Results 181 to 190 of about 2,102,008 (248)

Characterization of induced cohesin loop extrusion trajectories in living cells

Cohesin (SMC1–SMC3–RAD21) constantly extrudes DNA loops to organize chromosomes into structural domains, pausing and anchoring at specific DNA-bound CTCF molecules.
Vaandrager, Iwan, de Wit, Elzo, Allahyar, Amin, CMM Groep De Ridder, de Laat, Wouter, Han, Ruiqi, Genetica, Zhang, Kexin, Krijger, Peter H.L., Magnitov, Mikhail, Verstegen, Marjon J.A.M., Genetica Sectie Research, Huang, Yike, Robers, Michelle J., Hubrecht Institute with UMC, Cancer   +15 more
core  

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes. [PDF]

Protein Sci
Maytin AK, Gilbert BR, Luthey-Schulten Z.   +2 more
europepmc   +1 more source

Hierarchical Assembly as a Design Principle: Structure–Property Relationships Linking Biological Architectures to Functional Aggregate Materials

Aggregate, Volume 7, Issue 9, September 2026.
Biological function arises from aggregates rather than from molecules. Comparing biomimetic systems on a common basis reveals three transferable design rules governing hierarchical assembly, interfacial gradients, and stimulus‐coupled anisotropy, and identifies self‐healing and single‐step multiscale integration as properties that do not transfer to ...
Nafeesa Sarfraz, Sadaf Bibi, Muhammad Ibrar Ahmed, Jawad Hussain, Shahid Iqbal, Imran Mahmood Khan, Ajayan Vinu, Ibrahim Khan   +7 more
wiley   +1 more source

The eukaryotic homology search complex distorts donor DNA structure to probe for homology. [PDF]

Genes Dev
Woodhouse MV, Hu J, Wu M, Qian J, Inman JT, Wang MD, Crickard JB.   +6 more
europepmc   +1 more source

The Role of Arp2/3 in End‐Resection During DNA Double‐Strand Break Repair

BioEssays, Volume 48, Issue 9, September 2026.
Arp2/3 has an evolutionarily conserved role in promoting 5’ to 3’ resection of DSBs, RAD51 filament formation, maintenance of the DNA damage checkpoint, increased mobility of DSBs, and relocation of damage in heterochromatin regions to the nuclear periphery.
Felix Y. Zhou, James E. Haber
wiley   +1 more source

Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to <i>Sox2</i> looping with its distal enhancer. [PDF]

Genes Dev
Martinovic M, Flach KD, de Kort MAC, Maresca M, Teunissen H, Liu NQ, Lenstra TL, de Wit E.   +7 more
europepmc   +1 more source

Distinct and compensatory roles of STAG1 and STAG2 in post-mitotic genome refolding. [PDF]

Nat Commun
Wang M, Zhang Y, Shan F, Pei C, Liu F, Xia S, Shu L, Li B, Jing D, Weng Y, Zhao H, Lin Y, Yu Y, Wang B, Zhang H.   +14 more
europepmc   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, Volume 4, Issue 3, September 2026.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Context-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2. [PDF]

Nat Commun
Chang F, Berke-Reynolds B, Yu X, Bush EL, Colón-Rosado JA, Sun L, Wang J, Zhang Y.   +7 more
europepmc   +1 more source

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source