Results 41 to 50 of about 2,686,549 (398)

DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma

Frontiers in Cell and Developmental Biology, 2022
Growing evidence links DNA methylation to tumor immunity. The impact of DNA methylation (5 mC) on the microenvironment surrounding tumors and immunotherapy remains to be clarified. Through clustering gene expression of 20 DNA methylation regulators, this
Xinyu Yu, Yijun Che, Weiyang Li, Peng Zhang, Yunhu Yu, Yunhu Yu, Jialin Chen, Ting Gong, Fang Cao   +8 more
doaj   +1 more source

Methylation of the imprinted GNAS1 gene in cell-free plasma DNA : equal steady-state quantities of methylated and unmethylated DNA in plasma [PDF]

, 2008
Background Genomic DNA sequences in cell-free plasma are biomarkers of cancer prognosis, where characteristic changes in methylation of tumour suppressor or oncogene DNA regions are indicative of changes in gene activity.
Alberry, Anker, Bauer, Bianchi, Birch, Chim, Deligezer, Eggermann, Francesco Crea, Grunau, Honda, Jahr, Januchowski, Kamaljit Chatha, Kawakami, Li, Lo, Lui, Robert W. Old, Selina Elsenheimer, Sorenson, Stroun, Stroun, Tsang, Van der Schoot, Vasioukhin, William M. Puszyk   +26 more
core   +1 more source

DNA methylation and cancer [PDF]

Oncogene, 2002
There is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization that the 'histone code', which involves the post-translational modification of histones and which has important ramifications for chromatin structure, may be ...
openaire   +5 more sources

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies

Neuropsychopharmacology Reports, 2019
Introduction Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene‐environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in cohort studies ...
Yui Murata, Ayaka Fujii, Sho Kanata, Shinya Fujikawa, Tempei Ikegame, Yutaka Nakachi, Zhilei Zhao, Seiichiro Jinde, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto   +10 more
doaj   +1 more source

Minimal evidence for consistent changes in maize DNA methylation patterns following environmental stress.

Frontiers in Plant Science, 2015
DNA methylation is a chromatin modification that is sometimes associated with epigenetic regulation of gene expression. As DNA methylation can be reversible at some loci, it is possible that methylation patterns may change within an organism that is ...
Steven R Eichten, Nathan M Springer
doaj   +1 more source

HPA axis related genes and response to psychological therapies: genetics and epigenetics [PDF]

, 2015
Background Hypothalamic–pituitary–adrenal (HPA) axis functioning has been implicated in the development of stress-related psychiatric diagnoses and response to adverse life experiences. This study aimed to investigate the association between genetic
Arendt, Kristian, Blatter-Meunier, Judith, Breen, Gerome, Coleman, Jonathan R I, Cooper, Peter, Creswell, Cathy, Eley, Thalia C, Fjermestad, Krister, Havik, Odd E, Herren, Chantal, Hogendoorn, Sanne M, Hudson, Jennifer L, Keers, Robert, Krause, Karen, Lester, Kathryn J, Lyneham, Heidi J, Morris, Talia, Nauta, Maaike, Rapee, Ronald M, Rey, Yasmin, Roberts, Susanna, Schneider, Silvia, Schneider, Sophie C, Silverman, Wendy K, Thastum, Mikael, Thirlwall, Kerstin, Waite, Polly, Wong, Chloe C Y   +27 more
core   +1 more source

DNA methylation patterns and epigenetic memory.

Genes & Development, 2002
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional ...
A. Bird
semanticscholar   +1 more source

Role of genetic and environmental factors in DNA methylation of lipid metabolism

Genes and Diseases, 2018
A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate ...
Zhen He, Rong Zhang, Feng Jiang, Wenjing Hou, Cheng Hu   +4 more
doaj   +1 more source

Assessing the preservation of cytosine methylation in ancient DNA from five prehistoric Native American populations [PDF]

, 2015
textCytosine methylation of CpG dinucleotides is an important epigenetic mark that regulates gene expression in humans. While methylation patterns in extant populations have been widely studied, few studies have attempted to analyze methylation in ...
Smith, Ricky Wayne Aldon
core   +1 more source