Results 21 to 30 of about 2,392,207 (383)
Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta. [PDF]
PLoS ONE, 2014 A small number of recent reports have suggested that altered placental DNA methylation may be associated with early onset preeclampsia. It is important that further studies be undertaken to confirm and develop these findings.
Tianjiao Chu +6 more
doaj +1 more source
DNA methylation in fibrosis [PDF]
European Journal of Cell Biology, 2016 Fibrosis is characterised by an exuberant wound healing response and the major cell type responsible is the myofibroblast. The myofibroblast is typified by excessive ECM production and contractile activity and is demarcated by alpha-smooth muscle actin expression. What has recently come to light is that the activation of the fibroblast to myofibroblast
Steven O'Reilly, Christopher G. Dowson
openaire +3 more sources
DNA methylation age of human tissues and cell types
Genome Biology, 2013 It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure.
S. Horvath
semanticscholar +1 more source
Predictors and consequences of global DNA methylation in cord blood and at three years. [PDF]
PLoS ONE, 2013 DNA methylation changes have been implicated in many common chronic diseases leading to the hypothesis that environmental and age-related DNA methylation changes within individuals are involved in disease etiology.
Julie B Herbstman +8 more
doaj +1 more source
DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma
Frontiers in Cell and Developmental Biology, 2022 Growing evidence links DNA methylation to tumor immunity. The impact of DNA methylation (5 mC) on the microenvironment surrounding tumors and immunotherapy remains to be clarified. Through clustering gene expression of 20 DNA methylation regulators, this
Xinyu Yu +8 more
doaj +1 more source
DNA Methylation and Differentiation [PDF]
Environmental Health Perspectives, 1989 The methylation of specific cytosine residues in DNA has been implicated in regulating gene expression and facilitating functional specialization of cellular phenotypes. Generally, the demethylation of certain CpG sites correlates with transcriptional activation of genes.
Lesley A. Michalowsky, Peter A. Jones
openaire +4 more sources
Genome-wide negative feedback drives transgenerational DNA methylation dynamics in Arabidopsis. [PDF]
PLoS Genetics, 2015 Epigenetic variations of phenotypes, especially those associated with DNA methylation, are often inherited over multiple generations in plants. The active and inactive chromatin states are heritable and can be maintained or even be amplified by positive ...
Tasuku Ito +11 more
doaj +1 more source
The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection
Frontiers in Immunology, 2021 Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years.
Wanhai Qin +4 more
doaj +1 more source
Bioinform., 2014 MOTIVATION The recently released Infinium HumanMethylation450 array (the '450k' array) provides a high-throughput assay to quantify DNA methylation (DNAm) at ∼450 000 loci across a range of genomic features.
Martin J. Aryee +6 more
semanticscholar +1 more source
Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes
Frontiers in Physiology, 2014 DNA methylation patterns and functions are variable across invertebrate taxa. In order to provide a better understanding of DNA methylation in the Pacific oyster (Crassostrea gigas), we characterized the genome-wide DNA methylation profile in male gamete
Claire E. Olson, Steven B. Roberts
doaj +1 more source