Results 11 to 20 of about 533,967 (266)
Cold Spring Harbor Perspectives in Medicine, 2012 Retroviruses are distinguished from other viruses by two characteristic steps in the viral replication cycle. The first is reverse transcription, which results in the production of a double-stranded DNA copy of the viral RNA genome, and the second is integration, which results in covalent attachment of the DNA copy to host cell DNA.
Robert, Craigie, Frederic D, Bushman
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Retroviral DNA Integration [PDF]
Microbiology and Molecular Biology Reviews, 1999 SUMMARY DNA integration is a unique enzymatic process shared by all retroviruses and retrotransposons. During integration, double-stranded linear viral DNA is inserted into the host genome in a process catalyzed by the virus-encoded integrase (IN).
P, Hindmarsh, J, Leis
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Retroviral DNA integration and the DNA damage response [PDF]
Cell Death & Differentiation, 2005 Retroviral DNA integration creates a discontinuity in the host cell chromatin and repair of this damage is required to complete the integration process. As integration and repair are essential for both viral replication and cell survival, it is possible that specific interactions with the host DNA repair systems might provide new cellular targets for ...
A M, Skalka, R A, Katz
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Loops are Geometric Catalysts for DNA Integration
Nucleic Acids Research, 2023 The insertion of HIV and other DNA elements within genomes underpins both genetic diversity and disease when unregulated. Most of these insertions are not random and occupy specific positions within the genome but the physical mechanisms underlying the integration site selection are poorly understood.
Cleis Battaglia, Davide Michieletto
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Chemical Reviews, 2016 The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among retroviruses and LTR-retrotransposons. Retroviral integration proceeds via two integrase activities: 3'-processing of the viral DNA
Lesbats, Paul +2 more
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Plant DNA Repair and Agrobacterium T−DNA Integration [PDF]
International Journal of Molecular Sciences, 2021 Agrobacterium species transfer DNA (T−DNA) to plant cells where it may integrate into plant chromosomes. The process of integration is thought to involve invasion and ligation of T-DNA, or its copying, into nicks or breaks in the host genome. Integrated T−DNA often contains, at its junctions with plant DNA, deletions of T−DNA or plant DNA, filler DNA ...
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Reassessing the interpretation of oxidation–reduction potential in male infertility
Reproduction and Fertility, 2022 Male Infertility Oxidative System (MiOXSYS) has been proposed as a rapid and promising technology for the evaluation of sperm oxidative stress. In this case–control study, 134 men with normal sperm parameters (NSP) and 574 men with abnormal sperm ...
Fabien Joao +7 more
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eLife, 2017 DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct ligation-based mechanisms. Pathway choice is made at the level of DNA end resection, a nucleolytic processing step, which primes DSBs for repair by recombination ...
Susanne CS Bantele +4 more
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Moving DNA around: DNA transposition and retroviral integration [PDF]
Current Opinion in Structural Biology, 2011 Mobile DNA elements are found in all kingdoms of life, and they employ numerous mechanisms to move within and between genomes. Here we review recent structural advances in understanding two very different families of DNA transposases and retroviral integrases: the DDE and Y1 groups.
Sherwin P, Montaño, Phoebe A, Rice
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Quantitative sensing and signalling of single-stranded DNA during the DNA damage response
Nature Communications, 2019 DNA damage triggers checkpoint signalling mechanisms. Here the authors reveal differential phosphorylation of targets of the Mec1-Ddc2 checkpoint kinase by analyzing the effect of quantitatively different ssDNA signals.
Susanne C. S. Bantele +2 more
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