 2004 Background Uracil DNA glycosylase (UDG) plays a major role in repair of uracil formed due to deamination of cytosine. UDG in human cells is present in both the nucleus and mitochondrial compartments.
Singh Keshav K, Kachhap Sushant
doaj +1 more source
Elongation/Compaction of Giant DNA Caused by Depletion Interaction with a Flexible Polymer [PDF]
, 2005 Structural changes in giant DNA induced by the addition of the flexible polymer PEG were examined by the method of single-DNA observation. In dilute DNA conditions, individual DNA assumes a compact state via a discrete coil-globule transition, whereas in concentrated solution, DNA molecules exhibit an extended conformation via macroscopic phase ...
arxiv +1 more source
Advanced Sensor Research, EarlyView.A novel approach for direct sensing of viral RNA is proposed, allowing PCR‐free detection of viral RNA from genomic material, and variants screening by discrimination of polymorphic amplicons. The device is a cost‐effective, user‐friendly platform suitable for both mass screening kits and as a laboratory tool for an optimized management of resources ...
Stefano Lai +4 more
wiley +1 more source
Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging
Nucleic Acids Research, 2015 The ability of DNA glycosylases to rapidly and efficiently detect lesions among a vast excess of nondamaged DNA bases is vitally important in base excision repair (BER). Here, we use single molecule imaging by atomic force microscopy (AFM) supported by a
Claudia N. Buechner +3 more
semanticscholar +1 more source
Crystal structure of mimivirus uracil-DNA glycosylase. [PDF]
PLoS ONE, 2017 Cytosine deamination induced by stresses or enzymatic catalysis converts deoxycytidine into deoxyuridine, thereby introducing a G to A mutation after DNA replication.
Eunju Kwon +3 more
doaj +1 more source