Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. [PDF]
PLoS ONE, 2010 Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer.
Stella Tommasi +5 more
doaj +1 more source
Methylated DNA Immunoprecipitation [PDF]
Journal of Visualized Experiments, 2009 The identification of DNA methylation patterns is a common procedure in the study of epigenetics, as methylation is known to have significant effects on gene expression, and is involved with normal development as well as disease. Thus, the ability to discriminate between methylated DNA and non-methylated DNA is essential for generating methylation ...
Carolyn J. Brown +10 more
openaire +3 more sources
Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta. [PDF]
PLoS ONE, 2014 A small number of recent reports have suggested that altered placental DNA methylation may be associated with early onset preeclampsia. It is important that further studies be undertaken to confirm and develop these findings.
Tianjiao Chu +6 more
doaj +1 more source
DNA methylation age of human tissues and cell types
Genome Biology, 2013 It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure.
S. Horvath
semanticscholar +1 more source
Genome-wide negative feedback drives transgenerational DNA methylation dynamics in Arabidopsis. [PDF]
PLoS Genetics, 2015 Epigenetic variations of phenotypes, especially those associated with DNA methylation, are often inherited over multiple generations in plants. The active and inactive chromatin states are heritable and can be maintained or even be amplified by positive ...
Tasuku Ito +11 more
doaj +1 more source
Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis. [PDF]
, 2019 The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation to control gene expression.
Chory, Joanne +9 more
core +2 more sources
Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes
Frontiers in Physiology, 2014 DNA methylation patterns and functions are variable across invertebrate taxa. In order to provide a better understanding of DNA methylation in the Pacific oyster (Crassostrea gigas), we characterized the genome-wide DNA methylation profile in male gamete
Claire E. Olson, Steven B. Roberts
doaj +1 more source
The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection
Frontiers in Immunology, 2021 Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years.
Wanhai Qin +4 more
doaj +1 more source
The DNA methylation inhibitor 5-aza-2’-deoxycytidine retards cell growth and alters gene expression in canine mammary gland tumor cells [PDF]
, 2017 Disruption of gene expression by DNA methylation changes is widely involved in tumorigenesis. Here,to investigate DNA methylation changes in canine, we treated a canine mammary gland tumor cell line with a DNA methylation inhibitor, 5-aza-2 ...
Ito, Tsuyoshi, Kaneda, Masahiro
core +1 more source
DNA methylation-based classification of central nervous system tumours
Nature, 2018 Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper +142 more
semanticscholar +1 more source