Results 21 to 30 of about 151,241 (263)

A DNA methylation age predictor for zebrafish. [PDF]

Aging (Albany NY), 2020
Changes in DNA methylation at specific CpG sites have been used to build predictive models to estimate animal age, predominantly in mammals. Little testing for this effect has been conducted in other vertebrate groups, such as bony fish, the largest vertebrate class.
Mayne B, Korbie D, Kenchington L, Ezzy B, Berry O, Jarman S.   +5 more
europepmc   +3 more sources

Research Progress on the Detection Method of DNA Methylation and Its Application in Forensic Science [PDF]

Fayixue Zazhi, 2017
As an important part of epigenetic marker, DNA methylation involves in the gene regulation and attracts a wide spread attention in biological auxology, geratology and oncology fields.
NIE YAN-CHAI, YU LI-JUAN, GUAN HUA, ET AL.
doaj   +1 more source

DNA methylation and healthy human aging [PDF]

Aging Cell, 2015
SummaryThe process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic patterns also change over the lifespan, suggesting that epigenetic changes may constitute an important component of the aging process.
Jones, Meaghan J., Goodman, Sarah J., Kobor, Michael S.   +2 more
openaire   +2 more sources

DNA methylation age and physical and cognitive ageing

The Journals of Gerontology: Series A, 2019
Abstract Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be predictive of all-cause mortality but it is unclear what functional aspect/s of ageing it captures. We examine associations between four measures of AgeAccel in adults aged 45-87 years and physical and ...
Maddock, Jane, Castillo-Fernandez, Juan, Wong, Andrew, Cooper, Rachel, Richards, Marcus, Ong, Ken K, Ploubidis, George B, Goodman, Alissa, Kuh, Diana, Bell, Jordana, Hardy, Rebecca   +10 more
openaire   +6 more sources

DNA methylation aging clocks: challenges and recommendations [PDF]

Genome Biology, 2019
AbstractEpigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating ...
Bell, C.G., Lowe, R., Adams, P.D., Baccarelli, A.A., Beck, S., Bell, J.T., Christensen, B.C., Gladyshev, V.N., Heijmans, B.T., Horvath, S., Ideker, T., Issa, J.P.J., Kelsey, K.T., Marioni, R.E., Reik, W., Relton, C.L., Schalkwyk, L.C., Teschendorff, A.E., Wagner, W., Zhang, K., Rakyan, V.K.   +20 more
openaire   +10 more sources

High plasma organochlorine pesticide levels are related to increased biological age as calculated by DNA methylation analysis

Environment International, 2018
Background: Organochlorine pesticides (OCPs) have been shown in the experimental setting to alter DNA methylation. Since DNA methylation changes during the life-span, formulas have been presented to calculate “DNA methylation age” as a measure of ...
P. Monica Lind, Samira Salihovic, Lars Lind   +2 more
doaj   +1 more source

Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients. [PDF]

PLoS ONE, 2016
DNA methylation is believed to regulate gene expression during adulthood in response to the constant changes in environment. The methylome is therefore proposed to be a biomarker of health through age.
Albert Nguyen, Maya Mamarbachi, Valérie Turcot, Samuel Lessard, Carol Yu, Xiaoyan Luo, Julie Lalongé, Doug Hayami, Mathieu Gayda, Martin Juneau, Nathalie Thorin-Trescases, Guillaume Lettre, Anil Nigam, Eric Thorin   +13 more
doaj   +1 more source

Shift Work, DNA methylation and Epigenetic Age [PDF]

ISEE Conference Abstracts, 2019
Abstract Background Shift work has been associated with increased risk of age-related morbidity and mortality. Biological age, estimated using DNA methylation (DNAm), may quantify the biological consequences of shift work on the risk of age-related disease.
Alexandra J, White, Jacob K, Kresovich, Zongli, Xu, Dale P, Sandler, Jack A, Taylor   +4 more
openaire   +2 more sources

Evaluation of age-associated DNA methylation markers in colorectal cancer of Thai population

Forensic Science International: Reports, 2022
Age prediction using biomarkers has been extensively studied which can be helpful in forensic and health sciences. DNA methylation has been demonstrated to be the most promising molecular biomarkers for age prediction in forensic sciences, and many ...
Tanaporn Lucknuch, Pairoa Praihirunkit
doaj   +1 more source

DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function [PDF]

International Journal of Molecular Sciences, 2018
Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive abilities, is a major risk factor for age-associated neurodegenerative disorders such as Alzheimer’s disease. Emerging evidence suggests that epigenetics, an inheritable but reversible biochemical process, plays a crucial role in the pathogenesis of age-related ...
Cui, D., Xu, X.
openaire   +3 more sources