Results 41 to 50 of about 533,967 (266)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler

Life Science Alliance, 2023
Biochemical data suggest that the SAM-key domain of the budding yeast remodeler Fun30 is required for its nucleosome remodeling activity by regulating the catalytic ATPase.
Leonhard A Karl, Lorenzo Galanti, Susanne CS Bantele, Felix Metzner, Barbara Šafarić, Lional Rajappa, Benjamin Foster, Vanessa Borges Pires, Priyanka Bansal, Erika Chacin, Jerôme Basquin, Karl E Duderstadt, Christoph F Kurat, Till Bartke, Karl-Peter Hopfner, Boris Pfander   +15 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Nanopore Integrated Nanogaps for DNA Detection [PDF]

Nano Letters, 2013
A high-throughput fabrication of sub-10 nm nanogap electrodes combined with solid-state nanopores is described. These devices should allow concomitant tunneling and ionic current detection of translocating DNA molecules. We report the optimal fabrication parameters in terms of dose, resist thickness, and gap shape that allow easy reproduction of the ...
Axel, Fanget, Traversi, Floriano, Khlybov, Sergey, Granjon, Pierre, Magrez, Arnaud, Fórró, Lászlo, Radenovic, Aleksandra   +6 more
openaire   +4 more sources

Exploring potent miRNA combinations for detecting early-stage breast cancer

Molecular Therapy: Nucleic Acids
Breast cancer (BC) is the most prevalent cancer among women globally. Identifying BC at its early stage is of significant importance; however, due to the limited resolution and the accompanying adverse events of the current detection methods, including ...
Barbara N. Borsos, Zoltán G. Páhi, Tibor Pankotai   +2 more
doaj   +1 more source

Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity

Life Science Alliance, 2021
hnRNP E1 binds polycytosine tracts of DNA and monitors genome integrity. Heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) is a tumor suppressor protein that binds site- and structure-specifically to RNA sequences to regulate mRNA stability ...
Bidyut K Mohanty, Joseph AQ Karam, Breege V Howley, Annamarie C Dalton, Simon Grelet, Toros Dincman, William S Streitfeld, Je-Hyun Yoon, Lata Balakrishnan, Walter J Chazin, David T Long, Philip H Howe   +11 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors

Scientific Reports
Breast cancer is a prevalent and significant cause of mortality in women, and manifests as six molecular subtypes. Its further histologic classification into non-invasive ductal or lobular carcinoma (DCIS) and invasive carcinoma (ILC or IDC) underscores ...
Vasiliki Pantazi, Vanda Miklós, Paul Smith, Orsolya Oláh-Németh, Gabriella Pankotai-Bodó, Divya Teja Dondapati, Ferhan Ayaydin, Vincenzo D’Angiolella, Tibor Pankotai   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source