Results 51 to 60 of about 2,011,431 (260)

The Diminution of R‐Loops Generated by LncRNA DSP‐AS1 Inhibits DSP Gene Transcription to Impede the Re‐Epithelialization During Diabetic Wound Healing

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Down‐regulated LncRNA DSP‐AS1, the diminution of R‐loop formation, reduced Ten‐eleven translocation 3 (TET3) occupancy, inhibited DNA demethylation at the DSP promoter, and disrupted re‐epithelialization process proceed sequentially during delayed diabetic wound healing.
Chen Yang, Hong Lian, Hengli Luo, Chenlin Song, Jianghong Lin, Zhuoxian Liang, Yulin Yang, Xiaosi Hong, Shaohua Li, Yanbo Chen, Liangyan Wu, Li Yan, Sifan Chen, Meng Ren   +13 more
wiley   +1 more source

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

International Journal of Molecular Sciences, 2014
Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure.
Xueqing Ba, L. Aguilera-Aguirre, Qura-Tul-Ain Rashid, A. Bácsi, Z. Radák, S. Sur, K. Hosoki, M. Hegde, I. Boldogh   +8 more
semanticscholar   +1 more source

Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty, Saravanabhavan Thangavel   +1 more
wiley   +1 more source

Bacillus Calmette-Guerin Increases Base Excision Repair in Bladder Cancer Cells

Journal of Urological Surgery, 2021
Objective:Most patients with non-muscle-invasive bladder cancer (NMIBC) do not respond to intravesical Bacillus Calmette-Guerin (BCG) immunotherapy and have high risk of NMIBC recurrence and progression.
Selçuk Keskin, Berna Somuncu, Meltem Müftüoğlu   +2 more
doaj   +1 more source

Simulating 3-symbol Turing machines with SIMD||DNA [PDF]

arXiv, 2021
SIMD||DNA is a model of DNA strand displacement allowing parallel in-memory computation on DNA storage. We show how to simulate an arbitrary 3-symbol space-bounded Turing machine with a SIMD||DNA program, giving a more direct and efficient route to general-purpose information manipulation on DNA storage than the Rule 110 simulation of [Wang, Chalk ...
arxiv  

Sequence Context‐Agnostic TadA‐Derived Cytosine Base Editors for Genome‐Wide Editing in Zebrafish

Advanced Science, Volume 12, Issue 14, April 10, 2025.
zTadA‐CBEs, developed by introducing key mutations into TadA8e, enable efficient and precise sequence context‐agnostic cytosine base editing. Specifically, zTadA‐BE4max and zTadA‐BEmv provide complementary editing windows, while zTadA‐SpRY‐BE4max offers PAM‐flexible editing.
Shaohui Zheng, Yang Liu, Xinxin Xia, Jiawang Xiao, Hui Ma, Xuanyao Yuan, Yan Zhang, Zixi Chen, Guangcong Peng, Wenyuan Li, Ji‐Feng Fei, Yanmei Liu   +11 more
wiley   +1 more source

Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate*

Journal of Biological Chemistry, 2014
Background: E3 ubiquitin ligases facilitate destruction of other proteins. Results: In frog egg extract, the DNA repair factor thymine DNA glycosylase (TDG) was destroyed during DNA replication and repair, dependent on the E3 ubiquitin ligase CRL4Cdt2 ...
Tamara J. Slenn, Benjamin L. Morris, Courtney G. Havens, R. Freeman, Tatsuro S. Takahashi, J. Walter   +5 more
semanticscholar   +1 more source

HUWE1‐Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury

Advanced Science, Volume 12, Issue 13, April 3, 2025.
MutY homolog (MUTYH) protein levels are significantly decreased in the kidneys of acute kidney injury (AKI) patients. The upregulation of the E3 ligase HUWE1 mediates the degradation of MUTYH in renal tubular epithelial cells, exacerbating DNA damage in both the nucleus and mitochondria, thereby promoting AKI. Targeting the HUWE1/MUTYH pathway may be a
Yunwen Yang, Peipei Wang, Kaiqian Zhou, Wen Zhang, Suwen Liu, Jing Ouyang, Mi Bai, Guixia Ding, Songming Huang, Zhanjun Jia, Aihua Zhang   +10 more
wiley   +1 more source

Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition

Nucleic Acids Research, 2014
Formamidopyrimidine-DNA glycosylase (Fpg) excises 8-oxoguanine (oxoG) from DNA but ignores normal guanine. We combined molecular dynamics simulation and stopped-flow kinetics with fluorescence detection to track the events in the recognition of oxoG by ...
N. Kuznetsov, Christina Bergonzo, Arthur J. Campbell, Haoquan Li, G. V. Mechetin, C. R. de los Santos, A. Grollman, O. Fedorova, D. Zharkov, Carlos Simmerling   +9 more
semanticscholar   +1 more source

Self-assembling DNA-caged particles: nanoblocks for hierarchical self-assembly [PDF]

, 2008
DNA is an ideal candidate to organize matter on the nanoscale, primarily due to the specificity and complexity of DNA based interactions. Recent advances in this direction include the self-assembly of colloidal crystals using DNA grafted particles. In this article we theoretically study the self-assembly of DNA-caged particles. These nanoblocks combine
arxiv   +1 more source