Results 21 to 30 of about 2,573,553 (254)
Targeting the DNA double strand break repair machinery in prostate cancer [PDF]
Regardless of the achievable remissions with first line hormone therapy in patients with prostate cancer (CaP), the disease escapes the hormone dependent stage to a more aggressive status where chemotherapy is the only effective treatment and no ...
Fadhel S. Shaheen +34 more
core +1 more source
Sperm quality and DNA integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons [PDF]
Objectives: The objective of this study was to assess sperm quality and deoxyribonucleic acid (DNA) integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) as compared to control subjects.
Jeng, Hueiwang Anna +18 more
core +2 more sources
A small RNA response at DNA ends in Drosophila [PDF]
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Förstemann, Klaus +2 more
core +1 more source
Single Cell Analysis of Human RAD18-Dependent DNA Post-Replication Repair by Alkaline Bromodeoxyuridine Comet Assay [PDF]
Damage to DNA can block replication progression resulting in gaps in the newly synthesized DNA. Cells utilize a number of post-replication repair (PRR) mechanisms such as the RAD18 controlled translesion synthesis or template switching to overcome the ...
Himabindu Gali +14 more
core +2 more sources
Integrative functional and molecular characterization of Bali bull semen and its relationship with reproductive performance [PDF]
Background and Aim: Bali cattle (Bos javanicus) are an important indigenous genetic resource in Indonesia, characterized by high adaptability and reproductive efficiency. However, conventional semen evaluation based on motility and morphology often fails
Hendri Hendri +10 more
doaj +1 more source
EFFECT OF ANTIOXIDANT AND ITS CONCENTRATION ON THE SPERM QUALITY OF WALKING CATFISH Clarias batrachus POST CRYOPRESERVATION [PDF]
The walking catfish Clarias batrachus is popular and affordable in Southeast Asian countries. The development of breeding technology for this species is ongoing, with sperm cryopreservation being a key aspect of study that supports its breeding program ...
Muchlisin Abidin +8 more
doaj +1 more source
Xeroderma pigmentosum (XP) is a rare genetic condition in which exposure to sunlight leads to a high tumor incidence due to defective DNA repair machinery.
Ligia Pereira Castro +16 more
doaj +1 more source
The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler that acts in transcription, replication, and genome stability. It is required for resistance against genotoxic agents and is involved in the repair of DNA double-strand ...
Claudio A. Lademann +3 more
doaj +1 more source
Deep learning-based selection of human sperm with high DNA integrity
Despite the importance of sperm DNA to human reproduction, currently no method exists to assess individual sperm DNA quality prior to clinical selection.
Sanner, Scott +29 more
core +1 more source

