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Role of genetic and environmental factors in DNA methylation of lipid metabolism
Genes and Diseases, 2018 A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate ...
Zhen He +4 more
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Classification of large DNA methylation datasets for identifying cancer drivers [PDF]
F. Celli, F. Cumbo, E. Weitschek: Classification of Large DNA
Methylation Datasets for Identifying Cancer Drivers. Big Data Research,
10.1016/j.bdr.2018.02.005, 2018, 2018 DNA methylation is a well-studied genetic modification crucial to regulate the functioning of the genome. Its alterations play an important role in tumorigenesis and tumor-suppression. Thus, studying DNA methylation data may help biomarker discovery in cancer.
arxiv +1 more source
, 2023 DNA methylation, one of the most studied epigenetic modifications, refers to the addition of a methyl group to the fifth carbon of cytosine (C) catalyzed by DNA methyltransferases(Dnmts), forming 5-methylcytosine (5mC). DNA methylation predominantly occurs inCpGs but is also found in non-CpG contexts.
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Parenting stress and DNA methylation among African Americans in the InterGEN Study
Journal of Clinical and Translational Science, 2017 IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described.
Michelle L. Wright +6 more
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PLoS Genetics, 2020 Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa that ...
Fredrika Åsenius +9 more
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Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression [PDF]
Annals of Applied Statistics 2015, Vol. 9, No. 4, 2052-2072, 2016 This paper explores the transgenerational DNA methylation pattern (DNA methylation transmitted from one generation to the next) via a clustering approach. Beta regression is employed to model the transmission pattern from parents to their offsprings at the population level.
arxiv +1 more source
Swiss Medical Weekly, 2013 DNA methylation, the addition of a methyl group to cytosines and adenosines, regulates gene expression on a level that is usually referred to as epigenetic, that is, stably maintained during cell divisions. In humans, aberrant DNA methylation is associated with several malignancies, including cancer and so-called imprinting disorders, making it an ...
T von Känel, Andreas Huber
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DNA Methylation and Atherosclerosis [PDF]
The Journal of Nutrition, 2002 DNA methylation is a major epigenetic modification of the genome that has the potential to silence gene expression. Recently, the role of epigenetic alteration as a distinct and crucial mechanism to regulate genes governing cell proliferation in atherosclerosis has emerged.
Woohyun Yoon +2 more
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Decreased DNA methylation of a CpG site in the HBAP1 gene in plasma DNA from pregnant women. [PDF]
PLoS ONE, 2018 OBJECTIVE:The objective of this study is to identify potential CpG site(s) or DNA methylation pattern(s) in the pseudo α-globin 1 gene (HBAP1 gene), the gene which locates in α-thalassemia-1 deletion mutation, to differentiate plasma DNA between pregnant
Tanapat Pangeson +3 more
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Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns
Frontiers in Microbiology, 2021 DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by transferring a methyl group to DNA. The genetic variation in DNMTs results in differential DNA methylation patterns associated with various biological processes.
Yu-Shin Nai +6 more
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