Results 21 to 30 of about 20,880 (290)
Nature Communications, 2021 Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products.
Elwood A. Mullins +4 more
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A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases. [PDF]
PLoS ONE, 2015 DNA glycosylases are important repair enzymes that eliminate a diverse array of aberrant nucleobases from the genomes of all organisms. Individual bacterial species often contain multiple paralogs of a particular glycosylase, yet the molecular and ...
Elwood A Mullins +3 more
doaj +1 more source
Inhibition of DNA glycosylases via small molecule purine analogs. [PDF]
PLoS One, 2013 Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed.
Jacobs AC +9 more
europepmc +2 more sources
Open Biology, 2021 Base excision repair is one of the important DNA repair mechanisms in cells. The fundamental role in this complex process is played by DNA glycosylases.
Anna Ligasová +4 more
doaj +1 more source
Nature Communications, 2021 Active DNA demethylation is required for sexual reproduction in plants, but the underlying mechanisms are unknown. Here, the authors show that the DNA glycosylases DEMETER and REPRESSOR OF SILENCING 1 enable the DNA demethylation-dependent activation of ...
Souraya Khouider +7 more
doaj +1 more source
Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
Communications Biology, 2021 Ahmadi et al. use a single-molecule tracking method to describe the DNA scanning mode of AlkD, a HEAT-like repeat DNA glycosylase. They show that, contrary to other glycosylases that use a base-flipping mechanism, AlkD scans the DNA without forming a ...
Arash Ahmadi +10 more
doaj +1 more source
IMG-DNA: Approximate DNA Storage for Images [PDF]
, 2021 Deoxyribonucleic Acid (DNA) as a storage medium with high density and long-term preservation properties can satisfy the requirement of archival storage for rapidly increased digital volume. The read and write processes of DNA storage are error-prone. Images widely used in social media have the properties of fault tolerance which are well fitted to the ...
arxiv +1 more source
Strandwise translocation of a DNA glycosylase on undamaged DNA [PDF]
Proceedings of the National Academy of Sciences, 2012 Base excision repair of genotoxic nucleobase lesions in the genome is critically dependent upon the ability of DNA glycosylases to locate rare sites of damage embedded in a vast excess of undamaged DNA, using only thermal energy to fuel the search process.
Marie C. Spong +7 more
openaire +3 more sources
Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase [PDF]
, 2009 hSMUG1 (human single-stranded selective monofunctional uracil-DNA glyscosylase) is one of three glycosylases encoded within a small region of human chromosome 12. Those three glycosylases, UNG (uracil-DNA glycosylase), TDG (thymine-DNA glyscosylase), and
Agus Darwanto +63 more
core +3 more sources
The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells. [PDF]
PLoS ONE, 2012 During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1.
Anna J Ucher +4 more
doaj +1 more source