Results 171 to 180 of about 9,982 (202)

Architecture and regulation of nanoscale chromatin domains. [PDF]

Nat Commun
Vinayak V, Lakadamyali M, Shenoy VB.
europepmc   +1 more source

A modular framework for automated segmentation and analysis of AFM imaging of chromatin organization. [PDF]

Nucleic Acids Res
Sørensen EW, Pangeni S, Merino Urteaga R, Murray PJ, Rudnizky S, Liao TW, Rashid F, Hwang J, Yamadi M, Feng XA, Zähringer J, Gu S, Davidson IF, Caccianini L, Osorio-Valeriano M, Farnung L, Vos SM, Peters JM, Berger J, Wu C, Hatzakis NS, Kirkegaard JB, Ha T.   +22 more
europepmc   +1 more source

Phase separation as an emerging regulatory framework in antibody class switching and genome stability. [PDF]

Front Immunol
Refaat AM, Shimizu H, Yasuhara T.
europepmc   +1 more source

Spatially correlated fluctuations govern relative chromatin motion

Harju J, Ubertini M, Kailash D, Chen P, Ronceray P, Giorgetti L, Gregor T, Brückner DB.   +7 more
europepmc   +1 more source

Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling

Singh AK, Altamirano-Pacheco L, Taing L, Dubois A, Navarro P.   +4 more
europepmc   +1 more source

Loop extrusion as a mechanism for formation of DNA damage repair foci

Nature, 2021
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the formation of DNA-damage response foci1. It is unclear how these
Raphaël Mourad, James Haber, Gaëlle Legube   +2 more
exaly   +8 more sources

DNA loop extrusion by human cohesin

Science, 2019
Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
GORDANA Wütz, Jan-Michaél Peters, Iain Davidson   +2 more
exaly   +3 more sources

Cohesin supercoils DNA during loop extrusion

Cell Reports
Cohesin extrudes genomic DNA into loops that promote chromatin assembly, gene regulation, and gene recombination. Loop extrusion depends on large-scale conformational changes in cohesin, but how these translocate DNA is poorly understood. Here, we provide evidence that cohesin negatively supercoils DNA during loop extrusion.
Jan-Michaél Peters
exaly   +4 more sources

CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion

Nature, 2023
AbstractIn eukaryotes, genomic DNA is extruded into loops by cohesin1. By restraining this process, the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating domains (TADs)2,3 that have important roles in gene regulation and recombination during development and disease1,4–7.
Cees Dekker, Roman Barth, Richard Janissen   +2 more
exaly   +5 more sources

Current working models of SMC-driven DNA-loop extrusion

Biochemical Society Transactions, 2023
Structural maintenance of chromosome (SMC) proteins play a key roles in the chromosome organization by condensing two meters of DNA into cell-sized structures considered as the SMC protein extrudes DNA loop. Recent sequencing-based high-throughput chromosome conformation capture technique (Hi-C) and single-molecule experiments have provided direct ...
Je-Kyung Ryu, Ryu Je-Kyung
exaly   +3 more sources