Results 21 to 30 of about 267,722 (305)

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

A DNA methylation age predictor for zebrafish. [PDF]

Aging (Albany NY), 2020
Changes in DNA methylation at specific CpG sites have been used to build predictive models to estimate animal age, predominantly in mammals. Little testing for this effect has been conducted in other vertebrate groups, such as bony fish, the largest vertebrate class.
Mayne B, Korbie D, Kenchington L, Ezzy B, Berry O, Jarman S.   +5 more
europepmc   +3 more sources

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

Research Progress on the Detection Method of DNA Methylation and Its Application in Forensic Science [PDF]

Fayixue Zazhi, 2017
As an important part of epigenetic marker, DNA methylation involves in the gene regulation and attracts a wide spread attention in biological auxology, geratology and oncology fields.
NIE YAN-CHAI, YU LI-JUAN, GUAN HUA, ET AL.
doaj   +1 more source

DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with Ulcerative Colitis (UC) [PDF]

, 2010
Introduction: Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures.
Arasaradnam, Ramesh P., Bradburn, Mike, Kelly, S. B., Khoo, K. T. J., Mathers, John C.   +4 more
core   +1 more source

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARKAGE Study [PDF]

, 2016
Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in ...
Bacalini, Maria Giulia, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Ciccarone, Fabio, Dollé, Martijn E.T., Franceschi, Claudio, Gonos, Efstathios S, Grune, Tilman, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno-Villanueva, María, Reale, Anna, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Valentini, Elisabetta, Zampieri, Michele   +24 more
core   +2 more sources

Correlation between DNA methylation and chronological age of Moso bamboo (Phyllostachys heterocycla var. pubescens) [PDF]

, 2014
Background Chronological age is the primary consideration when studying the physiological development, aging, and flowering of bamboo. However, it’s difficult to determine bamboo’s chronological age if the time of germination is unknown.
Guang-Ping Guo, Hui-Min Sun, Jin-Jun Yue, Jin-Ling Yuan, Xiao-Ping Gu   +4 more
core   +1 more source

DNA methylation and healthy human aging [PDF]

Aging Cell, 2015
SummaryThe process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic patterns also change over the lifespan, suggesting that epigenetic changes may constitute an important component of the aging process.
Jones, Meaghan J., Goodman, Sarah J., Kobor, Michael S.   +2 more
openaire   +2 more sources

DNA Methylation in Acacia mangium ln vitro and Ex-vitro buds, in relation to their within-shoot position, age and leaf morphology of the shoots [PDF]

, 2009
DNA methylation was analyzed in Acacia mangium Willd. buds collected from in vitro and field growing shoots from the same clone and its juvenile offspring.
Baurens, Franc-Christophe, Doulbeau, Sylvie, Goh, Doreen Kim Soh, Monteuuis, Olivier, Quimado, M., Verdeil, Jean-Luc   +5 more
core   +1 more source

DNA methylation age and physical and cognitive ageing

The Journals of Gerontology: Series A, 2019
Abstract Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be predictive of all-cause mortality but it is unclear what functional aspect/s of ageing it captures. We examine associations between four measures of AgeAccel in adults aged 45-87 years and physical and ...
Maddock, Jane, Castillo-Fernandez, Juan, Wong, Andrew, Cooper, Rachel, Richards, Marcus, Ong, Ken K, Ploubidis, George B, Goodman, Alissa, Kuh, Diana, Bell, Jordana, Hardy, Rebecca   +10 more
openaire   +6 more sources