Epigenetics, 2023 The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are not well studied
Allison Reiner +8 more
doaj +1 more source
Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]
, 2017 ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F +16 more
core +1 more source
Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes
Frontiers in Genetics, 2019 The biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was initially considered a promising biomarker for the prediction of ...
Fu-Hui Xiao +15 more
doaj +1 more source
Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy [PDF]
, 2013 BACKGROUND: Preterm birth confers a high risk of adverse long term health outcomes for survivors, yet the underlying molecular mechanisms are unclear.
Alicia Oshlack +9 more
core +3 more sources
Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study [PDF]
, 2016 Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood.
Bacalini, MARIA GIULIA +26 more
core +2 more sources
Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]
, 2020 Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
core +1 more source
Aging, DNA methylation and cancer
Critical Reviews in Oncology/Hematology, 1999 2. DNA methylation patterns in normal cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 2.1. Normal DNA methylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 2.2. CpG islands . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire +2 more sources
Reconfiguration of DNA methylation in aging
Mechanisms of Ageing and Development, 2015 A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known
ZAMPIERI, Michele +5 more
openaire +4 more sources
Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa. [PDF]
PLoS ONE, 2016 DNA methylation plays important roles in the production and functioning of spermatozoa. Recent studies have suggested that DNA methylation patterns in spermatozoa can change with age, but the regions susceptible to age-related methylation changes remain ...
Norio Kobayashi +7 more
doaj +1 more source
In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]
, 2019 BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker +47 more
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