Results 21 to 30 of about 2,729,754 (384)

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

Frontiers in Immunology, 2021
Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years.
Wanhai Qin, Brendon P. Scicluna, Brendon P. Scicluna, Tom van der Poll, Tom van der Poll   +4 more
doaj   +1 more source

DNA methylation age of human tissues and cell types

Genome Biology, 2013
It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure.
S. Horvath
semanticscholar   +1 more source

Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis. [PDF]

, 2019
The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation to control gene expression.
Chory, Joanne, Feng, Suhua, Gallego-Bartolomé, Javier, Gardiner, Jason, Ghoshal, Basudev, Jacobsen, Steven E, Kuo, Peggy Hsuanyu, Liu, Wanlu, Park, Soo Young, Zhao, Jenny Miao-Chi   +9 more
core   +2 more sources

DNA methylation and regulation of gene expression: Guardian of our health

The Nucleus, 2021
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is the methylation of DNA at the C-5 position of the cytosine ring.
Gaurab Aditya Dhar, Shagnik Saha, Parama Mitra, Ronita Nag Chaudhuri   +3 more
semanticscholar   +1 more source

Methylated DNA Immunoprecipitation [PDF]

Journal of Visualized Experiments, 2009
The identification of DNA methylation patterns is a common procedure in the study of epigenetics, as methylation is known to have significant effects on gene expression, and is involved with normal development as well as disease. Thus, the ability to discriminate between methylated DNA and non-methylated DNA is essential for generating methylation ...
Carolyn J. Brown, Wan L. Lam, Wan L. Lam, Cameron Heryet, Ian M. Wilson, Ian M. Wilson, Emily A. Vucic, Emily A. Vucic, Kelsie L. Thu, Jennifer Y. Kennett, Jennifer Y. Kennett   +10 more
openaire   +3 more sources

SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]

, 2015
Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei, Gao, Lei, Kim, Yun Ju, Li, Shaofang, Li, Shengben, Liu, Lin, Zhao, Yuanyuan   +6 more
core   +2 more sources

DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma

Frontiers in Cell and Developmental Biology, 2022
Growing evidence links DNA methylation to tumor immunity. The impact of DNA methylation (5 mC) on the microenvironment surrounding tumors and immunotherapy remains to be clarified. Through clustering gene expression of 20 DNA methylation regulators, this
Xinyu Yu, Yijun Che, Weiyang Li, Peng Zhang, Yunhu Yu, Yunhu Yu, Jialin Chen, Ting Gong, Fang Cao   +8 more
doaj   +1 more source

DNA methylation in fibrosis [PDF]

European Journal of Cell Biology, 2016
Fibrosis is characterised by an exuberant wound healing response and the major cell type responsible is the myofibroblast. The myofibroblast is typified by excessive ECM production and contractile activity and is demarcated by alpha-smooth muscle actin expression. What has recently come to light is that the activation of the fibroblast to myofibroblast
Steven O'Reilly, Christopher G. Dowson
openaire   +3 more sources

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes

Frontiers in Physiology, 2014
DNA methylation patterns and functions are variable across invertebrate taxa. In order to provide a better understanding of DNA methylation in the Pacific oyster (Crassostrea gigas), we characterized the genome-wide DNA methylation profile in male gamete
Claire E. Olson, Steven B. Roberts
doaj   +1 more source