Results 21 to 30 of about 2,768,548 (336)

Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes

Frontiers in Physiology, 2014
DNA methylation patterns and functions are variable across invertebrate taxa. In order to provide a better understanding of DNA methylation in the Pacific oyster (Crassostrea gigas), we characterized the genome-wide DNA methylation profile in male gamete
Claire E. Olson, Steven B. Roberts
doaj   +1 more source

Predictors and consequences of global DNA methylation in cord blood and at three years. [PDF]

PLoS ONE, 2013
DNA methylation changes have been implicated in many common chronic diseases leading to the hypothesis that environmental and age-related DNA methylation changes within individuals are involved in disease etiology.
Julie B Herbstman, Shuang Wang, Frederica P Perera, Sally A Lederman, Julia Vishnevetsky, Andrew G Rundle, Lori A Hoepner, Lirong Qu, Deliang Tang   +8 more
doaj   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

DNA methylation-based classification of central nervous system tumours

Nature, 2018
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper, David T. W. Jones, M. Sill, V. Hovestadt, D. Schrimpf, D. Sturm, C. Koelsche, F. Sahm, L. Chavez, D. Reuss, A. Kratz, A. Wefers, Kristin Huang, K. Pajtler, L. Schweizer, D. Stichel, A. Olar, Nils W. Engel, K. Lindenberg, P. Harter, Anne K. Braczynski, K. Plate, H. Dohmen, B. Garvalov, R. Coras, A. Hölsken, E. Hewer, M. Bewerunge-Hudler, M. Schick, R. Fischer, R. Beschorner, J. Schittenhelm, O. Staszewski, K. Wani, P. Varlet, M. Pages, P. Temming, D. Lohmann, F. Selt, H. Witt, T. Milde, O. Witt, E. Aronica, F. Giangaspero, E. Rushing, W. Scheurlen, C. Geisenberger, F. Rodriguez, A. Becker, M. Preusser, C. Haberler, R. Bjerkvig, J. Cryan, M. Farrell, M. Deckert, J. Hench, S. Frank, J. Serrano, Kasthuri Kannan, A. Tsirigos, W. Brück, S. Hofer, S. Brehmer, M. Seiz-Rosenhagen, D. Hänggi, V. Hans, S. Rozsnoki, J. Hansford, P. Kohlhof, B. Kristensen, M. Lechner, Beatriz Lopes, C. Mawrin, R. Ketter, A. Kulozik, Z. Khatib, F. Heppner, A. Koch, A. Jouvet, C. Keohane, H. Mühleisen, W. Müller, U. Pohl, M. Prinz, A. Benner, M. Zapatka, N. Gottardo, P. Driever, C. Kramm, H. Müller, S. Rutkowski, K. Hoff, M. Frühwald, A. Gnekow, G. Fleischhack, S. Tippelt, G. Calaminus, C. Monoranu, A. Perry, Chris Jones, T. Jacques, B. Radlwimmer, M. Gessi, T. Pietsch, J. Schramm, G. Schackert, M. Westphal, G. Reifenberger, P. Wesseling, M. Weller, V. Collins, I. Blümcke, M. Bendszus, J. Debus, A. Huang, N. Jabado, P. Northcott, W. Paulus, A. Gajjar, G. Robinson, Michael D. Taylor, Z. Jaunmuktane, M. Ryzhova, M. Platten, A. Unterberg, W. Wick, M. Karajannis, M. Mittelbronn, T. Acker, C. Hartmann, K. Aldape, U. Schüller, R. Buslei, P. Lichter, M. Kool, C. Herold‐Mende, D. Ellison, M. Hasselblatt, M. Snuderl, S. Brandner, A. Korshunov, A. Deimling, S. Pfister   +142 more
semanticscholar   +1 more source

Dynamics of DNA Methylation and Its Functions in Plant Growth and Development

Frontiers in Plant Science, 2021
Epigenetic modifications in DNA bases and histone proteins play important roles in the regulation of gene expression and genome stability. Chemical modification of DNA base (e.g., addition of a methyl group at the fifth carbon of cytosine residue ...
Suresh Kumar, T. Mohapatra
semanticscholar   +1 more source

A Feature Selection Algorithm to Compute Gene Centric Methylation from Probe Level Methylation Data [PDF]

, 2016
DNA methylation is an important epigenetic event that effects gene expression during development and various diseases such as cancer. Understanding the mechanism of action of DNA methylation is important for downstream analysis.
Baur, Brittany, Bozdag, Serdar
core   +13 more sources

DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma

Frontiers in Cell and Developmental Biology, 2022
Growing evidence links DNA methylation to tumor immunity. The impact of DNA methylation (5 mC) on the microenvironment surrounding tumors and immunotherapy remains to be clarified. Through clustering gene expression of 20 DNA methylation regulators, this
Xinyu Yu, Yijun Che, Weiyang Li, Peng Zhang, Yunhu Yu, Yunhu Yu, Jialin Chen, Ting Gong, Fang Cao   +8 more
doaj   +1 more source

DNA methylation GrimAge strongly predicts lifespan and healthspan

Aging, 2019
It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan.
A. Lu, Austin Quach, James G. Wilson, A. Reiner, A. Aviv, K. Raj, L. Hou, A. Baccarelli, Yun Li, J. Stewart, E. Whitsel, T. Assimes, L. Ferrucci, S. Horvath   +13 more
semanticscholar   +1 more source

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Cell Reports, 2019
Summary: Altered DNA methylation plays an important role in the onset and progression of kidney disease. However, little is known about how the changes arise in disease states.
Akihito Hishikawa, Kaori Hayashi, Takaya Abe, Mari Kaneko, Hideki Yokoi, Tatsuhiko Azegami, Mari Nakamura, Norifumi Yoshimoto, Takeshi Kanda, Yusuke Sakamaki, Hiroshi Itoh   +10 more
doaj   +1 more source

DNA methylation patterns and epigenetic memory.

Genes & Development, 2002
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional ...
A. Bird
semanticscholar   +1 more source