Results 31 to 40 of about 267,722 (305)

DNA methylation aging clocks: challenges and recommendations [PDF]

Genome Biology, 2019
AbstractEpigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating ...
Bell, C.G., Lowe, R., Adams, P.D., Baccarelli, A.A., Beck, S., Bell, J.T., Christensen, B.C., Gladyshev, V.N., Heijmans, B.T., Horvath, S., Ideker, T., Issa, J.P.J., Kelsey, K.T., Marioni, R.E., Reik, W., Relton, C.L., Schalkwyk, L.C., Teschendorff, A.E., Wagner, W., Zhang, K., Rakyan, V.K.   +20 more
openaire   +10 more sources

High plasma organochlorine pesticide levels are related to increased biological age as calculated by DNA methylation analysis

Environment International, 2018
Background: Organochlorine pesticides (OCPs) have been shown in the experimental setting to alter DNA methylation. Since DNA methylation changes during the life-span, formulas have been presented to calculate “DNA methylation age” as a measure of ...
P. Monica Lind, Samira Salihovic, Lars Lind   +2 more
doaj   +1 more source

Accelerated placental aging in early onset preeclampsia pregnancies identified by DNA methylation. [PDF]

, 2017
Aim: To determine whether dynamic DNA methylation changes in the human placenta can be used to predict gestational age. Materials & methods: Publicly available placental DNA methylation data from 12 studies, together with our own dataset, using Illumina ...
Bianco-Miotto, T., Breen, J., Leemaqz, S., Mayne, B., Roberts, C., Smith, A.   +5 more
core   +1 more source

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). [PDF]

, 2018
BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and ...
Agha, Golareh, Baccarelli, Andrea A, Cardenas, Andres, Coull, Brent A, de Kluizenaar, Yvonne, DeMeo, Dawn L, den Dekker, Martijn, Duijts, Liesbeth, Felix, Janine F, Gibson, Heike, Gilman, Matthew W, Gold, Diane R, Harris, Maria H, Hivert, Marie-France, Jaddoe, Vincent W, Litonjua, Augusto A, Oken, Emily, Peng, Cheng, Rifas-Shiman, Sheryl L, Sagiv, Sharon K, Schwartz, Joel   +20 more
core   +1 more source

Shift Work, DNA methylation and Epigenetic Age [PDF]

ISEE Conference Abstracts, 2019
Abstract Background Shift work has been associated with increased risk of age-related morbidity and mortality. Biological age, estimated using DNA methylation (DNAm), may quantify the biological consequences of shift work on the risk of age-related disease.
Alexandra J, White, Jacob K, Kresovich, Zongli, Xu, Dale P, Sandler, Jack A, Taylor   +4 more
openaire   +2 more sources

Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients. [PDF]

PLoS ONE, 2016
DNA methylation is believed to regulate gene expression during adulthood in response to the constant changes in environment. The methylome is therefore proposed to be a biomarker of health through age.
Albert Nguyen, Maya Mamarbachi, Valérie Turcot, Samuel Lessard, Carol Yu, Xiaoyan Luo, Julie Lalongé, Doug Hayami, Mathieu Gayda, Martin Juneau, Nathalie Thorin-Trescases, Guillaume Lettre, Anil Nigam, Eric Thorin   +13 more
doaj   +1 more source

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. [PDF]

, 2007
Epigenetic variation may significantly contribute to the risk of common disease. Currently, little is known about the extent and causes of epigenetic variation.
Abecasis, Barrett, Bastiaan T. Heijmans, Bjornsson, Bock, Boomsma, Castro, Cruz-Correa, Cui, Dennis Kremer, Dorret I. Boomsma, Ehrich, Elmar W. Tobi, Feltus, Fraga, Friso, Heijmans, Jacob, Jaenisch, Jiang, Jones, Martin, Morgan, O'Dell, P. Eline Slagboom, Petronis, Petry, Rampersaud, Robertson, Sandovici, Sandovici, Snieder, Van Laere, Vu, Waterland, Waterland, Zaina   +36 more
core   +2 more sources

Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer [PDF]

, 2014
Background: Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer.
Alizadeh-Navaei, R., Azadeh, H., Farazmandfar, T., Samaei, N.M., Yazdani, Y.   +4 more
core   +1 more source

DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function [PDF]

International Journal of Molecular Sciences, 2018
Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive abilities, is a major risk factor for age-associated neurodegenerative disorders such as Alzheimer’s disease. Emerging evidence suggests that epigenetics, an inheritable but reversible biochemical process, plays a crucial role in the pathogenesis of age-related ...
Cui, D., Xu, X.
openaire   +3 more sources

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie, Cox, Simon R, Deary, Ian J, Gibson, Jude, Harris, Sarah E, Horvath, Steve, Marioni, Riccardo E, McRae, Allan F, Muniz-Terrera, Graciela, Murphy, Lee, Pattie, Alison, Redmond, Paul, Ritchie, Stuart J, Shah, Sonia, Starr, John M, Taylor, Adele, Visscher, Peter M, Wray, Naomi R   +17 more
core   +1 more source