Results 251 to 260 of about 2,768,548 (336)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Additional file 25: of Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies

, 2017
Maria Needhamsen, Ewoud Ewing, Harald Lund, David Gómez-Cabrero, Robert A. Harris, Lara Kular, Maja Jagodic   +6 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

DNA methylation predicts adverse outcomes of coronary artery disease. [PDF]

Nat Commun
Qin M, Tian X, Wu Q, Zhu Q, Yu M, Fang X, Chen X, Liu C, Zhang B, Li H, Wang X, Pan C, Zhong S.   +12 more
europepmc   +1 more source

Additional file 12: of Blood lipids influence DNA methylation in circulating cells

, 2016
Koen F. Dekkers, Maarten van Iterson, Roderick C. Slieker, Matthijs Moed, Marc Jan Bonder, Michiel van Galen, Hailiang Mei, Daria V. Zhernakova, Leonard van den Berg, Joris Deelen, Jenny van Dongen, Alan B. Zonderman, Albert Hofman, Jouke Hottenga, Carla Kallen, Casper G. Schalkwijk, Coen D.A. Stehouwer, Ettje F. Tigchelaar, AndrĂŠ Uitterlinden, Gonneke Willemsen, Alexandra Zhernakova, Lude Franke, Peter A.C. ’t Hoen, Rick Jansen, Joyce B. J. van Meurs, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Erik W. van Zwet, P. Eline Slagboom, J. Wouter Jukema, Bastiaan T. Heijmans   +33 more
openalex   +2 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Bacterial lipopolysaccharide alters DNA methylation in colorectal cancer cells. [PDF]

Clin Epigenetics
Permain J, Sulit A, Eglinton T, Purcell R.   +3 more
europepmc   +1 more source

MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease

David Lukacsovich, Deirdre O’Shea, Hanchen Huang, Wei Zhang, Juan I. Young, X. Steven Chen, Sven‐Thorsten Dietrich, Brian W. Kunkle, Eden R. Martin, Lily Wang   +9 more
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Effect of Diet before Bariatric Surgery on Ghrelin Level through DNA Methylation

Duygu Güçlü, Nilgün Işıksaçan, Hakan Seyit, Asuman Gedikbaşı, Mehmet Karabulut, İrem Erdil, Tamay Seda Taşçı, Mustafa Yaman   +7 more
openalex   +1 more source