Results 41 to 50 of about 2,729,754 (384)
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]
, 2010 Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A +26 more
core +6 more sources
A Feature Selection Algorithm to Compute Gene Centric Methylation from Probe Level Methylation Data [PDF]
, 2016 DNA methylation is an important epigenetic event that effects gene expression during development and various diseases such as cancer. Understanding the mechanism of action of DNA methylation is important for downstream analysis.
Baur, Brittany, Bozdag, Serdar
core +13 more sources
Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies
Neuropsychopharmacology Reports, 2019 Introduction Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene‐environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in cohort studies ...
Yui Murata +10 more
doaj +1 more source
Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes
Cell Reports, 2019 Summary: Altered DNA methylation plays an important role in the onset and progression of kidney disease. However, little is known about how the changes arise in disease states.
Akihito Hishikawa +10 more
doaj +1 more source
BioTechniques, 2015 Variations in DNA methylation have been implicated in a number of disorders. Changes in global DNA methylation levels have long been associated with various types of cancer.
Elif Aysimi Duman +3 more
doaj +1 more source
Swiss Medical Weekly, 2013 DNA methylation, the addition of a methyl group to cytosines and adenosines, regulates gene expression on a level that is usually referred to as epigenetic, that is, stably maintained during cell divisions. In humans, aberrant DNA methylation is associated with several malignancies, including cancer and so-called imprinting disorders, making it an ...
T von Känel, Andreas Huber
openaire +4 more sources
DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. [PDF]
, 2019 Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase
Fischer, Robert L +6 more
core +2 more sources
Frontiers in Physiology, 2014 DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level,
Guillaume eRiviere, Guillaume eRiviere
doaj +1 more source
Genome-wide negative feedback drives transgenerational DNA methylation dynamics in Arabidopsis. [PDF]
PLoS Genetics, 2015 Epigenetic variations of phenotypes, especially those associated with DNA methylation, are often inherited over multiple generations in plants. The active and inactive chromatin states are heritable and can be maintained or even be amplified by positive ...
Tasuku Ito +11 more
doaj +1 more source
DNA methylation patterns and epigenetic memory.
Genes & Development, 2002 The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional ...
A. Bird
semanticscholar +1 more source