Results 51 to 60 of about 817,746 (315)

Electronic Spectroscopy of Isolated DNA Polyanions [PDF]

Faraday Discussions, 2018
We address whether action spectroscopy could be used to investigate structural changes in gas-phase biomolecule ( e.g. nucleic acid) ions, owing to changes in the environments of their chromophores, while taking advantage of the additional spectrometric separation of complex mixtures.
Steven Daly, Massimiliano Porrini, Frédéric Rosu, Valérie Gabelica   +3 more
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The terminal redundant regions of bacteriophage T7 DNA: their necessity for phage production studied by the infectivity of T7 DNA after modification by various exonucleases

, 1978
Dreiseikelmann B, Wackernagel W. The terminal redundant regions of bacteriophage T7 DNA: their necessity for phage production studied by the infectivity of T7 DNA after modification by various exonucleases. Molecular and General Genetics. 1978;159(3):321-
Dreiseikelmann, Brigitte, Wackernagel, Wilfried   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Wolbachia and DNA barcoding insects: patterns, potential and problems

, 2012
Wolbachia is a genus of bacterial endosymbionts that impacts the breeding systems of their hosts. Wolbachia can confuse the patterns of mitochondrial variation, including DNA barcodes, because it influences the pathways through which mitochondria are ...
Janzen, D H, Mark R. Shaw (167095), Packer , L, Julie K. Stahlhut (167104), Claudia Bertrand (167052), Dirk Steinke, Xin Zhou, Crosby, K, Yanwei Li (167076), Quicke Donald, Quicke, D, Eveleigh Eldon S., Monty Wood, Steinke Dirk, Stahlhut, J K, Katharine Hind, Fernandez-Triana, J, Shaw, Mark R, Winnie Hallwachs, Hind Katharine, Ratnasingham, S, Da-Wei Huang, Yanwei, L, Katharine Hind (167065), Julie K Stahlhut, Bertrand, C, Eldon S. Eveleigh (167054), Hind, K, Daniel H Janzen, Jason Gibbs (167056), Brian L Fisher, Fisher, B L, Cory Sheffield, Mehrdad Hajibabaei, James Whitfield (167108), Monty Wood (167110), Miller Scott E., Josephine Rodriguez, Brian L. Fisher (47870), Sujeevan Ratnasingham (167085), Kate Crosby, Donald Quicke, Wood Monty, Janda Milan, Jan Hrcek (167068), Huang Da-Wei, Ratnasingham Sujeevan, Gibbs, J, Hallwachs Winnie, Huang, D W, Rodriguez, J J, Kate Crosby (167053), Laurence Packer, Scott E. Miller (167079), Eldon S Eveleigh, Smith M. Alex, James Whitfield, Zhou, X, Scott E Miller, Zhou Xin, Rodolphe Rougerie (134289), Yanwei Li, Janda, M, Crosby Kate, Hrcek, J, Cory Sheffield (167100), Whitfield, J B, Jason Gibbs, Wood, M, M Alex Smith, Rodolphe Rougerie, Smith, M A, Sheffield Cory, Rougerie Rodolphe, Hallwachs, W, Donald Quicke (167083), Fisher Brian L., Sheffield, C, Jan Hrcek, Rodriguez Josephine, Mehrdad Hajibabaei (76205), Packer Laurence, Stahlhut Julie K., Whitfield James, M. Alex Smith (47871), Winnie Hallwachs (167061), Wood , M, Milan Janda, Bertrand Claudia, Gibbs Jason, Da-Wei Huang (102802), Miller, S E, Dirk Steinke (15543), Laurence Packer (167080), Mark R Shaw, Li Yanwei, Packer, L, Hajibabaei Mehrdad, Rougerie, R, Claudia Bertrand, Hrcek Jan, Sujeevan Ratnasingham, Daniel H. Janzen (167074), Fernandez-Triana Jose, Steinke, D, Jose Fernandez-Triana (167055), Milan Janda (167072), Josephine Rodriguez (167090), Hajibabaei, M, Xin Zhou (54275), Jose Fernandez-Triana, Janzen Daniel H., Shaw Mark R., Eveleigh, E S, Janda , M   +114 more
core   +1 more source

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos [PDF]

, 2015
During cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Blow, J. Julian; id_orcid, Karim Labib, Craig, Gillian, Remi Sonneville, Labib, Karim, Sonneville, Remi, Gillian Craig, Anton Gartner, J. Julian Blow, Blow, J. Julian, Labib, Karim; id_orcid, Gartner, Anton   +11 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source